REVERSAL EFFECTS OF ? -ARGININE TREATMENT ON BLOOD PRESSURE AND VASCULAR RESPONSIVENESS OF STREPTOZOTOCIN-DIABETIC RATS

2000 ◽  
Vol 41 (2) ◽  
pp. 201-209 ◽  
Author(s):  
A ÖZCELIKAY
Keyword(s):  
Blood Pressure ◽  
Diabetic Rats ◽  
Vascular Responsiveness ◽  
Streptozotocin Diabetic Rats

Blood pressure and heart rate response to vasoactive agents in conscious diabetic rats

1992 ◽  
Vol 70 (12) ◽  
pp. 1542-1548 ◽  
Author(s):  
Zhen Yu ◽  
John H. McNeill
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Vascular System ◽  
Femoral Vein ◽  
Diabetic Rats ◽  
Vasoactive Agents ◽  
Lower Systolic Blood Pressure ◽  
Vascular Responsiveness ◽  
Streptozotocin Diabetic Rats ◽  
Vasodepressor Response

Blood pressure and heart rate responses to different vasoactive agents were observed in conscious streptozotocin-diabetic rats. An indwelling femoral artery catheter was used for direct measurement of arterial pressure and heart rate. The femoral vein was cannulated for drug administration. In a resting state diabetic rats showed lower heart rates and lower systolic blood pressure. The vasodepressor response to both acetylcholine and sodium nitroprasside was decreased, while the heart rate increase induced by the baroreceptor reflex was not altered. Both the increase in blood pressure and the reflex bradycardia to norepinephrine were decreased in the diabetic group. When the change in heart rate was plotted against blood pressure in response to norepinephrine, there was no difference in the two groups of animals. The vasodepressor response to isoproterenol, hydralazine, and verapamil in diabetic rats was unchanged. The results demonstrate a decreased vascular responsiveness in diabetic rats to norepinephrine, acetylcholine, and nitroprusside. The diabetes-induced vascular system changes require further study to understand the mechanisms involved.Key words: diabetes, blood pressure, acetylcholine, sodium nitroprusside, norepinephrine, isoproterenol, hydralazine, verapamil.

scholarly journals The effects of chronic L-arginine treatment on vascular responsiveness of streptozotocin-diabetic rats

1999 ◽  
Vol 33 (4) ◽  
pp. 299-306 ◽  
Author(s):  
A.Tanju Özçelikay ◽  
Aydin Tay ◽  
Deniz Dinçer ◽  
Suna Meral ◽  
Nuray Yildizoğlu-Ari ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Vascular Responsiveness ◽  
Streptozotocin Diabetic Rats

Improvement in cardiac function in streptozotocin-diabetic rats by salt loading

1994 ◽  
Vol 72 (11) ◽  
pp. 1288-1293 ◽  
Author(s):  
Soter Dai ◽  
Heather Fraser ◽  
Violet G. Yuen ◽  
John H. McNeill
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Cardiac Function ◽  
Body Weight Gain ◽  
Myocardial Dysfunction ◽  
Streptozotocin Diabetes ◽  
Diabetic Rats ◽  
Salt Loading ◽  
Glucose Levels ◽  
Streptozotocin Diabetic Rats

Effects of salt loading by drinking 0.9% NaCl solution on the myocardial performance in nondiabetic and diabetic Wistar rats were studied using the isolated working heart apparatus. Body weight and fluid and food intakes of these animals were monitored. Blood pressure and plasma levels of glucose, insulin, cholesterol, and triglycerides were also measured. Diabetes was induced by intravenous injection of streptozotocin (60 mg/kg). Diabetic rats were found to develop myocardial dysfunction at 8 weeks after STZ injection, accompanied by significant increases in food and fluid intakes, slowed body weight gain, hyperglycemia, hypoinsulinemia, and hyperlipidemia but without significant changes in blood pressure. Salt loading did not cause significant changes in any of the parameters studied in nondiabetic rats. However, in streptozotocin-diabetic rats given saline to drink, the impaired myocardial function was significantly improved and was associated with a significant reduction in hyperphagia and hyperlipidemia. Plasma glucose levels significantly decreased at weeks 1–3 but increased to the levels of untreated diabetic animals at weeks 4–7. There was an increase in fluid intake, but neither blood pressure nor plasma insulin levels were significantly affected. It is suggested that the improvements in cardiac function and hyperlipidemia in diabetic rats by salt loading may be related to each other; however, the mechanisms for these effects are not clear but are unlikely to be due to changes in glycemic control.Key words: streptozotocin diabetes, salt loading, cardiac dysfunction.

scholarly journals The effect of vanadyl treatment on vascular responsiveness of streptozotocin-diabetic rats

Diabetologia ◽  
1994 ◽  
Vol 37 (6) ◽  
pp. 572-578 ◽  
Author(s):  
A. T. �z�elikay ◽  
C. Pekiner ◽  
N. Ari ◽  
Y. �zt�rk ◽  
A. �z�ari ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Vascular Responsiveness ◽  
Streptozotocin Diabetic Rats

scholarly journals The effect of vanadyl treatment on vascular responsiveness of streptozotocin-diabetic rats

Diabetologia ◽  
1994 ◽  
Vol 37 (6) ◽  
pp. 572-578 ◽  
Author(s):  
A. T. �z�elikay ◽  
C. Pekiner ◽  
N. Ari ◽  
Y. �zt�rk ◽  
A. �z�ari ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Vascular Responsiveness ◽  
Streptozotocin Diabetic Rats

1109-P: Blood Pressure (BP) Lowering Effect of Empagliflozin Is Related to Decreased L-Arginine Clearance in Diabetic Rats

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1109-P
Author(s):  
SONIA KHEMAIS-BENKHIAT ◽  
DANIEL VEYEL ◽  
VALERIE SCHINI-KERTH ◽  
BARTLOMIEJ KRAWCZYK ◽  
MICHAEL PIEPER ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diabetic Rats ◽  
Lowering Effect
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