The role of hepatitis C virus specific CD4+ T lymphocytes in acute and chronic hepatitis C

1996 ◽  
Vol 74 (10) ◽  
pp. 583-588 ◽  
Author(s):  
H. M. Diepolder ◽  
R. Zachoval ◽  
R. M. Hoffmann ◽  
M.-C. Jung ◽  
T. Gerlach ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Lymphocytes ◽  
Chronic Hepatitis C ◽  
Acute And Chronic Hepatitis

scholarly journals Cytotoxic T Lymphocytes Derived from Patients with Chronic Hepatitis C Virus Infection Kill Bystander Cells via Fas-FasL Interaction

2004 ◽  
Vol 78 (4) ◽  
pp. 2152-2157 ◽  
Author(s):  
Christel Gremion ◽  
Benno Grabscheid ◽  
Benno Wölk ◽  
Darius Moradpour ◽  
Jürg Reichen ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Lymphocytes ◽  
Virus Infection ◽  
Chronic Hepatitis C ◽  
Cytotoxic T Lymphocytes ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus

ABSTRACT The role of Fas-mediated lysis of hepatocytes in hepatitis C virus (HCV)-induced injury is frequently discussed. We therefore analyzed the effect of the number of HCV antigen-expressing cells, the mode of antigen presentation, and the number of cytotoxic T lymphocytes in a coculture system mimicking cellular components of the liver. Here, we show that endogenously processed HCV proteins are capable of inducing bystander killing. We further demonstrate that 0.8 to 1.5% of cells presenting HCV antigens suffice to induce lysis of 10 to 29% of bystander cells, suggesting that the mechanism may be operative at low fractions of infected versus uninfected hepatocytes in vivo. Our data underscore the role of the Fas pathway in HCV-related liver injury and support the exploration of Fas-based treatment strategies for patients with chronic hepatitis C virus infection.

scholarly journals Hemolytic anemia induced by ribavirin therapy in patients with chronic hepatitis C virus infection: Role of membrane oxidative damage

Hepatology ◽  
2000 ◽  
Vol 31 (4) ◽  
pp. 997-1004 ◽  
Author(s):  
Lucia De Franceschi ◽  
Giovanna Fattovich ◽  
Franco Turrini ◽  
Kodjo Ayi ◽  
Carlo Brugnara ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Oxidative Damage ◽  
Chronic Hepatitis C ◽  
Hemolytic Anemia ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus

Role of IL28B and inosine triphosphatase polymorphisms in the treatment of chronic hepatitis C virus genotype 6 infection

2013 ◽  
Vol 20 (7) ◽  
pp. 470-477 ◽  
Author(s):  
W.-K. Seto ◽  
O. T.-Y. Tsang ◽  
K. Liu ◽  
J. M.-C. Chan ◽  
D. K.-H. Wong ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Virus Genotype ◽  
Chronic Hepatitis C Virus ◽  
Inosine Triphosphatase
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