Amelioration of rat adjuvant arthritis by therapeutic treatment with bindarit, an inhibitor of MCP-1 and TNF-α production

2002 ◽  
Vol 51 (5) ◽  
pp. 252-258 ◽  
Author(s):  
A. Guglielmotti ◽  
E. D'Onofrio ◽  
I. Coletta ◽  
L. Aquilini ◽  
C. Milanese ◽  
...  
Keyword(s):  
Adjuvant Arthritis ◽  
Therapeutic Treatment ◽  
Tnf Α ◽  
Rat Adjuvant Arthritis

scholarly journals Potential role of heme oxygenase-1 in the progression of rat adjuvant arthritis

2004 ◽  
Vol 85 (1) ◽  
pp. 34-44 ◽  
Author(s):  
Isabel Devesa ◽  
Maria Luisa Ferrándiz ◽  
Isabel Guillén ◽  
José Miguel Cerdá ◽  
Maria José Alcaraz
Keyword(s):  
Heme Oxygenase ◽  
Adjuvant Arthritis ◽  
Potential Role ◽  
Heme Oxygenase 1 ◽  
Rat Adjuvant Arthritis

Local metabolism of glucocorticoids and its role in rat adjuvant arthritis

2010 ◽  
Vol 323 (2) ◽  
pp. 155-160 ◽  
Author(s):  
Peter Ergang ◽  
Pavel Leden ◽  
Karla Vagnerová ◽  
Petra Klusoňová ◽  
Ivan Mikšík ◽  
...  
Keyword(s):  
Adjuvant Arthritis ◽  
Rat Adjuvant Arthritis ◽  
Local Metabolism

Immunohistochemical study of the proliferation modality of synoviumin rat adjuvant arthritis

2003 ◽  
Vol 8 (3) ◽  
pp. 400-407 ◽  
Author(s):  
Munetada Kamimoto ◽  
Motoshi Kikuchi ◽  
Takashi Yashiro ◽  
Aki Nihei ◽  
Yusei Kariya ◽  
...  
Keyword(s):  
Adjuvant Arthritis ◽  
Immunohistochemical Study ◽  
Rat Adjuvant Arthritis

Capsaicin effects on substance P and CGRP in rat adjuvant arthritis

1995 ◽  
Vol 55 (1) ◽  
pp. 85-102 ◽  
Author(s):  
Mahmood Ahmed ◽  
Anders Bjurholm ◽  
Gopala Rao Srinivasan ◽  
Tomas Lundeberg ◽  
Elvar Theodorsson ◽  
...  
Keyword(s):  
Substance P ◽  
Adjuvant Arthritis ◽  
Rat Adjuvant Arthritis

scholarly journals Kinetics and Interplay of Mediators of Inflammation-Induced Bone Damage in the Course of Adjuvant Arthritis

2013 ◽  
Vol 26 (1) ◽  
pp. 37-48 ◽  
Author(s):  
S.M. Nanjundaiah ◽  
J.P. Stains ◽  
K.D. Moudgil
Keyword(s):  
Bone Remodeling ◽  
Inflammatory Cytokines ◽  
Adjuvant Arthritis ◽  
Bone Erosion ◽  
Experimental Conditions ◽  
Mediators Of Inflammation ◽  
Bone Damage ◽  
Tnf Α ◽  
Kinetics Of ◽  
Pro Inflammatory Cytokines

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation, bone erosion, and cartilage destruction in the joints. It is increasingly being realized that inflammation might play an important role in inducing bone damage in arthritis. However, there is limited validation of this concept in vivo in well-controlled experimental conditions. We addressed this issue using the adjuvant arthritis (AA) model of RA. In AA, the draining lymph nodes are the main sites of activation of pathogenic leukocytes, which then migrate into the joints leading to the induction of arthritis. We tested the temporal kinetics of mediators of bone damage [e.g., receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG) and osteopontin (OPN)] and inflammation (pro-inflammatory cytokines and chemokines) in the draining lymph node cells (LNC) at different phases of AA, and then examined their inter-relationships. Our study revealed that, together with cytokines/chemokines, some of the mediators of bone remodeling are also produced in LNC. Various cytokines/chemokines showed distinct kinetics of expression as well as patterns of correlation with mediators of bone remodeling at different phases of the disease. Pro-inflammatory cytokines such as TNF-α are known to play an important role in bone damage. Interestingly, there was a positive correlation between TNF-α and RANKL, between RANKL and each of the 3 chemokines tested (RANTES, MIP-1α, and GRO/KC), and between TNF-α and RANTES. Our results in the AA model lend support to the concept of osteo-immune crosstalk during the course of autoimmune arthritis.

Anti-arthritic effects demonstrated by an interleukin-2 receptor-targeted cytotoxin (DAB486IL-2) in rat adjuvant arthritis

1992 ◽  
Vol 22 (7) ◽  
pp. 1673-1679 ◽  
Author(s):  
Patricia Bacha ◽  
Serene E. Forte ◽  
Stuart J. Perper ◽  
David E. Trentham ◽  
Jean C. Nichols
Keyword(s):  
Adjuvant Arthritis ◽  
Interleukin 2 ◽  
Interleukin 2 Receptor ◽  
Rat Adjuvant Arthritis

scholarly journals Modulation of methotrexate efficacy by green tea polyphenols in rat adjuvant arthritis

2020 ◽  
Vol 14 ◽  
pp. 100228
Author(s):  
Silvester Ponist ◽  
Concetta Gardi ◽  
Ludmila Paskova ◽  
Karol Svik ◽  
Lukas Slovak ◽  
...  
Keyword(s):  
Green Tea ◽  
Adjuvant Arthritis ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Rat Adjuvant Arthritis

scholarly journals Exacerbation of rat adjuvant arthritis by intradermal injection of purified mammalian 14-kDa group II phospholipase A2

FEBS Letters ◽  
1990 ◽  
Vol 268 (1) ◽  
pp. 113-116 ◽  
Author(s):  
Makoto Murakami ◽  
Ichiro Kudo ◽  
Hideo Nakamura ◽  
Yuichi Yokoyama ◽  
Hiroshi Mori ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Adjuvant Arthritis ◽  
Intradermal Injection ◽  
Rat Adjuvant Arthritis ◽  
Group Ii
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