Elevated p21 mRNA level in skeletal muscle of DMD patients and mdx mice indicates either an exhausted satellite cell pool or a higher p21 expression in dystrophin-deficient cells per se

2000 ◽  
Vol 78 (10) ◽  
pp. 569-574 ◽  
Author(s):  
Stefanie Endesfelder ◽  
Antje Krahn ◽  
Karl-Anton Kreuzer ◽  
Ulrich Lass ◽  
Christian Andreas Schmidt ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Satellite Cell ◽  
Mrna Level ◽  
Mdx Mice ◽  
Cell Pool ◽  
Per Se

scholarly journals Satellite-cell pool size does matter: Defining the myogenic potency of aging skeletal muscle

2006 ◽  
Vol 294 (1) ◽  
pp. 50-66 ◽  
Author(s):  
Gabi Shefer ◽  
Daniel P. Van de Mark ◽  
Joshua B. Richardson ◽  
Zipora Yablonka-Reuveni
Keyword(s):  
Skeletal Muscle ◽  
Satellite Cell ◽  
Pool Size ◽  
Cell Pool

scholarly journals Satellite cell pool size expansion is affected by skeletal muscle characteristics

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Filippo Macaluso ◽  
Naomi E Brooks ◽  
Carola U Niesler ◽  
Kathy H Myburgh
Keyword(s):  
Skeletal Muscle ◽  
Satellite Cell ◽  
Pool Size ◽  
Cell Pool

scholarly journals Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice

PLoS Genetics ◽  
2019 ◽  
Vol 15 (10) ◽  
pp. e1008408 ◽  
Author(s):  
Luca Madaro ◽  
Alessio Torcinaro ◽  
Marco De Bardi ◽  
Federica F. Contino ◽  
Mattia Pelizzola ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cell Fate ◽  
Satellite Cell ◽  
Mdx Mice ◽  
Fine Tune

scholarly journals Influence of sex and fiber type on the satellite cell pool in human skeletal muscle

2020 ◽  
Author(s):  
Oscar Horwath ◽  
Marcus Moberg ◽  
Filip J. Larsen ◽  
Andrew Philp ◽  
William Apró ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Satellite Cell ◽  
Human Skeletal Muscle ◽  
Fiber Type ◽  
Cell Pool

scholarly journals Muscle satellite cells adopt divergent fates

2004 ◽  
Vol 166 (3) ◽  
pp. 347-357 ◽  
Author(s):  
Peter S. Zammit ◽  
Jon P. Golding ◽  
Yosuke Nagata ◽  
Valérie Hudon ◽  
Terence A. Partridge ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Satellite Cell ◽  
Satellite Cells ◽  
Muscle Regeneration ◽  
Cell Phenotype ◽  
Proliferating Cells ◽  
Cell Compartment ◽  
Adult Skeletal Muscle ◽  
Muscle Stem Cells ◽  
Cell Pool

Growth, repair, and regeneration of adult skeletal muscle depends on the persistence of satellite cells: muscle stem cells resident beneath the basal lamina that surrounds each myofiber. However, how the satellite cell compartment is maintained is unclear. Here, we use cultured myofibers to model muscle regeneration and show that satellite cells adopt divergent fates. Quiescent satellite cells are synchronously activated to coexpress the transcription factors Pax7 and MyoD. Most then proliferate, down-regulate Pax7, and differentiate. In contrast, other proliferating cells maintain Pax7 but lose MyoD and withdraw from immediate differentiation. These cells are typically located in clusters, together with Pax7−ve progeny destined for differentiation. Some of the Pax7+ve/MyoD−ve cells then leave the cell cycle, thus regaining the quiescent satellite cell phenotype. Significantly, noncycling cells contained within a cluster can be stimulated to proliferate again. These observations suggest that satellite cells either differentiate or switch from terminal myogenesis to maintain the satellite cell pool.

scholarly journals Expression of the glucose transporter GLUT4 in the muscular dystrophic mdx mouse

1993 ◽  
Vol 291 (1) ◽  
pp. 257-261 ◽  
Author(s):  
C Olichon-Berthe ◽  
N Gautier ◽  
E Van Obberghen ◽  
Y Le Marchand-Brustel
Keyword(s):  
Skeletal Muscle ◽  
Plasma Membranes ◽  
Glucose Transporter ◽  
Mrna Level ◽  
Mdx Mouse ◽  
Mdx Mice ◽  
Mrna Levels ◽  
Skeletal Tissue ◽  
Muscle Tissues ◽  
And Control

Glucose transporter protein levels have been investigated in mdx and control (C57Bl/10) mice. Crude membrane fractions (microsomes plus plasma membranes) were prepared from skeletal muscle, heart, diaphragm and brain of 5-6-week-old and 6-7-month-old control and mdx mice. Using Western blot analysis with C-terminal-specific anti-peptide antibodies, we investigated the glucose transporters GLUT4 in the different muscle tissues and GLUT1 in brain. In skeletal tissue from the hindlegs, GLUT4 was increased by approximately 55% in mdx mice compared with control mice at both ages studied. In the diaphragm, the amount of GLUT4 protein was unchanged in young mdx mice, and was decreased by 37.4 +/- 4.7% in older mice compared with age-matched control mice. No difference was observed between mdx and control mice in the amounts of GLUT4 and GLUT1 in heart and brain preparations respectively. To determine whether the change in GLUT4 protein observed in the diaphragm and skeletal muscle of mdx mice was regulated through changes at the level of glucose transporter mRNA, Northern blot analyses were performed. In skeletal muscle, GLUT4 mRNA level per tissue was not different between the two groups of mice at both ages studied. In contrast, the decrease in the amount of GLUT4 protein observed in the diaphragm of 6-7-month-old mdx mice was accompanied by a decrease in the GLUT4 mRNA level. In conclusion, the levels of GLUT4 protein were modified in muscle tissues from mdx compared with control mice, and these modifications were different depending on the muscle involved and the age of the mice. An increase in the amount of GLUT4 protein in the skeletal muscle of mdx mice was not due to changes at the mRNA level. The diaphragms of 6-7-month-old mdx mice exhibited decreases in GLUT4 protein and mRNA levels that were not detected in young animals (5-6 weeks old).

Satellite cell pool expansion is affected by skeletal muscle characteristics

2013 ◽  
Vol 48 (1) ◽  
pp. 109-116 ◽  
Author(s):  
Filippo Macaluso ◽  
Naomi E. Brooks ◽  
Carola U. Niesler ◽  
Kathryn H. Myburgh
Keyword(s):  
Skeletal Muscle ◽  
Satellite Cell ◽  
Cell Pool

scholarly journals Angiotensin II depletes the skeletal muscle satellite cell pool and prevents skeletal muscle regeneration

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Tadashi Yoshida ◽  
Sarah Galvez ◽  
Bashir M. Rezk ◽  
Laura Semprun-Prieto ◽  
Sergiy Sukhanov ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Angiotensin Ii ◽  
Satellite Cell ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration ◽  
Muscle Satellite Cell ◽  
Cell Pool ◽  
Skeletal Muscle Satellite Cell
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