The Development and Characterization of a Transgenic Mouse Model Over-Expressing a Truncated TGF(Beta) Type II Receptor in the Prostate

2000 ◽  
Author(s):  
Tania Thomas ◽  
S. Shappell ◽  
S. Kasper ◽  
R. A. Serra ◽  
H. L. Moses
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Type Ii ◽  
Tgf Beta

Metabolic Characterization of the R6/2 Transgenic Mouse Model of Huntington's Disease by High-Resolution MAS1H NMR Spectroscopy

2006 ◽  
Vol 5 (3) ◽  
pp. 483-492 ◽  
Author(s):  
Tsz M. Tsang ◽  
Ben Woodman ◽  
Gerard A. Mcloughlin ◽  
Julian L. Griffin ◽  
Sarah J. Tabrizi ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
High Resolution ◽  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model

Generation and characterization of a transgenic mouse model with hepatic expression of human CYP2A6

2005 ◽  
Vol 338 (1) ◽  
pp. 318-324 ◽  
Author(s):  
Qing-Yu Zhang ◽  
Jun Gu ◽  
Ting Su ◽  
Huadong Cui ◽  
Xiuling Zhang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Hepatic Expression

scholarly journals Biochemical and behavioral characterization of the double transgenic mouse model (APPswe/PS1dE9) of Alzheimer’s disease

2011 ◽  
Vol 27 (4) ◽  
pp. 221-232 ◽  
Author(s):  
Huaqi Xiong ◽  
Debbie Callaghan ◽  
Jolanta Wodzinska ◽  
Jiejing Xu ◽  
Maryna Premyslova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Double Transgenic Mouse ◽  
Behavioral Characterization

scholarly journals Characterization of a transgenic mouse model exhibiting spontaneous lung adenocarcinomas with a metastatic phenotype

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0175586 ◽  
Author(s):  
Hsuen-Wen Chang ◽  
Zih-Miao Lin ◽  
Min-Ju Wu ◽  
Li-Yu Wang ◽  
Yen-Hung Chow ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Metastatic Phenotype ◽  
Lung Adenocarcinomas

scholarly journals The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model

Blood ◽  
2010 ◽  
Vol 115 (16) ◽  
pp. 3341-3345 ◽  
Author(s):  
Ke Cheng ◽  
Paolo Sportoletti ◽  
Keisuke Ito ◽  
John G. Clohessy ◽  
Julie Teruya-Feldstein ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Mouse Model ◽  
Transgenic Mice ◽  
Transgenic Mouse ◽  
Myeloid Leukemia ◽  
Gene Mutations ◽  
Transgenic Mouse Model ◽  
Acute Myeloid

Abstract Although NPM1 gene mutations leading to aberrant cytoplasmic expression of nucleophosmin (NPMc+) are the most frequent genetic lesions in acute myeloid leukemia, there is yet no experimental model demonstrating their oncogenicity in vivo. We report the generation and characterization of a transgenic mouse model expressing the most frequent human NPMc+ mutation driven by the myeloid-specific human MRP8 promoter (hMRP8-NPMc+). In parallel, we generated a similar wild-type NPM trans-genic model (hMRP8-NPM). Interestingly, hMRP8-NPMc+ transgenic mice developed myeloproliferation in bone marrow and spleen, whereas nontransgenic littermates and hMRP8-NPM transgenic mice remained disease free. These findings provide the first in vivo evidence indicating that NPMc+ confers a proliferative advantage in the myeloid lineage. No spontaneous acute myeloid leukemia was found in hMPR8-NPMc+ or hMRP8-NPM mice. This model will also aid in the development of therapeutic regimens that specifically target NPMc+.

scholarly journals Molecular characterization of salivary gland malignancy using the Smgb-Tag transgenic mouse model

2005 ◽  
Vol 85 (8) ◽  
pp. 947-961 ◽  
Author(s):  
Antti A Mäkitie ◽  
Patricia Pintor dos Reis ◽  
Shilpi Arora ◽  
Christina MacMillan ◽  
Giles C Warner ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Molecular Characterization ◽  
Transgenic Mouse Model ◽  
Salivary Gland Malignancy
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