scholarly journals The effect of vanadyl treatment on vascular responsiveness of streptozotocin-diabetic rats

Diabetologia ◽  
1994 ◽  
Vol 37 (6) ◽  
pp. 572-578 ◽  
Author(s):  
A. T. �z�elikay ◽  
C. Pekiner ◽  
N. Ari ◽  
Y. �zt�rk ◽  
A. �z�ari ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Vascular Responsiveness ◽  
Streptozotocin Diabetic Rats

scholarly journals The effects of chronic L-arginine treatment on vascular responsiveness of streptozotocin-diabetic rats

1999 ◽  
Vol 33 (4) ◽  
pp. 299-306 ◽  
Author(s):  
A.Tanju Özçelikay ◽  
Aydin Tay ◽  
Deniz Dinçer ◽  
Suna Meral ◽  
Nuray Yildizoğlu-Ari ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Vascular Responsiveness ◽  
Streptozotocin Diabetic Rats

Blood pressure and heart rate response to vasoactive agents in conscious diabetic rats

1992 ◽  
Vol 70 (12) ◽  
pp. 1542-1548 ◽  
Author(s):  
Zhen Yu ◽  
John H. McNeill
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Vascular System ◽  
Femoral Vein ◽  
Diabetic Rats ◽  
Vasoactive Agents ◽  
Lower Systolic Blood Pressure ◽  
Vascular Responsiveness ◽  
Streptozotocin Diabetic Rats ◽  
Vasodepressor Response

Blood pressure and heart rate responses to different vasoactive agents were observed in conscious streptozotocin-diabetic rats. An indwelling femoral artery catheter was used for direct measurement of arterial pressure and heart rate. The femoral vein was cannulated for drug administration. In a resting state diabetic rats showed lower heart rates and lower systolic blood pressure. The vasodepressor response to both acetylcholine and sodium nitroprasside was decreased, while the heart rate increase induced by the baroreceptor reflex was not altered. Both the increase in blood pressure and the reflex bradycardia to norepinephrine were decreased in the diabetic group. When the change in heart rate was plotted against blood pressure in response to norepinephrine, there was no difference in the two groups of animals. The vasodepressor response to isoproterenol, hydralazine, and verapamil in diabetic rats was unchanged. The results demonstrate a decreased vascular responsiveness in diabetic rats to norepinephrine, acetylcholine, and nitroprusside. The diabetes-induced vascular system changes require further study to understand the mechanisms involved.Key words: diabetes, blood pressure, acetylcholine, sodium nitroprusside, norepinephrine, isoproterenol, hydralazine, verapamil.

scholarly journals The effect of vanadyl treatment on vascular responsiveness of streptozotocin-diabetic rats

Diabetologia ◽  
1994 ◽  
Vol 37 (6) ◽  
pp. 572-578 ◽  
Author(s):  
A. T. �z�elikay ◽  
C. Pekiner ◽  
N. Ari ◽  
Y. �zt�rk ◽  
A. �z�ari ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Vascular Responsiveness ◽  
Streptozotocin Diabetic Rats
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