Acute Effects of Low Doses of Zineb and Ethylenethiourea on Thyroid Function in the Male Rat

1996 ◽  
Vol 56 (5) ◽  
pp. 847-852 ◽  
Author(s):  
C. Nebbia ◽  
J. Fink-Gremmels
Keyword(s):  
Thyroid Function ◽  
Male Rat ◽  
Low Doses ◽  
Acute Effects

scholarly journals Antifertility Actions of a-Chlorohydrin in the Male

1983 ◽  
Vol 36 (4) ◽  
pp. 333 ◽  
Author(s):  
A RJones
Keyword(s):  
Male Fertility ◽  
Human Sperm ◽  
Male Rat ◽  
Low Doses ◽  
Dose Regime ◽  
Male Contraceptive ◽  
The Past ◽  
High Doses ◽  
Species Specific ◽  
Daily Oral Administration

Non-steroidal chemicals that affect male fertility have been known for over 25 years but only one compound, oc-chlorohydrin, possesses most of the attributes of an ideal male contraceptive. In the male rat, for example, continuous daily oral administration of low doses produces an almost immediate and continuous antifertility response that ceases when treatment is withdrawn. Such a dose regime does not interfere with libido, is apparently not toxic and the action is specific towards mature sperm. Furthermore, the action of the compound is species-specific: it is effective in the rat, ram, boar, guinea pig, hamster,rhesus monkey and upon ejaculated human sperm but it is ineffective in the mouse and the rabbit. High doses of oc-chlorohydrin can be neurotoxic, nephrotoxic and, in rats, lead to prolonged or permanent infertility. However, the antifertility response and the toxicity of racemic oc-chlorohydrin may be due, respectively, to the separate enantiomers. No other antifertility chemical has been investigated to such an extent as oc-chlorohydrin; this article reviews the progress that has been achieved with oc-chlorohydrin during the past six years.

CO2 and bicarbonate exchange in the rat liver

1988 ◽  
Vol 65 (6) ◽  
pp. 2736-2743 ◽  
Author(s):  
B. Lipsen ◽  
R. M. Effros
Keyword(s):  
Portal Vein ◽  
Hepatic Vein ◽  
Ph Value ◽  
Sex Steroid ◽  
Male Rat ◽  
Cellular Distribution ◽  
Low Doses ◽  
Hepatic Lobule ◽  
Hepatic Cells ◽  
Rat Livers

Several forms of carbonic anhydrase (CA) have been detected in hepatocytes. The distribution of these enzymes appears to be heterogeneous in the hepatic lobule, and the specific isoenzyme that predominates is influenced by sex steroid levels in the animal. In the present study, experiments were conducted in isolated male rat livers perfused with erythrocyte-free solutions, which were devoid of CA to see if there were sufficient tissue CA activity accessible to the plasma to ensure equilibration between labeled HCO3- and CO2 during a single passage from the portal vein to the hepatic vein. After injection of H14CO3- into the portal vein, emergence of the 14C label from the hepatic vein was slightly more rapid than after injections of 14CO2. After infusion of 5-250 microM of acetazolamide, an inhibitor of CA, H14CO3- was virtually confined to the extracellular space during a single transit through the organ, whereas the outflow of 14CO2 was very prolonged, suggesting that some of the 14C had been "trapped" within the hepatic cells as H14CO3-. Inhibition of CA activity in the intact organ with low doses of acetazolamide suggests the presence of a readily inhibitable isoenzyme of CA on the surface of the hepatocytes, which is directly accessible to both HCO3- and acetazolamide. The outflow patterns of 14CO2 and H14CO3- became the same after infusion of erythrocyte CA into the portal vein. On the basis of the pH of the perfusate and the cellular distribution of 14CO2 and H14CO3- in the presence of CA, an intracellular pH value of 7.26 was calculated.(ABSTRACT TRUNCATED AT 250 WORDS)

ACUTE EFFECTS OF LOW DOSES OF CLOMIPRAMINE ON ISOLATION-INDUCED AGGRESSION IN MALE MICE

1992 ◽  
Vol 3 (Supplement) ◽  
pp. 42
Author(s):  
J J BORRAS-VALLS ◽  
A SALVADOR ◽  
V M SIMON
Keyword(s):  
Low Doses ◽  
Male Mice ◽  
Acute Effects

Acute Effects of Arginine Vasotocin on Plasma and Pituitary Levels of Prolactin in the Male Rat: Influence of Urethane Anesthesia

1980 ◽  
Vol 13 (2) ◽  
pp. 109-120 ◽  
Author(s):  
Linda Y Johnson ◽  
Mary K Vaughan ◽  
Russel J. Reiter ◽  
Larry J. Petterborg ◽  
Hsien-jen Chen
Keyword(s):  
Arginine Vasotocin ◽  
Male Rat ◽  
Acute Effects ◽  
Urethane Anesthesia

Orphenadrine citrate (Norflex®) mediated inhibition of thyroid function in the adult male rat

1981 ◽  
Vol 4 (2) ◽  
pp. 141-147
Author(s):  
A. J. Van Herle ◽  
N. Panagiotis ◽  
R. Naruse ◽  
L. Freisleben ◽  
H. M. L. Van Herle
Keyword(s):  
Thyroid Function ◽  
Adult Male ◽  
Male Rat ◽  
Adult Male Rat

scholarly journals Effects of Maternal Exposure to Low Doses of DES on Testicular Steroidogenesis and Spermatogenesis in Male Rat Offspring

2009 ◽  
Vol 55 (6) ◽  
pp. 629-637 ◽  
Author(s):  
Tetsuo KOBAYASHI ◽  
Mitsuyuki SHIRAI ◽  
Motoharu SAKAUE ◽  
Masaru MURAKAMI ◽  
Hideharu OCHIAI ◽  
...  
Keyword(s):  
Maternal Exposure ◽  
Male Rat ◽  
Low Doses ◽  
Rat Offspring ◽  
Testicular Steroidogenesis
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