Evidence of opiates and opioid neuropeptides and their immune effects in parasitic invertebrates representing three different phyla: Schistosoma Mansoni, Theromyzon Tessulatum, Trichinella Spiralis

2000 ◽  
Vol 51 (2-4) ◽  
pp. 331-341 ◽  
Author(s):  
S. C. Pryor ◽  
R. Elizee
Keyword(s):  
Schistosoma Mansoni ◽  
Trichinella Spiralis ◽  
Opioid Neuropeptides

Immunity to Onchocerca lienalis microfilariae in mice

1985 ◽  
Vol 59 (4) ◽  
pp. 337-346 ◽  
Author(s):  
Simon Townson ◽  
G. S. Nelson ◽  
A. E. Bianco
Keyword(s):  
Schistosoma Mansoni ◽  
Adult Male ◽  
Partial Resistance ◽  
Primary Infection ◽  
Trichinella Spiralis ◽  
Negligible Effect ◽  
Species Specific ◽  
Dipetalonema Viteae

ABSTRACTThe model of Onchocerca lienalis microfilariae (mff) injected into CBA and T.O. strains of mice has been used to examine immunity to skin-dwelling microfilariae following exposure to a range of species oF nelmmms Mice which had received a primary infection with O. cervicalis mff were significantly resistant to challenge with O. lienalis mfT(58% reduction relative to challenge controls). Immunization with the uterine contents (eggs and mff) of O. lienalis, O. gutturosa or O. volvulus conferred equivalent levels of protection agains challenge with O. lienalis mff (66 to 75%). Similar results were obtained with immunizations in mice that employed either fresh or freeze-killed eggs of O. gutturosa. Significant reductions in the recoveries of O. lienalis mff were also demonstrated following the intraperitoneal implantation of adult male worms of O. gutturosa (30 to 52%), the adults of either sex of Dipetalonema viteae (60%), or after infection witn Trichinella spiralis (27 to 81%). Infections with the trematode, Schistosoma mansoni, had a negligible effect on mff recoveries. It is concluded that partial resistance in mice to Onchocerca mff may be stimulated by factors, yet to be determined, that are neither stage nor species-specific.

Eosinophilia in Kenyan baboons (Papio anubis) induced by Trichinella spiralis and Schistosoma mansoni

Parasitology ◽  
1977 ◽  
Vol 75 (1) ◽  
pp. 89-100 ◽  
Author(s):  
R. F. Sturrock ◽  
A. E. Butterworth ◽  
S. D. Karamsadkar ◽  
R. Kimani ◽  
M. Imbuga ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Intravenous Injection ◽  
Trichinella Spiralis ◽  
Particulate Material ◽  
Cross Resistance ◽  
Patent Period ◽  
Papio Anubis ◽  
Oral Infections ◽  
Intravenous Injections ◽  
Oral Doses

High primary doses of Trichinella spiralis administered orally to Kenyan baboons (Papio anubis) induced a marked but unpredictable eosinophilia which started 2–3 weeks after infection and persisted as erratic waves for at least 6 months. Low primary oral doses induced no eosinophilia but a later, high challenge gave an accelerated eosino-philic response, although the peak was lower than in high primary infection. Intravenous injection of infective T. spiralis larvae resulted in a predictable, rapid eosinophilic response which persisted for several weeks. Intravenous injection of a particulate material, Sepharose, gave no oesinophilic response.Percutaneous Schistosoma mansoni infection of baboons resulted in a two-stage eosinophilic response: an initial rise occurred about ⅔ of the way through the pre-patent period and was followed by a second rise at the onset of patency. After peaking, the eosinophilia waned erratically over the next 3 or 4 weeks.A strong antibody response, measured by countercurrent imnruno-electrophoresis, was given in oral infections with T. spiralis, but intravenous injections elicited little or no antibody formation. Parasitological evidence indicated no cross-resistance to S. mansoni in baboons injected with T. spiralis 9 days previously. Thus, the intravenous injection of infective T. spiralis larvae appears to be a suitable method of inducing experimentally a non-specific eosinophilia to investigate possible immune mechanisms to S. mansoni in the baboon.

Trichinella spiralis and Schistosoma mansoni: Specificity of in vitro, leukocyte-mediated histamine release from rabbit platelets

1971 ◽  
Vol 29 (2) ◽  
pp. 263-270 ◽  
Author(s):  
Edward J. Colwell ◽  
John R. Ortaldo ◽  
Maurice J. Schoenbechler ◽  
John F. Barbaro ◽  
Earl H. Fife
Keyword(s):  
Schistosoma Mansoni ◽  
Histamine Release ◽  
Trichinella Spiralis ◽  
Rabbit Platelets

Immuno-therapeutic potential of Schistosoma mansoni and Trichinella spiralis antigens in a murine model of colon cancer

2018 ◽  
Vol 37 (1) ◽  
pp. 47-56
Author(s):  
Maha M. Eissa ◽  
Cherine A. Ismail ◽  
Mervat Z. El-Azzouni ◽  
Amany A. Ghazy ◽  
Mona A. Hadi
Keyword(s):  
Colon Cancer ◽  
Schistosoma Mansoni ◽  
Murine Model ◽  
Therapeutic Potential ◽  
Trichinella Spiralis

scholarly journals Anti-Arthritic Activity of Schistosoma mansoni and Trichinella spiralis Derived-Antigens in Adjuvant Arthritis in Rats: Role of FOXP3+ Treg Cells

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0165916 ◽  
Author(s):  
Maha M. Eissa ◽  
Dalia K. Mostafa ◽  
Amany A. Ghazy ◽  
Mervat Z. El azzouni ◽  
Laila M. Boulos ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Adjuvant Arthritis ◽  
Trichinella Spiralis ◽  
Treg Cells
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