Effect of age on thymic development, T cell immunity, and helper T cell function

2005 ◽  
pp. 123-139 ◽  
Author(s):  
S. S. Shen ◽  
J. S. Kim ◽  
M. E. Weksler
Keyword(s):  
T Cell ◽  
Cell Function ◽  
T Cell Immunity ◽  
Helper T Cell ◽  
Thymic Development ◽  
T Cell Function ◽  
Cell Immunity ◽  
Effect Of Age

scholarly journals Serine Phosphorylation of SLP76 Is Dispensable for T Cell Development but Modulates Helper T Cell Function

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0170396 ◽  
Author(s):  
Victor H. Navas ◽  
Céline Cuche ◽  
Andres Alcover ◽  
Vincenzo Di Bartolo
Keyword(s):  
T Cell ◽  
Cell Function ◽  
T Cell Development ◽  
Cell Development ◽  
Serine Phosphorylation ◽  
Helper T Cell ◽  
T Cell Function

Altered antibody production and helper T cell function in mice lacking chemokines CCL19 and CCL21-Ser

2010 ◽  
Vol 54 (11) ◽  
pp. 691-701 ◽  
Author(s):  
Kentaro Aritomi ◽  
Taku Kuwabara ◽  
Yuriko Tanaka ◽  
Hideki Nakano ◽  
Takuwa Yasuda ◽  
...  
Keyword(s):  
T Cell ◽  
Antibody Production ◽  
Cell Function ◽  
Helper T Cell ◽  
T Cell Function

scholarly journals Regulation of type 17 helper T-cell function by nitric oxide during inflammation

2011 ◽  
Vol 108 (22) ◽  
pp. 9220-9225 ◽  
Author(s):  
W. Niedbala ◽  
J. C. Alves-Filho ◽  
S. Y. Fukada ◽  
S. M. Vieira ◽  
A. Mitani ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
T Cell ◽  
Cell Function ◽  
Helper T Cell ◽  
T Cell Function

Dysregulated Tim-3 expression and its correlation with imbalanced CD4 helper T cell function in ulcerative colitis

2012 ◽  
Vol 145 (3) ◽  
pp. 230-240 ◽  
Author(s):  
Fengmin Shi ◽  
Xiaoqin Guo ◽  
Xingwei Jiang ◽  
Ping Zhou ◽  
Yan Xiao ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
T Cell ◽  
Cell Function ◽  
Helper T Cell ◽  
T Cell Function

scholarly journals Ligand recognition during thymic development and γδ T cell function specification

2010 ◽  
Vol 22 (4) ◽  
pp. 207-213 ◽  
Author(s):  
Christina Meyer ◽  
Xun Zeng ◽  
Yueh-hsiu Chien
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Ligand Recognition ◽  
Γδ T Cell ◽  
Thymic Development ◽  
T Cell Function

Expression level of costimulatory receptor ICOS is critical for determining the polarization of helper T cell function

2006 ◽  
Vol 15 (4) ◽  
pp. 255-263 ◽  
Author(s):  
Shiho Watanabe ◽  
Shuhei Ogawa ◽  
Yasushi Hara ◽  
Kazunari Tanabe ◽  
Hiroshi Toma ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Function ◽  
Expression Level ◽  
Helper T Cell ◽  
Costimulatory Receptor ◽  
T Cell Function

scholarly journals Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

2001 ◽  
Vol 193 (2) ◽  
pp. 233-238 ◽  
Author(s):  
Madhav V. Dhodapkar ◽  
Ralph M. Steinman ◽  
Joseph Krasovsky ◽  
Christian Munz ◽  
Nina Bhardwaj
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Cell Function ◽  
Cd8 T Cell ◽  
Specific Inhibition ◽  
Killer Activity ◽  
Effector T Cell ◽  
T Cell Function ◽  
Cell Immunity

Immunostimulatory properties of dendritic cells (DCs) are linked to their maturation state. Injection of mature DCs rapidly enhances antigen-specific CD4+ and CD8+ T cell immunity in humans. Here we describe the immune response to a single injection of immature DCs pulsed with influenza matrix peptide (MP) and keyhole limpet hemocyanin (KLH) in two healthy subjects. In contrast to prior findings using mature DCs, injection of immature DCs in both subjects led to the specific inhibition of MP-specific CD8+ T cell effector function in freshly isolated T cells and the appearance of MP-specific interleukin 10–producing cells. When pre- and postimmunization T cells were boosted in culture, there were greater numbers of MP-specific major histocompatibility complex tetramer-binding cells after immunization, but these had reduced interferon γ production and lacked killer activity. These data demonstrate the feasibility of antigen-specific inhibition of effector T cell function in vivo in humans and urge caution with the use of immature DCs when trying to enhance tumor or microbial immunity.

scholarly journals Targeting of Cdc42 GTPase in regulatory T cells unleashes anti-tumor T cell immunity

2021 ◽  
Author(s):  
Khalid W Kalim ◽  
Jun-Qi Yang ◽  
Mark Wunderlich ◽  
Vishnu Modur ◽  
Phuong Nguyen ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Treg Cell ◽  
Cell Function ◽  
Treg Cells ◽  
T Cell Response ◽  
T Cell Immunity ◽  
Cell Plasticity ◽  
Effector T Cell ◽  
Cell Immunity

Regulatory T (Treg) cells play an important role in maintaining immune tolerance through inhibiting effector T cell function. In the tumor microenvironment, Treg cells are utilized by tumor cells to counteract effector T cell-mediated tumor killing. Targeting Treg cells may thus unleash the anti-tumor activity of effector T cells. While systemic depletion of Treg cells can cause excessive effector T cell responses and subsequent autoimmune diseases, controlled targeting of Treg cells may benefit cancer patients. Here we show that Treg cell-specific heterozygous deletion or pharmacological targeting of Cdc42 GTPase does not affect Treg cell numbers but induces Treg cell plasticity, leading to anti-tumor T cell immunity without detectable autoimmune reactions. Cdc42 targeting potentiates an immune checkpoint blocker anti-PD-1 antibody-mediated T cell response against mouse and human tumors. Mechanistically, Cdc42 targeting induces Treg cell plasticity and unleashes anti-tumor T cell immunity through carbonic anhydrase I-mediated pH changes. Thus, rational targeting of Cdc42 in Treg cells holds therapeutic promises in cancer immunotherapy.

scholarly journals Unbalanced helper T cell function in Behcet's disease

2011 ◽  
Vol 31 (3) ◽  
pp. 296-301 ◽  
Author(s):  
Jun Shimizu ◽  
Hideshi Yoshikawa ◽  
Erika Takada ◽  
Chieko Hirotsu ◽  
Noboru Suzuki
Keyword(s):  
T Cell ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Cell Function ◽  
Behçet's Disease ◽  
Helper T Cell ◽  
Behcet's Disease ◽  
T Cell Function
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