Comparison of the ability of recombinant human parathyroid hormone, rhPTH-(1–84), and hPTH-(1–31)NH2 to stimulate femoral trabecular bone growth in ovariectomized rats

1997 ◽  
Vol 60 (1) ◽  
pp. 26-29 ◽  
Author(s):  
J. F. Whitfield ◽  
P. Morley ◽  
G. E. Willick ◽  
V. Ross ◽  
S. MacLean ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Trabecular Bone ◽  
Bone Growth ◽  
Ovariectomized Rats ◽  
Human Parathyroid Hormone

Stimulation of Femoral Trabecular Bone Growth in Ovariectomized Rats by Human Parathyroid Hormone (hPTH)-(1-30)NH 2

1999 ◽  
Vol 65 (2) ◽  
pp. 143-147 ◽  
Author(s):  
J. F. Whitfield ◽  
P. Morley ◽  
G. E. Willick ◽  
S. MacLean ◽  
V. Ross ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Trabecular Bone ◽  
Bone Growth ◽  
Ovariectomized Rats ◽  
Human Parathyroid Hormone ◽  
Stimulation Of

scholarly journals Prolonged low-dose infusion of human parathyroid hormone does not increase femoral cancellous bone volume in ovariectomized rats

1999 ◽  
pp. 70-74 ◽  
Author(s):  
P Morley ◽  
JF Whitfield ◽  
GE Willick ◽  
V Ross ◽  
S MacLean ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Cancellous Bone ◽  
Oral Delivery ◽  
Bone Growth ◽  
Bone Volume ◽  
Ovariectomized Rats ◽  
Low Doses ◽  
Human Parathyroid Hormone ◽  
Trabecular Thickness ◽  
Trabecular Number

OBJECTIVE: Daily injections of human parathyroid hormone (hPTH) increase bone volume in various animal species and in osteoporotic women. For hPTH to be widely accepted as an anabolic therapy for treating postmenopausal osteoporosis alternative delivery options need to be explored to replace the need for daily patient subcutaneous self-injection. Among these are inhalation, oral delivery and the use of programmable implanted minipumps to deliver the peptide. While infusion of high doses of PTH causes bone loss and hypercalcemia, no studies have assessed the effects of prolonged infusion of low doses of PTH on bone growth. DESIGN AND METHODS: [Leu(27)]-cyclo(Glu(22)-Lys(26))-hPTH-(1--31)NH(2) was delivered by Alzet minipumps to ovariectomized rats for 6 weeks after which histomorphometric indices (cancellous bone volume, trabecular thickness, mean trabecular number) of bone formation were measured in distal femurs. RESULTS: Infusing low doses (0.05 and 0.1 nmole/100g body weight/day) of the hPTH analog, [Leu(27)]-cyclo(Glu(22)-Lys(26))-hPTH-(1--31)NH(2), for 6 weeks does not prevent the ovariectomy-induced loss of rat femoral cancellous bone volume, trabecular thickness or trabecular number. CONCLUSION: These results support the absolute requirement of daily injections for the osteogenic action of hPTH on bone.

scholarly journals Restoring Effect of Human Parathyroid Hormone (1-34) on Trabecular Connectivity in Ovariectomized Rats.

2001 ◽  
Vol 194 (4) ◽  
pp. 213-221 ◽  
Author(s):  
Tsunehisa Tsuchida ◽  
Naohisa Miyakoshi ◽  
Takuya Kudo ◽  
Yasuki Tamura ◽  
Yuji Kasukawa ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Ovariectomized Rats ◽  
Human Parathyroid Hormone ◽  
Trabecular Connectivity
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