scholarly journals Correction to: Inhibition of a cortico-thalamic circuit attenuates cue-induced reinstatement of drug-seeking behavior in “relapse prone” male rats

2021 ◽  
Author(s):  
Brittany N. Kuhn ◽  
Paolo Campus ◽  
Marin S. Klumpner ◽  
Stephen E. Chang ◽  
Amanda G. Iglesias ◽  
...  
Keyword(s):  
Male Rats ◽  
Drug Seeking ◽  
Seeking Behavior

scholarly journals Inhibition of a cortico-thalamic circuit attenuates cue-induced reinstatement of drug-seeking behavior in “relapse prone” male rats

2020 ◽  
Author(s):  
Brittany N. Kuhn ◽  
Paolo Campus ◽  
Marin S. Klumpner ◽  
Stephen E. Chang ◽  
Amanda G. Iglesias ◽  
...  
Keyword(s):  
Individual Differences ◽  
Male Rats ◽  
Incentive Salience ◽  
Top Down ◽  
Drug Induced ◽  
Drug Seeking ◽  
Drug Cues ◽  
Cortical Input ◽  
Incentive Value ◽  
Seeking Behavior

AbstractRelapse often occurs when individuals are exposed to stimuli or cues previously associated with the drug-taking experience. The ability of drug cues to trigger relapse is believed to be a consequence of incentive salience attribution, a process by which the incentive value of reward is transferred to the reward-paired cue. Sign-tracker (ST) rats that attribute enhanced incentive value to reward cues are more prone to relapse compared to goal-tracker (GT) rats that primarily attribute predictive value to such cues. The neurobiological mechanisms underlying this individual variation in relapse propensity remains largely unexplored. The paraventricular nucleus of the thalamus (PVT) has been identified as a critical node in the regulation of cue-elicited behaviors in STs and GTs, including cue-induced reinstatement of drug-seeking behavior. Here we used a chemogenetic approach to assess whether “top-down” cortical input from the prelimbic cortex (PrL) to the PVT plays a role in mediating individual differences in relapse propensity. Chemogenetic inhibition of the PrL-PVT pathway selectively decreased cue-induced reinstatement of drug-seeking behavior in STs, without affecting behavior in GTs. In contrast, cocaine-primed drug-seeking behavior was not affected in either phenotype. Furthermore, when rats were characterized based on a different behavioral phenotype – locomotor response to novelty – inhibition of the PrL-PVT pathway had no effect on either cue- or drug-induced reinstatement. These results highlight an important role for the PrL-PVT pathway in vulnerability to relapse that is driven by individual differences in the propensity to attribute incentive salience to discrete reward cues.

scholarly journals Do Prenatally Methamphetamine-Exposed Adult Male Rats Display General Predisposition to Drug Abuse in the Conditioned Place Preference Test?

2012 ◽  
pp. S129-S138
Author(s):  
R. ŠLAMBEROVÁ ◽  
M. POMETLOVÁ ◽  
B. SCHUTOVÁ ◽  
L. HRUBÁ ◽  
E. MACÚCHOVÁ ◽  
...  
Keyword(s):  
Drug Abuse ◽  
Pregnant Women ◽  
Conditioned Place Preference ◽  
Adult Male ◽  
Place Preference ◽  
Male Rats ◽  
Self Administration ◽  
Adult Rats ◽  
Drug Seeking ◽  
Seeking Behavior

Drug abuse of pregnant women is a growing problem. The effect of prenatal drug exposure may have devastating effect on development of the offsprings that may be long-term or even permanent. One of the most common drug abused by pregnant women is methamphetamine (MA), which is also the most frequently abused illicit drug in the Czech Republic. Our previous studies demonstrated that prenatal MA exposure alters behavior, cognition, pain and seizures in adult rats in sex-specific manner. Our most recent studies demonstrate that prenatal MA exposure makes adult rats more sensitive to acute injection of the same or related drugs than their controls. The aim of the present study was to examine the effect of prenatal MA exposure on drug-seeking behavior of adult male rats tested in the Conditioned place preference (CPP). Adult male rats were divided to: prenatally MA-exposed (5 mg/kg daily for the entire prenatal period), prenatally saline-exposed (1 ml/kg of physiological saline) and controls (without maternal injections). The following drugs were used in the CPP test in adulthood: MA (5 mg/kg), amphetamine (5 mg/kg), cocaine (5 and 10 mg/kg), morphine (5 mg/kg), MDMA (5 mg/kg) and THC (2 mg/kg). Our data demonstrated that prenatally MA-exposed rats displayed higher amphetamine-seeking behavior than both controls. MA as well as morphine induced drug-seeking behavior of adult male rats, however this effect did not differ based on the prenatal MA exposure. In contrast, prenatal MA exposure induced rather tolerance to cocaine than sensitization after the conditioning in the CPP. MDMA and THC did not induce significant effects. Even though the present data did not fully confirmed our hypotheses, future studies are planned to test the drug-seeking behavior also in self-administration test.

scholarly journals Methamphetamine self-administration in a runway model of drug-seeking behavior in male rats

2018 ◽  
Vol 175 ◽  
pp. 27-32
Author(s):  
Mona Akhiary ◽  
Erin M. Purvis ◽  
Adam K. Klein ◽  
Aaron Ettenberg
Keyword(s):  
Male Rats ◽  
Self Administration ◽  
Drug Seeking ◽  
Seeking Behavior

Does prenatal methamphetamine exposure affect the drug-seeking behavior of adult male rats?

2011 ◽  
Vol 224 (1) ◽  
pp. 80-86 ◽  
Author(s):  
Romana Šlamberová ◽  
Barbora Schutová ◽  
Lenka Hrubá ◽  
Marie Pometlová
Keyword(s):  
Adult Male ◽  
Male Rats ◽  
Drug Seeking ◽  
Seeking Behavior

scholarly journals Does Prenatal Methamphetamine Exposure Induce Cross-sensitization to Cocaine and Morphine in Adult Male Rats?

2012 ◽  
Vol 113 (3) ◽  
pp. 189-205 ◽  
Author(s):  
Romana Šlamberová ◽  
A. Yamamotová ◽  
M. Pometlová ◽  
B. Schutová ◽  
L. Hrubá ◽  
...  
Keyword(s):  
Adult Male ◽  
Analgesic Effect ◽  
Drug Exposure ◽  
Prenatal Drug Exposure ◽  
Male Rats ◽  
Daily Injection ◽  
Challenge Dose ◽  
Drug Seeking ◽  
Seeking Behavior ◽  
Plantar Test

The aim of the present study was to examine the cross-sensitization induced by prenatal methamphetamine (MA) exposure to challenge dose of cocaine or morphine. Rat mothers received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male offspring (prenatally MA- or saline-exposed) were divided to groups with challenge doses of saline (1 ml/kg), cocaine (5 mg/kg) or morphine (5 mg/kg). Behavior in unknown environment was examined in Laboras, nociception in Plantar test, and active drug-seeking behavior in conditioned place preference (CPP). Our data demonstrate that cocaine increased the exploratory activity in Laboras test in prenatally saline-exposed, but decreased it in prenatally MA-exposed rats. An analgesic effect of cocaine was demonstrated only by the tail withdrawal and it was independent of the prenatal drug exposure. CPP test showed that prenatal MA exposure induced rather tolerance than sensitization to cocaine. In contrast to cocaine effects, morphine decreased rearing activity in both, prenatally MA-exposed and saline-exposed rats, and locomotion only in prenatally MA-exposed rats in the Laboras. In the Plantar test, the results demonstrated that morphine had an analgesic effect in prenatally saline-exposed rats but this effect was suppressed in prenatally MA-exposed rats. In the CPP test morphine induced drug-seeking behavior, which however was not affected by prenatal drug exposure. Thus, our data demonstrate that there is a cross-effect between prenatal MA exposure and the challenge dose of other drug in adulthood, however drug-seeking behavior is not increased by prenatal MA exposure as we expected.

Inhibition of a cortico-thalamic circuit attenuates cue-induced reinstatement of drug-seeking behavior in “relapse prone” male rats

2021 ◽  
Author(s):  
Brittany N. Kuhn ◽  
Paolo Campus ◽  
Marin S. Klumpner ◽  
Stephen E. Chang ◽  
Amanda G. Iglesias ◽  
...  
Keyword(s):  
Male Rats ◽  
Drug Seeking ◽  
Seeking Behavior

Care plans reduce ED visits in those with drug-seeking behavior

2015 ◽  
Vol 33 (12) ◽  
pp. 1799-1801 ◽  
Author(s):  
Frederick Fiesseler ◽  
Renee Riggs ◽  
David Salo ◽  
Richard Klemm ◽  
Ashley Flannery ◽  
...  
Keyword(s):  
Drug Seeking ◽  
Care Plans ◽  
Seeking Behavior ◽  
Ed Visits
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