Transdermal 17β-estradiol combined with oral progestogen increases plasma levels of insulin-like growth factor-l in postmenopausal women

1992 ◽  
Vol 15 (7) ◽  
pp. 533-538 ◽  
Author(s):  
J. Slowinska-Srzednicka ◽  
S. Zgliczynski ◽  
W. Jeske ◽  
U. Stopinska-Gluszak ◽  
M. Srzednicki ◽  
...  
Keyword(s):  
Growth Factor ◽  
Postmenopausal Women ◽  
Plasma Levels ◽  
Insulin Like Growth Factor ◽  
17Β Estradiol

92296201 Transdermal 17-estradiol combined with oral progestogen increases plasma levels of insulin-like growth factor-I in postmenopausal women

Maturitas ◽  
1993 ◽  
Vol 16 (3) ◽  
pp. 208-209
Author(s):  
J. Slowinska-Srzednicka ◽  
S. Zgliczynski ◽  
W. Jeske ◽  
U. Stopinska-Gluszak ◽  
M. Srzednicki ◽  
...  
Keyword(s):  
Growth Factor ◽  
Postmenopausal Women ◽  
Plasma Levels ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

scholarly journals Green Tea Catechin Extract Supplementation Does Not Influence Circulating Sex Hormones and Insulin-Like Growth Factor Axis Proteins in a Randomized Controlled Trial of Postmenopausal Women at High Risk of Breast Cancer

2019 ◽  
Vol 149 (4) ◽  
pp. 619-627 ◽  
Author(s):  
Hamed Samavat ◽  
Anna H Wu ◽  
Giske Ursin ◽  
Carolyn J Torkelson ◽  
Renwei Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Placebo Group ◽  
Growth Factor ◽  
Postmenopausal Women ◽  
Green Tea ◽  
Sex Hormones ◽  
Repeated Measures ◽  
Insulin Like Growth Factor ◽  
Mixed Effect ◽  
Hormonal Modulation

ABSTRACT Background Consumption of green tea has been associated with reduced risk of breast cancer. Hormonal modulation has been suggested as one of the potential underlying mechanisms; however, it has yet to be fully elucidated in large, long-term human clinical trials. Objective We investigated the effects of decaffeinated green tea extract (GTE) on circulating sex hormones and insulin-like growth factor (IGF) proteins. Methods We conducted a placebo-controlled double-blind randomized clinical trial recruiting from 8 clinical centers in Minnesota. Participants were 538 healthy postmenopausal women randomly assigned to the GTE group (463 completed the study; mean age = 60.0 y) and 537 to the placebo group (474 completed; mean age = 59.7 y). Women in the GTE group orally took 4 decaffeinated capsules containing 1315 mg total catechins including 843 mg epigallocatechin-3-gallate daily for 1 y, whereas women in the placebo group took similar capsules containing no tea catechins. Blood sex hormones (estrone, estradiol, androstenedione, testosterone, and sex hormone-binding globulin) and IGF proteins (IGF-1 and IGF binding protein-3) were quantified at baseline and months 6 (for IGF proteins only) and 12, and were assessed as secondary outcomes of the study using a mixed-effect repeated-measures ANOVA model. Results Women in the GTE group had significantly higher blood total estradiol (16%; P = 0.02) and bioavailable estradiol (21%; P = 0.03) than in the placebo group at month 12. There was a statistically significant interaction between GTE supplementation and duration of treatment on estradiol and bioavailable estradiol (both Ps for interaction = 0.001). The catechol-O-methyltransferase genotype did not influence blood sex hormones before or after GTE supplementation. The circulating concentrations of IGF proteins were comparable between GTE and placebo groups at all 3 time points. Conclusion These results suggest that a 12-mo GTE supplementation significantly increases circulating estradiol concentrations in healthy postmenopausal women. This trial was registered at clinicaltrials.gov as NCT00917735.

Variation in plasma levels of insulin-like growth factor-I (IGF-I) in lingcod: relationships among season, size, and gonadal steroids

2010 ◽  
Vol 158 (2) ◽  
pp. 439-450 ◽  
Author(s):  
Anne H. Beaudreau ◽  
Kelly S. Andrews ◽  
Donald A. Larsen ◽  
Graham Young ◽  
Brian R. Beckman
Keyword(s):  
Growth Factor ◽  
Plasma Levels ◽  
Gonadal Steroids ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

scholarly journals Apelin abrogates the stimulatory effects of 17β-estradiol and insulin-like growth factor-1 on proliferation of epithelial and granulosa ovarian cancer cell lines via crosstalk between APLNR and ERα/IGF1R

2019 ◽  
Vol 46 (6) ◽  
pp. 6325-6338
Author(s):  
Marta Hoffmann ◽  
Justyna Gogola ◽  
Anna Ptak
Keyword(s):  
Ovarian Cancer ◽  
Growth Factor ◽  
Cell Lines ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Lines ◽  
The Body ◽  
Insulin Like Growth Factor ◽  
Ovarian Cancer Cell Lines ◽  
17Β Estradiol

Abstract Apelin and chemerin are adipocytokines that play important roles in many physiological and pathological processes throughout the body. Our previous study demonstrated that these two adipokines are expressed and secreted by epithelial and granulosa cancer cell lines. 17β-estradiol (E2) and insulin-like growth factor-1 (IGF-1) are important regulators of ovarian functions, and their roles are well known. This study investigated whether apelin and chemerin regulate proliferation and apoptosis of epithelial (OVCAR-3) and granulosa (COV434) ovarian cancer cell lines by interacting with E2 and IGF-1. Apelin and chemerin did not affect caspase-3 activation in either cell line. However, apelin abrogated the stimulatory effects of E2 on proliferation of OVCAR-3 cells and of IGF-1 on proliferation of COV434 cells independently of ERK1/2 and PI3K via crosstalk of apelin receptor with estrogen receptor alpha and IGF-1 receptor, respectively.

Age-Sensitive Cognitive Function, Growth Hormone and Insulin-Like Growth Factor 1 Plasma Levels in Healthy Older Men

2000 ◽  
Vol 41 (2) ◽  
pp. 73-78 ◽  
Author(s):  
André Aleman ◽  
Wouter R. de Vries ◽  
Edward H.F. de Haan ◽  
Harald J.J. Verhaar ◽  
Monique M. Samson ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cognitive Function ◽  
Growth Factor ◽  
Plasma Levels ◽  
Older Men ◽  
Insulin Like Growth Factor
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