Sucrose intake predicts rate of acquisition of cocaine self-administration

2000 ◽  
Vol 149 (3) ◽  
pp. 286-292 ◽  
Author(s):  
Blake A. Gosnell
Keyword(s):  
Sucrose Intake ◽  
Self Administration

scholarly journals Insulin acts at different CNS sites to decrease acute sucrose intake and sucrose self-administration in rats

2008 ◽  
Vol 295 (2) ◽  
pp. R388-R394 ◽  
Author(s):  
Dianne P. Figlewicz ◽  
Jennifer L. Bennett ◽  
Sepideh Aliakbari ◽  
Aryana Zavosh ◽  
Alfred J. Sipols
Keyword(s):  
Ventral Tegmental Area ◽  
Energy Homeostasis ◽  
Sucrose Intake ◽  
Palatable Food ◽  
Self Administration ◽  
Mu Opioid ◽  
Reward Function ◽  
Sucrose Feeding ◽  
Adiposity Signals ◽  
Ventral Tegmental

Findings from our laboratory and others have demonstrated that the hormone insulin has chronic effects within the CNS to regulate energy homeostasis and to decrease brain reward function. In this study, we compared the acute action of insulin to decrease intake of a palatable food in two different behavioral tasks—progressive ratios sucrose self-administration and mu opioid-stimulated sucrose feeding—when administered into several insulin-receptive sites of the CNS. We tested insulin efficacy within the medial hypothalamic arcuate (ARC) and paraventricular (PVN) nuclei, the nucleus accumbens, and the ventral tegmental area. Administration of insulin at a dose that has no chronic effect on body weight (5 mU) into the ARC significantly suppressed sucrose self-administration (75 ± 5% of paired control). However, although the mu opioid DAMGO, [d-Ala2,N-MePhe4,Gly5-ol]-enkephalin acetate salt, stimulated sucrose intake at all four CNS sites, the ventral tegmental area was the only sensitive site for a direct effect of insulin to antagonize acute (60 min) mu opioid-stimulated sucrose feeding: sucrose intake was 53 ± 8% of DAMGO-induced feeding, when insulin was coadministered with DAMGO. These findings demonstrate that free feeding of sucrose, and motivated work for sucrose, can be modulated within unique sites of the CNS reward circuitry. Further, they support the interpretation that adiposity signals, such as insulin, can decrease different aspects of ingestion of a palatable food, such as sucrose, in an anatomically specific manner.

Increased weight gain and sucrose intake during extinction of nicotine self-administration in adult male rats

2015 ◽  
Vol 146 ◽  
pp. e128
Author(s):  
Patricia Grebenstein ◽  
Danielle Burroughs ◽  
Christine Hernandez ◽  
Mark G. LeSage
Keyword(s):  
Weight Gain ◽  
Adult Male ◽  
Male Rats ◽  
Sucrose Intake ◽  
Self Administration

scholarly journals The effects of nicotine self-administration and withdrawal on concurrently available chow and sucrose intake in adult male rats

2016 ◽  
Vol 154 ◽  
pp. 49-59 ◽  
Author(s):  
Patricia E. Bunney ◽  
Danielle Burroughs ◽  
Christine Hernandez ◽  
Mark G. LeSage
Keyword(s):  
Adult Male ◽  
Male Rats ◽  
Sucrose Intake ◽  
Self Administration

Collection of Ego-Centered Network Data with Computer-Assisted Interviews

Methodology ◽  
2006 ◽  
Vol 2 (1) ◽  
pp. 7-15 ◽  
Author(s):  
Joachim Gerich ◽  
Roland Lehner
Keyword(s):  
Survey Methods ◽  
A Priori ◽  
Dynamic Structure ◽  
Computer Assisted ◽  
Network Data ◽  
Great Effort ◽  
Self Administration ◽  
Face To Face ◽  
Full Network

Although ego-centered network data provide information that is limited in various ways as compared with full network data, an ego-centered design can be used without the need for a priori and researcher-defined network borders. Moreover, ego-centered network data can be obtained with traditional survey methods. However, due to the dynamic structure of the questionnaires involved, a great effort is required on the part of either respondents (with self-administration) or interviewers (with face-to-face interviews). As an alternative, we will show the advantages of using CASI (computer-assisted self-administered interview) methods for the collection of ego-centered network data as applied in a study on the role of social networks in substance use among college students.

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