Effect of Nanoparticle Stabilization and Physicochemical Properties on Exposure Outcome: Acute Toxicity of Silver Nanoparticle Preparations in Zebrafish (Danio rerio)

2013 ◽  
Vol 47 (8) ◽  
pp. 3883-3892 ◽  
Author(s):  
Stephen Cunningham ◽  
Margaret E. Brennan-Fournet ◽  
Deirdre Ledwith ◽  
Lucy Byrnes ◽  
Lokesh Joshi
Keyword(s):  
Acute Toxicity ◽  
Physicochemical Properties ◽  
Silver Nanoparticle ◽  
Danio Rerio ◽  
Nanoparticle Stabilization

scholarly journals Chemometric Evaluation of the Link between Acute Toxicity, Health Issues and Physicochemical Properties of Silver Nanoparticles

Symmetry ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1159 ◽  
Author(s):  
Nedyalkova ◽  
Dimitrov ◽  
Donkova ◽  
Simeonov
Keyword(s):  
Acute Toxicity ◽  
Zeta Potential ◽  
Physicochemical Properties ◽  
Silver Nanoparticle ◽  
Physicochemical Parameters ◽  
Bactericidal Effect ◽  
Wide Distribution ◽  
Multivariate Statistical ◽  
Data Set ◽  
Environmental Media

The present study’s objective is to focus on some developments in the field of statistical models of a complex system, like nanoparticles responses in the environmental media. An important problem that still needs to be studied and interpreted is the relations between physicochemical parameters of the nanoparticles like primary size, primary hydrophobic diameter, zeta potential, etc. with respective toxicity values. It holds true especially for silver nanoparticle systems due to their known bactericidal effect and wide distribution in practice. The present study deals with the data for physicochemical and toxicity parameters of 94 different silver nanoparticle systems in order to reveal specific relations between physicochemical properties and acute toxicity readings using multivariate statistical methods. Searching for these specific relationships between physicochemical parameters and toxicity responses is the novel element in the present study. This has focused our study toward developing a model that describes the relationship between physicochemical properties and toxicity of silver NPs based on a dataset gathered from the literature. It is shown that the systems studied could be divided into four patterns (clusters) of similarity depending not only on the physicochemical indicators related to particles size but also by their acute toxicity. The acute toxicity is strongly correlated to the zeta potential of the particles if the whole data set is considered.

scholarly journals Toxicological Profile of Plasmonic Nanoparticles in Zebrafish Model

2021 ◽  
Vol 22 (12) ◽  
pp. 6372
Author(s):  
Marta d’Amora ◽  
Vittoria Raffa ◽  
Francesco De Angelis ◽  
Francesco Tantussi
Keyword(s):  
Surface Plasmon Resonance ◽  
Adverse Effects ◽  
Physicochemical Properties ◽  
Surface Plasmon ◽  
Danio Rerio ◽  
Plasmonic Nanoparticles ◽  
Comprehensive Understanding ◽  
Zebrafish Model ◽  
Toxicological Profile ◽  
Materials Used

Plasmonic nanoparticles are increasingly employed in several fields, thanks to their unique, promising properties. In particular, these particles exhibit a surface plasmon resonance combined with outstanding absorption and scattering properties. They are also easy to synthesize and functionalize, making them ideal for nanotechnology applications. However, the physicochemical properties of these nanoparticles can make them potentially toxic, even if their bulk metallic forms are almost inert. In this review, we aim to provide a more comprehensive understanding of the potential adverse effects of plasmonic nanoparticles in zebrafish (Danio rerio) during both development and adulthood, focusing our attention on the most common materials used, i.e., gold and silver.

TOXICITY STUDIES ON SILVER AND COPPER NANOPARTICLES

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (09) ◽  
pp. 58-60
Author(s):  
P Samuel ◽  
◽  
B Pavithra ◽  
R. Priyadarshini ◽  
V. Maheswari ◽  
...  
Keyword(s):  
Atomic Absorption ◽  
Copper Nanoparticles ◽  
Silver Nanoparticle ◽  
Danio Rerio ◽  
Atomic Absorption Spectroscopy ◽  
Pilot Scale ◽  
Zebra Fish ◽  
Ventral Region ◽  
Plant Sources

In a pilot scale study, silver and copper nanoparticles were synthesized from two different plant sources viz Flacourtia indica and Prosopsis juliflora. The in vivo toxicity of silver and copper nanoparticles was tested on Danio rerio (Zebra fish) under different concentrations (1 ppm, 10 ppm and 100 ppm). Through the investigation, the nanoparticles treated fishes developed with hyper pigmentation in the ventral region. The minimum lethal concentration required to bring lethality caused by silver nanoparticle was 10 ppm whereas for copper nanoparticles it was 1 ppm. Further, the concentration of silver and copper nanoparticles accumulated inside the fish was evaluated by Atomic Absorption Spectroscopy. The in vivo concentration of silver and copper nanoparticles steadily increases with increase in dosage of nanoparticles being tested.

scholarly journals Libidibia ferrea (jucá), a Traditional Anti-Inflammatory: A Study of Acute Toxicity in Adult and Embryos Zebrafish (Danio rerio)

2019 ◽  
Vol 12 (4) ◽  
pp. 175 ◽  
Author(s):  
Diego Q. Ferreira ◽  
Thamara O. Ferraz ◽  
Raquel S. Araújo ◽  
Rodrigo Alves Souza Cruz ◽  
Caio Pinho Fernandes ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Medicinal Product ◽  
Plant Species ◽  
Danio Rerio ◽  
Folk Medicine ◽  
Cellular Level ◽  
High Concentration ◽  
Phytochemical Composition ◽  
Inflammatory Processes ◽  
Hydroethanolic Extract

The plant species Libidibia ferrea (Mart. ex Tul.) LP Queiroz var. ferrea basionym of Caesalpinia ferrea (Mart. ex Tul.) is used in various regions of Brazil in folk medicine in the treatment of several health problems, especially in acute and chronic inflammatory processes. Most of the preparations employed are alcoholic. Therefore, this study aimed to evaluate the acute toxicity of the hydroethanolic extract of fruits of Libidibia ferrea (EHEFLf) in zebrafish, emphasizing the possible changes in the organic-cellular level of the gills, liver, kidneys, and intestine and on embryos. The result obtained by LC-M/MS from EHEFLf indicated a high concentration of possible polyhydroxylated substances. EHEFLf, at a dose of 2 g/kg orally, produced non-significant alterations of the analyzed organs. However, for embryos, the treatment with different concentrations demonstrated heart toxicity that was concentration-dependent. There is no evidence of a correlation of the observed effects with the phytochemical composition, and considering the species of animal used, it can be suggested that the oral use of L. ferrea hydroethanolic extract has an acceptable degree of safety for use as an oral medicinal product. and embryo results have shown significant affinity to the heart; however, it is perceived to be related to the concentrations used.

The Index of Ideality of Correlation: QSAR Model of Acute Toxicity for Zebrafish (Danio rerio) Embryo

2019 ◽  
Vol 13 (2) ◽  
pp. 387-394 ◽  
Author(s):  
Andrey Andreevich Toropov ◽  
Alla Petrovna Toropova ◽  
Emilio Benfenati
Keyword(s):  
Acute Toxicity ◽  
Danio Rerio ◽  
Qsar Model
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