The water-soluble components of the essential oil of Melaleuca alternifolia (tea tree oil) suppress the production of superoxide by human monocytes, but not neutrophils, activated in vitro

2001 ◽  
Vol 50 (4) ◽  
pp. 213-219 ◽  
Author(s):  
C. Brand ◽  
A. Ferrante ◽  
R.H. Prager ◽  
T.V. Riley ◽  
C.F. Carson ◽  
...  
Keyword(s):  
Essential Oil ◽  
Water Soluble ◽  
Human Monocytes ◽  
Tea Tree Oil ◽  
Melaleuca Alternifolia ◽  
Tea Tree ◽  
Soluble Components

scholarly journals The application of tea tree essential oil in dentistry

2007 ◽  
Vol 54 (2) ◽  
pp. 106-114
Author(s):  
D. Markovic ◽  
B. Mirkovic ◽  
T. Jovanovic ◽  
A. Knezevic ◽  
T. Nastovski
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Fusobacterium Nucleatum ◽  
Viral Diseases ◽  
Prevotella Intermedia ◽  
Tea Tree Oil ◽  
Melaleuca Alternifolia ◽  
Tea Tree ◽  
Plant Substances

Essential oils are widely used in medicine, dentistry and cosmetology as flavour and odour corrigents in various substances for oral hygiene. The aim of this study was to present comprehensively the possibilities for application of Melaleuca Alternifolia essential oil in dentistry based on the analysis of contemporary scientific and professional publications. The application of Tea tree essential oil in the treatment of periodontal, fungal and viral diseases is very efficient. The study of antimicrobial potential of ten different essential oils confirmed the efficiency of Tea tree oil against numerous Gram+ and Gram- bacteria. In vitro studies of bacteriostatic, bactericidal and fungicidal effect of Tea tree oil solution against ten different microorganisms confirmed sensitivity of the following microorganisms: Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum and Porphyromonas gingivalis, and slightly weaker effect against Streptococcus Mutans and Prevotella intermedia. Tea tree is very effective in the treatment of various diseases and is an introduction and momentum for the application of plant substances in the treatment of numerous diseases in dentistry. .

scholarly journals Activity of Tea Tree (Melaleuca alternifolia) Essential Oil against L3 Larvae ofAnisakis simplex

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Carlota Gómez-Rincón ◽  
Elisa Langa ◽  
Paula Murillo ◽  
Marta Sofía Valero ◽  
César Berzosa ◽  
...  
Keyword(s):  
Essential Oil ◽  
Therapeutic Potential ◽  
Anisakis Simplex ◽  
Ache Inhibitor ◽  
Tea Tree Oil ◽  
Melaleuca Alternifolia ◽  
Tea Tree ◽  
Dependent Inhibition ◽  
Ld50 Value

Nematicidal activity ofMelaleuca alternifoliaessential oil, commonly known as tea tree oil (TTO), was assayedin vitroagainst L3 larvae ofAnisakis simplex. The results showed a mortality of 100% for concentrations between 7 and 10 μL/mL after 48 h of incubation, obtaining an LD50 value of 4.53 μL/mL after 24 hours and 4.27 μL/mL after 48 hours. Concentration-dependent inhibition of acetylcholinesterase was observed for tea tree essential oil showing inhibition values of 100% at 100 μL/mL. This fact suggests that TTO may act as an AChE inhibitor. Terpinen-4-ol was discarded as main larvicide compound as it did not show larvicidal or anticholinesterase activity. The data obtained suggest that the essential oil ofMelaleuca alternifoliamay have a great therapeutic potential for the treatment of human anisakiasis.

scholarly journals Emprego do óleo de Melaleuca alternifolia Cheel (Myrtaceae) na odontologia: perspectivas quanto à utilização como antimicrobiano alternativo às doenças infecciosas de origem bucal

2011 ◽  
Vol 13 (4) ◽  
pp. 492-499 ◽  
Author(s):  
A.C.M. Oliveira ◽  
A. Fontana ◽  
T.C. Negrini ◽  
M.N.M. Nogueira ◽  
T.B.L. Bedran ◽  
...  
Keyword(s):  
Tea Tree Oil ◽  
Melaleuca Alternifolia ◽  
Tea Tree

O interesse por medicamentos alternativos, principalmente daqueles provenientes de extratos naturais, tem aumentado nas últimas décadas. A Melaleuca alternifolia é um arbusto pertencente ao gênero Melaleuca, popularmente conhecida como "árvore de chá", cujo principal produto é o óleo essencial (TTO - tea tree oil), de grande importância medicinal por possuir comprovada ação bactericida e antifúngica contra diversos patógenos humanos. Em virtude da atividade terapêutica em diversas especialidades médicas, o TTO passou a ser empregado na área odontológica. Esta revisão de literatura foi realizada com o objetivo de discutir os ensaios já realizados com o TTO contra microrganismos relacionados à doença cárie, doença periodontal e problemas pulpares. O óleo de Melaleuca tem demonstrado boa ação antibacteriana in vitro contra microrganismos bucais, porém, pesquisas envolvendo o estudo do mecanismo de ação sobre as células microbianas ou estudos in vivo ainda são escassos e precisam ser realizados, já que esse produto pode ser útil na odontologia, seja na manutenção química da higiene ou prevenção de doenças bucais.

Melaleuca alternifolia Essential Oil: Evaluation of Skin Permeation and Distribution from Topical Formulations with a Solvent-Free Analytical Method

Planta Medica ◽  
2020 ◽  
Vol 86 (06) ◽  
pp. 442-450
Author(s):  
Francesca Capetti ◽  
Barbara Sgorbini ◽  
Cecilia Cagliero ◽  
Monica Argenziano ◽  
Roberta Cavalli ◽  
...  
Keyword(s):  
Essential Oil ◽  
Solid Phase ◽  
Biological Activities ◽  
Skin Permeation ◽  
Systemic Exposure ◽  
Solvent Free ◽  
Tea Tree Oil ◽  
Melaleuca Alternifolia ◽  
Topical Formulations ◽  
Tea Tree

Abstract Melaleuca alternifolia essential oil (tea tree oil) is widely used as an ingredient in skin care products because of its recognized biological activities. The European Scientific Committee on Consumer Products constantly promotes research and collection of data on both skin distribution and systemic exposure to tea tree oil components after the application of topical formulations. This study quantitatively evaluates permeation, skin layer distribution (stratum corneum, epidermis, and dermis), and release into the surrounding environment of bioactive tea tree oil markers (i.e., α-pinene, β-pinene, α-terpinene, 1,8-cineole, γ-terpinene, 4-terpineol, α-terpineol) when a 5% tea tree oil formulation is applied at a finite dosing regimen. Permeation kinetics were studied in vitro on pig ear skin using conventional static glass Franz diffusion cells and cells ad hoc modified to monitor the release of markers into the atmosphere. Formulation, receiving phases, and skin layers were analyzed using a fully automatic and solvent-free method based on headspace solid-phase microextraction/gas chromatography-mass spectrometry. This approach affords, for the first time, to quantify tea tree oil markers in the different skin layers while avoiding using solvents and overcoming the existing methods based on solvent extraction. The skin layers contained less than 1% of each tea tree oil marker in total. Only oxygenated terpenes significantly permeated across the skin, while hydrocarbons were only absorbed at trace level. Substantial amounts of markers were released into the atmosphere.

scholarly journals Effects of Melaleuca alternifolia (Tea Tree) Essential Oil and the Major Monoterpene Component Terpinen-4-ol on the Development of Single- and Multistep Antibiotic Resistance and Antimicrobial Susceptibility

2011 ◽  
Vol 56 (2) ◽  
pp. 909-915 ◽  
Author(s):  
Katherine A. Hammer ◽  
Christine F. Carson ◽  
Thomas V. Riley
Keyword(s):  
Antibiotic Resistance ◽  
Essential Oil ◽  
Antimicrobial Susceptibility ◽  
Single Step ◽  
Tea Tree Oil ◽  
Melaleuca Alternifolia ◽  
Antibiotic Resistant ◽  
Content Type ◽  
Tea Tree ◽  
E Coli

ABSTRACTThis study examined the effect of subinhibitoryMelaleuca alternifolia(tea tree) essential oil on the development of antibiotic resistance inStaphylococcus aureusandEscherichia coli. Frequencies of single-step antibiotic-resistant mutants were determined by inoculating bacteria cultured with or without subinhibitory tea tree oil onto agar containing 2 to 8 times the MIC of each antibiotic and with or without tea tree oil. Whereas most differences in resistance frequencies were relatively minor, the combination of kanamycin and tea tree oil yielded approximately 10-fold fewer resistantE. colimutants than kanamycin alone. The development of multistep antibiotic resistance in the presence of tea tree oil or terpinen-4-ol was examined by culturingS. aureusandE. coliisolates daily with antibiotic alone, antibiotic with tea tree oil, and antibiotic with terpinen-4-ol for 6 days. Median MICs for each antibiotic alone increased 4- to 16-fold by day 6. Subinhibitory tea tree oil or terpinen-4-ol did not greatly alter results, with day 6 median MICs being either the same as or one concentration different from those for antibiotic alone. For tea tree oil and terpinen-4-ol alone, day 6 median MICs had increased 4-fold forS. aureus(n= 18) and 2-fold forE. coli(n= 18) from baseline values. Lastly, few significant changes in antimicrobial susceptibility were seen forS. aureusandS. epidermidisisolates that had been serially subcultured 14 to 22 times with subinhibitory terpinen-4-ol. Overall, these data indicate that tea tree oil and terpinen-4-ol have little impact on the development of antimicrobial resistance and susceptibility.

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