Correlations between cervical spinal cord magnetic resonance diffusion tensor and diffusion kurtosis imaging metrics and motor performance in patients with chronic ischemic brain lesions of the corticospinal tract

2018 ◽  
Vol 61 (2) ◽  
pp. 175-182 ◽  
Author(s):  
Valentina Panara ◽  
R. Navarra ◽  
P. A. Mattei ◽  
E. Piccirilli ◽  
V. Bartoletti ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Motor Performance ◽  
Corticospinal Tract ◽  
Diffusion Tensor ◽  
Cervical Spinal Cord ◽  
Brain Lesions ◽  
Diffusion Kurtosis Imaging ◽  
Ischemic Brain ◽  
Diffusion Kurtosis ◽  
And Diffusion

scholarly journals Feasibility of Diffusion Kurtosis Imaging in Evaluating Cervical Spinal Cord Injury in Multiple Sclerosis

2022 ◽  
Author(s):  
BingYang Bian ◽  
ZhuoHang Liu ◽  
ZhiQing Shao ◽  
Pu Tian ◽  
YaQian Liang ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
White Matter ◽  
Therapeutic Effect ◽  
Gray Matter ◽  
Cervical Spinal Cord ◽  
Diffusion Kurtosis Imaging ◽  
Cord Injury ◽  
Before And After ◽  
Diffusion Kurtosis

Abstract Background：Quantitative evaluation of cervical spinal cord (CSC) injury in multiple sclerosis has always been a difficulty. The present study aimed to evaluate the lesion, normal-appearing gray matter (GM) and white matter (WM) damage, and therapeutic effect using diffusion kurtosis imaging (DKI) on CSC of patients with multiple sclerosis.Methods: A total of 48 patients with MS and 30 healthy adults, underwent routine MR scan and DKI of CSC. DKI-metrics were measured in the lesions and in the normal-appearing gray and white matter. MS patients were divided into those with and without T2-hyperintense lesions. Disability was assessed by the expanded disability status scale before and after therapy.Results：1) Significant differences were detected in MK, MD, and FA values between patients and healthy subjects (P < 0.05) and between patients with CSC T2-hyperintense and patients without T2-hyperintense (P < 0.05); 2) Compared to healthy, GM-MK and WM-FA were statistically reduced in patients without T2-hyperintense (P < 0.05). 3) Significant differences were observed in MK, MD, and FA between patients with T2-hyperintense after therapy (P < 0.05), as well as GM-MK and WM-FA in patients without T2-hyperintense (P < 0.05); 4) EDSS was correlated with MK values, as well as EDSS scores and MK values after therapy.Conclusions：1) DKI-metrics can detect and quantitatively evaluate the changes in cervical spinal cord micropathological structure; 2) MK values are sensitive metrics to detect the damage of gray matter; 3) MK values quantitatively evaluate the clinical disability progression and the therapeutic effect in MS patients.

Assessment of tissue heterogeneity using diffusion tensor and diffusion kurtosis imaging for grading gliomas

2016 ◽  
Vol 58 (12) ◽  
pp. 1217-1231 ◽  
Author(s):  
Rajikha Raja ◽  
Neelam Sinha ◽  
Jitender Saini ◽  
Anita Mahadevan ◽  
KVL Narasinga Rao ◽  
...  
Keyword(s):  
Diffusion Tensor ◽  
Diffusion Kurtosis Imaging ◽  
Tissue Heterogeneity ◽  
Diffusion Kurtosis ◽  
And Diffusion

scholarly journals Reproducibility of tract-specific magnetization transfer and diffusion tensor imaging in the cervical spinal cord at 3 tesla

2009 ◽  
pp. n/a-n/a ◽  
Author(s):  
Seth A. Smith ◽  
Craig K. Jones ◽  
Aliya Gifford ◽  
Visar Belegu ◽  
BettyAnn Chodkowski ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Cervical Spinal Cord ◽  
Magnetization Transfer ◽  
3 Tesla ◽  
Specific Magnetization ◽  
And Diffusion

scholarly journals Diffusion Kurtosis Imaging Fiber Tractography of Major White Matter Tracts in Neurosurgery

2021 ◽  
Vol 11 (3) ◽  
pp. 381
Author(s):  
Miriam H. A. Bopp ◽  
Julia Emde ◽  
Barbara Carl ◽  
Christopher Nimsky ◽  
Benjamin Saß
Keyword(s):  
White Matter ◽  
Corticospinal Tract ◽  
Diffusion Tensor ◽  
Clinical Applications ◽  
Diffusion Kurtosis Imaging ◽  
Fiber Tractography ◽  
White Matter Tracts ◽  
The Right ◽  
Diffusion Kurtosis ◽  
Diffusion Tensor Imaging Dti

Diffusion tensor imaging (DTI)-based fiber tractography is routinely used in clinical applications to visualize major white matter tracts, such as the corticospinal tract (CST), optic radiation (OR), and arcuate fascicle (AF). Nevertheless, DTI is limited due to its capability of resolving intra-voxel multi-fiber populations. Sophisticated models often require long acquisition times not applicable in clinical practice. Diffusion kurtosis imaging (DKI), as an extension of DTI, combines sophisticated modeling of the diffusion process with short acquisition times but has rarely been investigated in fiber tractography. In this study, DTI- and DKI-based fiber tractography of the CST, OR, and AF was investigated in healthy volunteers and glioma patients. For the CST, significantly larger tract volumes were seen in DKI-based fiber tractography. Similar results were obtained for the OR, except for the right OR in patients. In the case of the AF, results of both models were comparable with DTI-based fiber tractography showing even significantly larger tract volumes in patients. In the case of the CST and OR, DKI-based fiber tractography contributes to advanced visualization under clinical time constraints, whereas for the AF, other models should be considered.

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