Partial phase behavior of ionic microemulsions stabilized by sodium dodecylsulfate and alcohol cosurfactants

Equilibrium vesicles, those which are the stable form of aggregation and form spontaneously on mixing surfactant with water, have never been demonstrated in single component bilayers and only rarely in lipid or surfactant mixtures. Designing a simple and general method for producing spontaneous and stable vesicles depends on a better understanding of the thermodynamics of aggregation, the interplay of intermolecular forces in surfactants, and an efficient way of doing structural characterization in dynamic systems.

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Effect of the Structures of Ionic Liquids on Their Physical-Chemical Properties and the Phase Behavior of Mixtures Involving Ionic Liquids

Chemical Reviews ◽

10.1021/cr0502044 ◽

2006 ◽

Vol 0 (0) ◽

pp. 0-0 ◽

Cited By ~ 4

Author(s):

Y.-F. Hu ◽

C.-M. Xu

Keyword(s):

Ionic Liquids ◽

Phase Behavior ◽

Chemical Properties ◽

Physical Chemical

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Solution Properties and Phase Behavior of Ammonium Hexylene Octyl Succinate in Water and Water-Oil System

Dhaka University Journal of Pharmaceutical Sciences ◽

10.3329/dujps.v3i1.183 ◽

1970 ◽

Vol 3 (1) ◽

Author(s):

Md. Hamidul Kabir ◽

Ravshan Makhkamov ◽

Shaila Kabir

Keyword(s):

Critical Micelle Concentration ◽

Phase Behavior ◽

Liquid Crystalline ◽

Carbon Number ◽

Phase Region ◽

Solution Properties ◽

Middle Phase ◽

Two Phase ◽

Lamellar Liquid Crystal ◽

Drug Ingredient

The solution properties and phase behavior of ammonium hexylene octyl succinate (HOS) was investigated in water and water-oil system. The critical micelle concentration (CMC) of HOS is lower than that of anionic surfactants having same carbon number in the lipophilic part. The phase diagrams of a water/ HOS system and water/ HOS/ C10EO8/ dodecane system were also constructed. Above critical micelle concentration, the surfactant forms a normal micellar solution (Wm) at a low surfactant concentration whereas a lamellar liquid crystalline phase (La) dominates over a wide region through the formation of a two-phase region (La+W) in the binary system. The lamellar phase is arranged in the form of a biocompatible vesicle which is very significant for the drug delivery system. The surfactant tends to be hydrophilic when it is mixed with C10EO8 and a middle-phase microemulsion (D) is appeared in the water-surfactant-dodecane system where both the water and oil soluble drug ingredient can be incorporated in the form of a dispersion. Hence, mixing can tune the hydrophile-lipophile properties of the surfactant. Key words: Ammonium hexylene octyl succinate, mixed surfactant, lamellar liquid crystal, middle-phase microemulsion. Dhaka Univ. J. Pharm. Sci. Vol.3(1-2) 2004 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

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