Effects of Risedronate Treatment on Bone Density and Vertebral Fracture in Patients on Corticosteroid Therapy

2000 ◽  
Vol 67 (4) ◽  
pp. 277-285 ◽  
Author(s):  
S. Wallach ◽  
S. Cohen ◽  
D. M. Reid ◽  
R. A. Hughes ◽  
D. J. Hosking ◽  
...  
Keyword(s):  
Vertebral Fracture ◽  
Bone Density ◽  
Corticosteroid Therapy

scholarly journals Effect of inhaled corticosteroid therapy on bone markers and bone density

Thorax ◽  
1999 ◽  
Vol 54 (9) ◽  
pp. 861-861
Author(s):  
M.-F. BEAUCHESNE; ◽  
J A HUGHES
Keyword(s):  
Bone Density ◽  
Corticosteroid Therapy ◽  
Bone Markers ◽  
Inhaled Corticosteroid

Relationship Between Phalangeal Bone Density and Risk of Vertebral Fracture

2002 ◽  
Vol 5 (1) ◽  
pp. 11-15 ◽  
Author(s):  
Misako Ohtsuka ◽  
Daniel Michaeli ◽  
Richard D. Wasnich
Keyword(s):  
Vertebral Fracture ◽  
Bone Density ◽  
Phalangeal Bone

Prevalence of vertebral fracture in women and the relationship with bone density and symptoms: The chingford study

2009 ◽  
Vol 8 (7) ◽  
pp. 817-822 ◽  
Author(s):  
Tim D. Spector ◽  
Eugene V. Mccloskey ◽  
David V. Doyle ◽  
John A. Kanis
Keyword(s):  
Vertebral Fracture ◽  
Bone Density ◽  
The Relationship

Bone Microarchitecture Assessment by High-Resolution Peripheral Quantitative Computed Tomography in Patients with Systemic Lupus Erythematosus Taking Corticosteroids

2010 ◽  
Vol 37 (7) ◽  
pp. 1473-1479 ◽  
Author(s):  
EDMUND K. LI ◽  
TRACY Y. ZHU ◽  
LAI-SHAN TAM ◽  
VIVIAN W. HUNG ◽  
JAMES F. GRIFFITH ◽  
...  
Keyword(s):  
Vertebral Fracture ◽  
Bone Density ◽  
Cortical Bone ◽  
Vertebral Fractures ◽  
Lupus Erythematosus ◽  
Bone Microarchitecture ◽  
Quantitative Computed Tomography ◽  
Peripheral Quantitative Computed Tomography ◽  
Cortical Bone Density ◽  
Chronic Corticosteroid

Objective.We assessed the relationship between vertebral fracture and bone microarchitecture in patients with systemic lupus erythematosus (SLE) on chronic corticosteroid therapy using high-resolution peripheral quantitative computed tomography (HR-pQCT).Methods.Fifty-nine Chinese women with SLE taking corticosteroid were selected to participate in a cross-sectional study. Vertebral fracture was confirmed semiquantitatively by lateral radiographs of the thoracic and lumbar spine. Density and microarchitecture at the distal radius were measured with HR-pQCT. Areal bone mineral density (aBMD) at hip and lumbar spine was measured by dual-energy x-ray absorptiometry (DEXA).Results.Twelve patients had vertebral fractures. The aBMD of spine or hip did not differ between those with and without vertebral fractures. Measures by HR-pQCT revealed that patients with vertebral fractures had significantly lower level of average bone density (p = 0.007), cortical bone density (p = 0.029), trabecular bone density (p = 0.024), trabecular bone volume to tissue volume (p = 0.023), and trabecular thickness (p = 0.011) than those without vertebral fractures. Independent explanatory variables associated with higher risk of vertebral fractures were older age (p = 0.013) and lower average cortical bone density (p = 0.029).Conclusion.Vertebral fracture in patients with SLE on chronic corticosteroid treatment was associated with alterations of bone density and microarchitectures measured by HR-pQCT and DEXA. However, alterations were more pronounced in measurements by HR-pQCT. Low cortical bone density and old age were significant predictors of vertebral fracture risk.

Sign in / Sign up

Export Citation Format

Share Document