scholarly journals Hemolytic anemia induced by ribavirin therapy in patients with chronic hepatitis C virus infection: Role of membrane oxidative damage

Hepatology ◽  
2000 ◽  
Vol 31 (4) ◽  
pp. 997-1004 ◽  
Author(s):  
Lucia De Franceschi ◽  
Giovanna Fattovich ◽  
Franco Turrini ◽  
Kodjo Ayi ◽  
Carlo Brugnara ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Oxidative Damage ◽  
Chronic Hepatitis C ◽  
Hemolytic Anemia ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus

Specialty Evaluation in Patients With Chronic Hepatitis C Virus Infection—Role of Patient Versus Non-Patient Factors

2011 ◽  
Vol 140 (5) ◽  
pp. S-934
Author(s):  
Fasiha Kanwal ◽  
Tuyen Hoang ◽  
Jennifer R. Kramer ◽  
Timothy Chrusciel ◽  
Steven M. Asch ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Chronic Hepatitis C ◽  
Hepatitis C Virus Infection ◽  
Patient Factors ◽  
Chronic Hepatitis C Virus

scholarly journals Cytotoxic T Lymphocytes Derived from Patients with Chronic Hepatitis C Virus Infection Kill Bystander Cells via Fas-FasL Interaction

2004 ◽  
Vol 78 (4) ◽  
pp. 2152-2157 ◽  
Author(s):  
Christel Gremion ◽  
Benno Grabscheid ◽  
Benno Wölk ◽  
Darius Moradpour ◽  
Jürg Reichen ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Lymphocytes ◽  
Virus Infection ◽  
Chronic Hepatitis C ◽  
Cytotoxic T Lymphocytes ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus

ABSTRACT The role of Fas-mediated lysis of hepatocytes in hepatitis C virus (HCV)-induced injury is frequently discussed. We therefore analyzed the effect of the number of HCV antigen-expressing cells, the mode of antigen presentation, and the number of cytotoxic T lymphocytes in a coculture system mimicking cellular components of the liver. Here, we show that endogenously processed HCV proteins are capable of inducing bystander killing. We further demonstrate that 0.8 to 1.5% of cells presenting HCV antigens suffice to induce lysis of 10 to 29% of bystander cells, suggesting that the mechanism may be operative at low fractions of infected versus uninfected hepatocytes in vivo. Our data underscore the role of the Fas pathway in HCV-related liver injury and support the exploration of Fas-based treatment strategies for patients with chronic hepatitis C virus infection.

scholarly journals Role of chemokines and their receptors in viral persistence and liver damage during chronic hepatitis C virus infection

2008 ◽  
Vol 14 (47) ◽  
pp. 7149 ◽  
Author(s):  
Juan R Larrubia ◽  
Selma Benito-Martínez ◽  
Miryam Calvino ◽  
Eduardo Sanz-de-Villalobos ◽  
Trinidad Parra-Cid
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Chronic Hepatitis C ◽  
Liver Damage ◽  
Viral Persistence ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus
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