Acute Toxicity of Two Compounds with Different Modes of Action to the Zebrafish, Danio rerio

2002 ◽  
Vol 68 (2) ◽  
pp. 269-274
Author(s):  
E. W. M. Roex ◽  
M. C. T. van Langen ◽  
C. A. M. van Gestel
Keyword(s):  
Acute Toxicity ◽  
Danio Rerio ◽  
Modes Of Action

Acute toxicity of organic chemicals to Gammarus pulex correlates with sensitivity of Daphnia magna across most modes of action

2011 ◽  
Vol 103 (1-2) ◽  
pp. 38-45 ◽  
Author(s):  
Roman Ashauer ◽  
Anita Hintermeister ◽  
Eva Potthoff ◽  
Beate I. Escher
Keyword(s):  
Acute Toxicity ◽  
Daphnia Magna ◽  
Gammarus Pulex ◽  
Organic Chemicals ◽  
Modes Of Action

scholarly journals Libidibia ferrea (jucá), a Traditional Anti-Inflammatory: A Study of Acute Toxicity in Adult and Embryos Zebrafish (Danio rerio)

2019 ◽  
Vol 12 (4) ◽  
pp. 175 ◽  
Author(s):  
Diego Q. Ferreira ◽  
Thamara O. Ferraz ◽  
Raquel S. Araújo ◽  
Rodrigo Alves Souza Cruz ◽  
Caio Pinho Fernandes ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Medicinal Product ◽  
Plant Species ◽  
Danio Rerio ◽  
Folk Medicine ◽  
Cellular Level ◽  
High Concentration ◽  
Phytochemical Composition ◽  
Inflammatory Processes ◽  
Hydroethanolic Extract

The plant species Libidibia ferrea (Mart. ex Tul.) LP Queiroz var. ferrea basionym of Caesalpinia ferrea (Mart. ex Tul.) is used in various regions of Brazil in folk medicine in the treatment of several health problems, especially in acute and chronic inflammatory processes. Most of the preparations employed are alcoholic. Therefore, this study aimed to evaluate the acute toxicity of the hydroethanolic extract of fruits of Libidibia ferrea (EHEFLf) in zebrafish, emphasizing the possible changes in the organic-cellular level of the gills, liver, kidneys, and intestine and on embryos. The result obtained by LC-M/MS from EHEFLf indicated a high concentration of possible polyhydroxylated substances. EHEFLf, at a dose of 2 g/kg orally, produced non-significant alterations of the analyzed organs. However, for embryos, the treatment with different concentrations demonstrated heart toxicity that was concentration-dependent. There is no evidence of a correlation of the observed effects with the phytochemical composition, and considering the species of animal used, it can be suggested that the oral use of L. ferrea hydroethanolic extract has an acceptable degree of safety for use as an oral medicinal product. and embryo results have shown significant affinity to the heart; however, it is perceived to be related to the concentrations used.

The Index of Ideality of Correlation: QSAR Model of Acute Toxicity for Zebrafish (Danio rerio) Embryo

2019 ◽  
Vol 13 (2) ◽  
pp. 387-394 ◽  
Author(s):  
Andrey Andreevich Toropov ◽  
Alla Petrovna Toropova ◽  
Emilio Benfenati
Keyword(s):  
Acute Toxicity ◽  
Danio Rerio ◽  
Qsar Model

scholarly journals Acute toxicity, bioconcentration, elimination, action mode and detoxification metabolism of broflanilide in zebrafish, Danio rerio

2020 ◽  
Vol 394 ◽  
pp. 122521 ◽  
Author(s):  
Zhong-Qiang Jia ◽  
Yi-Chi Zhang ◽  
Qiu-Tang Huang ◽  
Andrew K. Jones ◽  
Zhao-Jun Han ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Danio Rerio ◽  
Action Mode
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