The relationship between structure and biological activity: Some fundamental aspects

2007 ◽  
pp. 425-461
Author(s):  
Adrien Albert
Keyword(s):  
Biological Activity ◽  
The Relationship

scholarly journals Synthesis, Characterization & Antimicrobial Activities of New Isoxazole Substituted Mannich and Schiff Bases of 5-Nitroisatin Analogs

2020 ◽  
Vol 32 (4) ◽  
pp. 970-974
Author(s):  
Ch. Jithendra ◽  
G. Saravanan ◽  
V. Alagarsamy ◽  
T. Panneerselvam ◽  
K. Selvaraj ◽  
...  
Keyword(s):  
Biological Activity ◽  
Functional Group ◽  
Mannich Base ◽  
Antimicrobial Activities ◽  
Mannich Bases ◽  
Pathogenic Microorganism ◽  
Diffusion Technique ◽  
Group Variation ◽  
The Relationship ◽  
Isoxazole Derivatives

A sequence of new isoxazole substituted Schiff base and Mannich base of 5-nitroisatin are synthesized by a multi-step synthesis from 5-nitroisatin. Whole synthesized analogs were characterized using IR, NMR, Mass spectroscopy and microanalyses. All the Schiff and Mannich bases were tested for their antimicrobial potencies against some human pathogenic microorganism using agar well diffusion technique. The relationship between the biological activity and the functional group variation of the Schiff and Mannich bases were analyzed. Standard ciprofloxacin and ketoconazole were used to compare the antimicrobial activities of novel isatin coupled isoxazole derivatives.

Synthesis, Study of the Biological Activity of New 1,2,4‐Triazole Derivatives and Characteristics of the Relationship of the Structure and Biological Activity in a Series of the Latter

2019 ◽  
Vol 4 (42) ◽  
pp. 12386-12390
Author(s):  
Armen S. Galstyan ◽  
Tariel V. Ghochikyan ◽  
Melanya A. Samvelyan ◽  
Vardges R. Frangyan ◽  
Muhammad Sarfraz
Keyword(s):  
Biological Activity ◽  
Triazole Derivatives ◽  
Relationship Of ◽  
The Relationship

The relationship between the electrospray ionization behaviour and biological activity of some phosphino Cu(I) complexes

2010 ◽  
Vol 24 (11) ◽  
pp. 1610-1616 ◽  
Author(s):  
Francesco Tisato ◽  
Fiorenzo Refosco ◽  
Marina Porchia ◽  
Matteo Tegoni ◽  
Valentina Gandin ◽  
...  
Keyword(s):  
Biological Activity ◽  
Electrospray Ionization ◽  
The Relationship

Synthesis and Biological Activities of Sulfonated Polysaccharides Having Pentofuransidic Structures

2007 ◽  
Vol 342-343 ◽  
pp. 721-724
Author(s):  
Byung Won Kang ◽  
T. Yoshida ◽  
Jong Baek Lee ◽  
S.J. Jeon ◽  
H.D. Choi
Keyword(s):  
Biological Activity ◽  
Biological Activities ◽  
Anticoagulant Activity ◽  
Polymer Backbone ◽  
Molecular Weights ◽  
The Relationship ◽  
Anti Hiv

In order to elucidate the relationship between the structure and biological activity such as anti-HIV and blood anticoagulant activity, sulfonated polysaccharides and amino-polysaccharides having pentofuranosidic structures were synthesized. These sulfonated polysaccharides had potent anti-HIV activity in spite of low molecular weights, and which was dependent on the degree of sulfonation. For the blood anticoagulant activity, the conformation of polymer backbone and sulfamide group plays an important role on the interactions with the blood anticoagulant factor.

Protein analysis as a measure of active biomass in activated sludge

2012 ◽  
Vol 65 (8) ◽  
pp. 1483-1489 ◽  
Author(s):  
E. Yücesoy ◽  
N. Lüdemann ◽  
H. Lucas ◽  
J. Tan ◽  
M. Denecke
Keyword(s):  
Biological Activity ◽  
Activated Sludge ◽  
Protein Content ◽  
Suspended Solids ◽  
Oxygen Uptake Rate ◽  
Biomass Concentration ◽  
Active Biomass ◽  
Lowry Method ◽  
Conventional Methods ◽  
The Relationship

Conventional methods to determine the biomass in activated sludge are the measurement of total suspended solids (TSS) and volatile suspended solids (VSS). Such methods do not distinguish between active biomass and inactive organic material. In this study, biomass was determined with both conventional methods and also through measuring the protein content with the modified Lowry method. In order to investigate the relationship between activity and biomass concentration in terms of TSS, VSS and protein content, some starvation experiments were conducted. It was found that the protein fraction of VSS differs under different starvation conditions. The biological activity of the activated sludge was measured as oxygen uptake rate (OUR). The strongest correlation could be measured between protein and OUR under various conditions. The results show that protein is an appropriate parameter for the measurement of the biological activity.

scholarly journals Monoclonal Antibody Approach to the Relationship between Immunological Structure and Biological Activity of Thyrotropin

1988 ◽  
Vol 2 (7) ◽  
pp. 613-618 ◽  
Author(s):  
Sabine Costagliola ◽  
Anne-Marie Madec ◽  
Moufid M. Benkirane ◽  
Jacques Orgiazzi ◽  
Pierre Carayon
Keyword(s):  
Monoclonal Antibody ◽  
Biological Activity ◽  
The Relationship
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