Stimulation of the Growth of Femoral Trabecular Bone in Ovariectomized Rats by the Novel Parathyroid Hormone Fragment, hPTH-(1-31)NH 2 (Ostabolin)

1996 ◽  
Vol 58 (2) ◽  
pp. 81-87 ◽  
Author(s):  
J. F. Whitfield ◽  
P. Morley ◽  
G. E. Willick ◽  
V. Ross ◽  
J.-R. Barbier ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Trabecular Bone ◽  
Ovariectomized Rats ◽  
The Novel ◽  
Stimulation Of

Stimulation of the growth of femoral trabecular bone in ovariectomized rats by the novel parathyroid hormone fragment, hPTH-(1–31)NH2 (Ostabolin)

1996 ◽  
Vol 58 (2) ◽  
pp. 81-87 ◽  
Author(s):  
J. F. Whitfield ◽  
P. Morley ◽  
G. E. Willick ◽  
V. Ross ◽  
J. -R. Barbier ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Trabecular Bone ◽  
Ovariectomized Rats ◽  
The Novel ◽  
Stimulation Of

Stimulation of Femoral Trabecular Bone Growth in Ovariectomized Rats by Human Parathyroid Hormone (hPTH)-(1-30)NH 2

1999 ◽  
Vol 65 (2) ◽  
pp. 143-147 ◽  
Author(s):  
J. F. Whitfield ◽  
P. Morley ◽  
G. E. Willick ◽  
S. MacLean ◽  
V. Ross ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Trabecular Bone ◽  
Bone Growth ◽  
Ovariectomized Rats ◽  
Human Parathyroid Hormone ◽  
Stimulation Of

Transient reduction in trabecular bone formation after discontinuation of administration of oestradiol-17β to ovariectomized rats

1993 ◽  
Vol 137 (3) ◽  
pp. 497-503 ◽  
Author(s):  
J. H. Tobias ◽  
T. J. Chambers
Keyword(s):  
Bone Formation ◽  
Trabecular Bone ◽  
Marked Decrease ◽  
Inhibitory Effect ◽  
Ovariectomized Rats ◽  
Oestrogen Treatment ◽  
Early Effect ◽  
Oestrogen Deficiency ◽  
Old Rats ◽  
Stimulation Of

ABSTRACT While the osteopenia associated with oestrogen deficiency is thought to arise from a relative defect in bone formation with respect to resorption, oestrogen administration itself leads to a decrease, rather than an increase, in bone formation. This decrease in bone formation, which arises from oestrogen's inhibitory effect on bone turnover, presumably masks any underlying tendency of oestrogen treatment towards stimulation of bone formation. To investigate this further, we have examined the early effect of discontinuing the administration of oestradiol-17β (OE2; 40 μg/kg on bone formation indices in ovariectomized 13-week-old rats, before the turnover-induced increase in formation occurs. Histomorphometric indices were assessed at the proximal tibial metaphysis 0, 7, 10, 13 and 16 days following discontinuation of OE2 treatment. Measurements of body weight, uterine weight and longitudinal growth rate confirmed that there were rapid effects of OE2 deficiency on these parameters. We could detect no significant increase in bone resorption, as measured by osteoclast surface and number, until 16 days after ending treatment with OE2; this was coincidental with a reduction in bone volume. Shorter periods of OE2 deficiency were associated with a marked decrease in bone formation, as assessed by dynamic histomorphometric indices. This inhibition of bone formation was largely due to a reduction in double fluorochrome-labelled trabecular surfaces, which were decreased by approximately 70%. We conclude that ending OE2 administration in ovariectomized rats caused a striking decrease in trabecular bone formation, if such indices are assessed prior to the subsequent turnover-induced increase in formation. This suggests that oestrogen treatment in ovariectomized rats is associated with a stimulatory effect on bone formation, in addition to its recognized anti-resorptive action. Journal of Endocrinology (1993) 137, 497–503

Restoration of severely depleted femoral trabecular bone in ovariectomized rats by parathyroid hormone-(1?34)

1995 ◽  
Vol 56 (3) ◽  
pp. 227-231 ◽  
Author(s):  
J. F. Whitfield ◽  
P. Morley ◽  
V. Ross ◽  
R. J. Isaacs ◽  
R. H. Rixon
Keyword(s):  
Parathyroid Hormone ◽  
Trabecular Bone ◽  
Ovariectomized Rats

Bradykinin stimulates prostaglandin E2 formation in isolated human osteoblast-like cells

1990 ◽  
Vol 10 (1) ◽  
pp. 121-126 ◽  
Author(s):  
Östen Ljunggren ◽  
Jan Rosenquist ◽  
Maria Ransjö ◽  
Ulf H. Lerner
Keyword(s):  
Parathyroid Hormone ◽  
Cyclic Amp ◽  
Prostaglandin E2 ◽  
Trabecular Bone ◽  
Human Osteoblast ◽  
Human Osteoblasts ◽  
Human Trabecular Bone ◽  
Stimulation Of ◽  
In Cells

The effect of bradykinin on prostaglandin E2 formation in cells from human trabecular bone has been studied. The cells responded to parathyroid hormone with enhanced cyclic AMP formation and were growing as cuboidal-shaped, osteoblast-like cells. In these isolated human osteoblast-like cells, bradykinin (1 μmol/l) caused a rapid (5 min) stimulation of prostaglandin E2 formation. This finding indicates that human osteoblasts are equipped with receptors for bradykinin linked to an increase in prostaglandin formation.

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