scholarly journals Unbalanced helper T cell function in Behcet's disease

2011 ◽  
Vol 31 (3) ◽  
pp. 296-301 ◽  
Author(s):  
Jun Shimizu ◽  
Hideshi Yoshikawa ◽  
Erika Takada ◽  
Chieko Hirotsu ◽  
Noboru Suzuki
1997 ◽  
Vol 15 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Mitsuru Mochizuki ◽  
Eishin Morita ◽  
Shoso Yamamoto ◽  
Seizo Yamana

1994 ◽  
Vol 78 (12) ◽  
pp. 927-932 ◽  
Author(s):  
J H Yamamoto ◽  
Y Fujino ◽  
C Lin ◽  
M Nieda ◽  
T Juji ◽  
...  

1997 ◽  
Vol 56 ◽  
pp. 379
Author(s):  
H. Direskeneli ◽  
E. Ekşioǧlu-Demiralp ◽  
T. Ergun ◽  
T. Lehner ◽  
T. Akoǧlu

2010 ◽  
Vol 12 (3) ◽  
pp. R109 ◽  
Author(s):  
Antonina Accardo-Palumbo ◽  
Anna Rita Giardina ◽  
Francesco Ciccia ◽  
Angelo Ferrante ◽  
Alfonso Principato ◽  
...  

2014 ◽  
Vol 21 (1) ◽  
pp. 46
Author(s):  
Ji Won Kim ◽  
Jeung Hui Pyo ◽  
Kyeong Jin Kim ◽  
Ho Kim ◽  
Yong Jeoung ◽  
...  

1995 ◽  
Vol 3 (2) ◽  
pp. 63-72 ◽  
Author(s):  
Kimitaka Sagawa ◽  
Kyogo Itoh ◽  
Minako Sakaguchi ◽  
Makoto Tamai ◽  
Sunao Sugita ◽  
...  

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Fumio Kaneko ◽  
Ari Togashi ◽  
Sanae Saito ◽  
Hideo Sakuma ◽  
Noritaka Oyama ◽  
...  

Adamantiades-Behçet's disease (ABD) is characterized by starting with oral aphthous ulceration and developing of the systemic involvements. The pathogenesis of ABD is closely correlated with the genetic factors and the triggering factors which acquire delayed-type hypersensitivity reaction against oralstreptococcimediated by IL-12 cytokine family. HLA-B51 is associated in more than 60% of the patients and its restricted CD8+ T cell response is clearly correlated with the target tissues.Bes-1gene encoded partialS. sanguinisgenome which is highly homologous with retinal protein, and 65 kD heat shock protein (Hsp-65) released from streptococci is playing an important role with human Hsp-60 in the pathogenesis of ABD. Although Hsp-65/60 has homologies with the respective T cell epitope, it stimulates peripheral blood mononuclear cells (PBMCs) from ABD patients. On the other hand, some peptides of Hsp-65 were found to reduce IL-8 and IL-12 production from PBMCs of ABD patients in active stage.


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