Body Composition Modulates the Effects of Hormone Replacement Therapy on Growth Hormone and Insulin-Like Growth Factor-I Levels in Postmenopausal Women

2002 ◽  
Vol 54 (4) ◽  
pp. 201-206 ◽  
Author(s):  
Arturo Figueroa ◽  
Scott B. Going ◽  
Laura A. Milliken ◽  
Robert Blew ◽  
Sarah Sharp ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Hormone Replacement Therapy ◽  
Growth Factor ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Hormone Replacement ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

The insulin-like growth factor-I system and hormone replacement therapy

2001 ◽  
Vol 75 (2) ◽  
pp. 282-287 ◽  
Author(s):  
Hilton José Pereira Cardim ◽  
Ceci Mendes Carvalho Lopes ◽  
Daniel Giannella-Neto ◽  
Angela Maggio da Fonseca ◽  
José Aristodemo Pinotti
Keyword(s):  
Hormone Replacement Therapy ◽  
Growth Factor ◽  
Replacement Therapy ◽  
Hormone Replacement ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

scholarly journals Effects of Human Growth Hormone, Insulin-Like Growth Factor I, and Diet and Exercise on Body Composition of Obese Postmenopausal Women1

1998 ◽  
Vol 83 (5) ◽  
pp. 1477-1484 ◽  
Author(s):  
J. L. Thompson ◽  
G. E. Butterfield ◽  
U. K. Gylfadottir ◽  
J. Yesavage ◽  
R. Marcus ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Composition ◽  
Growth Factor ◽  
Muscle Strength ◽  
Postmenopausal Women ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Diet And Exercise ◽  
Igf I ◽  
Growth Factor I

To determine the effects of GH and insulin-like growth factor I (IGF-I) administration, diet, and exercise on weight loss, body composition, basal metabolic rate (BMR), muscle strength, and psychological status, 33 moderately obese postmenopausal women (67.1 ± 5.2 yr) participated in a 12-week randomized, double blind study. Participants were placed on a diet that provided 500 Cal/day less than that needed for weight maintenance, and they walked 3 days and strength trained 2 days each week. Subjects also self-injected GH (0.025 mg/kg BW·day), IGF-I (0.015 mg/kg BW·day), a combination of these doses of GH and IGF-I, or placebo (P). Twenty-eight women completed the study, as five subjects dropped out due to intolerable side-effects (e.g. edema). Weight loss occurred in all groups, with the largest decrease occurring in the GH plus IGF-I group (5.6 ± 1.4 kg). Fat mass significantly decreased in all groups, with the largest losses observed in GH and GH plus IGF-I groups (6.3 ± 1.8 and 8.4 ± 2.8 kg, respectively). Despite weight loss, BMR was maintained in all groups. Muscle strength increased with training for all groups, and depression and anxiety scores decreased in groups receiving IGF-I. These data show that obese postmenopausal women can lose weight and fat without compromising fat free mass, BMR, or gains in muscle strength, and that GH and IGF-I given together may enhance fat loss over either given alone.

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