scholarly journals Oophorectomy promotes islet amyloid formation in a transgenic mouse model of Type II diabetes

Diabetologia ◽  
2000 ◽  
Vol 43 (10) ◽  
pp. 1309-1312 ◽  
Author(s):  
S. E. Kahn ◽  
S. Andrikopoulos ◽  
C. B. Verchere ◽  
F. Wang ◽  
R. L. Hull ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Type Ii Diabetes ◽  
Transgenic Mouse Model ◽  
Amyloid Formation ◽  
Type Ii ◽  
Islet Amyloid

Increased Dietary Fat Promotes Islet Amyloid Formation and  -Cell Secretory Dysfunction in a Transgenic Mouse Model of Islet Amyloid

Diabetes ◽  
2003 ◽  
Vol 52 (2) ◽  
pp. 372-379 ◽  
Author(s):  
R. L. Hull ◽  
S. Andrikopoulos ◽  
C. B. Verchere ◽  
J. Vidal ◽  
F. Wang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Dietary Fat ◽  
Transgenic Mouse Model ◽  
Amyloid Formation ◽  
Islet Amyloid

scholarly journals Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model

Diabetologia ◽  
1999 ◽  
Vol 42 (4) ◽  
pp. 427-434 ◽  
Author(s):  
J. W. M. Höppener ◽  
C. Oosterwijk ◽  
M. G. Nieuwenhuis ◽  
G. Posthuma ◽  
J. H. H. Thijssen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Mouse Model ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Amyloid Formation ◽  
Type Ii ◽  
Islet Amyloid

scholarly journals Mechanistic Contributions of Biological Cofactors in Islet Amyloid Polypeptide Amyloidogenesis

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Phuong Trang Nguyen ◽  
Nagore Andraka ◽  
Carole Anne De Carufel ◽  
Steve Bourgault
Keyword(s):  
Type Ii Diabetes ◽  
Amyloid Fibrils ◽  
Driving Forces ◽  
Islet Amyloid Polypeptide ◽  
Type Ii Diabetes Mellitus ◽  
Major Protein ◽  
Local Concentration ◽  
Amyloid Formation ◽  
Type Ii ◽  
Islet Amyloid

Type II diabetes mellitus is associated with the deposition of fibrillar aggregates in pancreatic islets. The major protein component of islet amyloids is the glucomodulatory hormone islet amyloid polypeptide (IAPP). Islet amyloid fibrils are virtually always associated with several biomolecules, including apolipoprotein E, metals, glycosaminoglycans, and various lipids. IAPP amyloidogenesis has been originally perceived as a self-assembly homogeneous process in which the inherent aggregation propensity of the peptide and its local concentration constitute the major driving forces to fibrillization. However, over the last two decades, numerous studies have shown a prominent role of amyloid cofactors in IAPP fibrillogenesis associated with the etiology of type II diabetes. It is increasingly evident that the biochemical microenvironment in which IAPP amyloid formation occurs and the interactions of the polypeptide with various biomolecules not only modulate the rate and extent of aggregation, but could also remodel the amyloidogenesis process as well as the structure, toxicity, and stability of the resulting fibrils.

Islet amyloid inhibitors improve glucose homeostasis in a transgenic mouse model of type 2 diabetes

2015 ◽  
Vol 17 (10) ◽  
pp. 1003-1006 ◽  
Author(s):  
N. Wijesekara ◽  
R. Ahrens ◽  
L. Wu ◽  
K. Ha ◽  
Y. Liu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Glucose Homeostasis ◽  
Transgenic Mouse Model ◽  
Islet Amyloid

miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF-β type II receptor

2010 ◽  
Vol 1357 ◽  
pp. 166-174 ◽  
Author(s):  
Hailin Wang ◽  
Jialin Liu ◽  
Yuanyuan Zong ◽  
Yanfeng Xu ◽  
Wei Deng ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Type Ii ◽  
Double Transgenic Mouse
Sign in / Sign up

Export Citation Format

Share Document