Unusual MRI findings in lymphocytic hypophysitis with central diabetes insipidus

1999 ◽  
Vol 41 (12) ◽  
pp. 899-900 ◽  
Author(s):  
A. Tamiya ◽  
N. Saeki ◽  
M. Kubota ◽  
T. Oheda ◽  
A. Yamaura
2000 ◽  
Vol 142 (4) ◽  
pp. 365-372 ◽  
Author(s):  
C Bullmann ◽  
M Faust ◽  
A Hoffmann ◽  
C Heppner ◽  
F Jockenhovel ◽  
...  

OBJECTIVES: We retrospectively reviewed 5 patients with neurosarcoidosis, who all presented with central diabetes insipidus and hypogonadism. DESIGN: This was a single-centre, retrospective analysis of 5 cases with a minimum follow-up of 2 years. METHODS: Case analysis included clinical, biochemical, and endocrinological evaluation and frequent CT/MRI scans of involved organs as primary evaluation and in response to immunosuppressive therapy. RESULT: Neurosarcoidosis was diagnosed in all patients. Two patients had no proven extracerebral manifestation and had a stable disease over 3 and 5 years. One patient showed deterioration with corticosteroids alone but partial remission after additional cyclophosphamide. Pituitary dysfunction remained unchanged in all patients, despite total clinical and radiological remission in two patients. However, one of these patients died of acute granulomatous meningoencephalitis after two years of follow-up. CONCLUSION: Although the presenting symptoms of neurosarcoidosis may vary, the occurrence of central diabetes insipidus associated with typical radiological features is suggestive of neurosarcoidosis. However, there is an increasing number of case reports on lymphocytic hypophysitis. Without the bioptic diagnosis, the differentiation between potentially lethal isolated neurosarcoidosis and lymphocytic hypophysitis is difficult. These cases demonstrate the difficulties in diagnosing neurosarcoidosis and reflect experiences with follow-up parameters.


2006 ◽  
Vol 22 (10) ◽  
pp. 1338-1343 ◽  
Author(s):  
Yoko Mikami-Terao ◽  
Masaharu Akiyama ◽  
Takaaki Yanagisawa ◽  
Junko Takahashi-Fujigasaki ◽  
Kentaro Yokoi ◽  
...  

2018 ◽  
Author(s):  
Ana Ferreira ◽  
Tiago Silva ◽  
Filipa Bastos ◽  
Isabel Manita ◽  
Maria Carlos Cordeiro ◽  
...  

2019 ◽  
Author(s):  
Najoua Lassoued ◽  
Salmane Wannes ◽  
Asma Wardani ◽  
Abir Omrane ◽  
Raoudha Boussofara ◽  
...  

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