Fatty acid induced changes in circulating total and free thyroid hormones: in vivo effects and methodological artefacts

1986 ◽  
Vol 9 (2) ◽  
pp. 121-126 ◽  
Author(s):  
W. J. H. Vermaak ◽  
W. J. Kalk ◽  
J. M. Kuyl ◽  
A. M. Smit
Keyword(s):  
Fatty Acid ◽  
Thyroid Hormones ◽  
Free Thyroid Hormones ◽  
Induced Changes ◽  
In Vivo Effects

In vivo effects of N/OFQ(1–13)NH2 and its structural analogue [ORN9]N/OFQ(1–13)NH2 on carrageenan-induced inflammation: rat-paw oedema and antioxidant status

2009 ◽  
Vol 4 (2) ◽  
pp. 170-178 ◽  
Author(s):  
Rositsa Zamfirova ◽  
Elina Tzvetanova ◽  
Albena Alexandrova ◽  
Lubomir Petrov ◽  
Polina Mateeva ◽  
...  
Keyword(s):  
Antioxidant Status ◽  
Time Intervals ◽  
Structural Analogue ◽  
Paw Oedema ◽  
The Right ◽  
Rat Paw ◽  
Induced Changes ◽  
In Vivo Effects ◽  
Rat Paw Oedema

AbstractThe effects of nociceptin(1–13)NH2 (N/OFQ(1–13)NH2) and its structural analogue [Orn9]N/OFQ(1–13)NH2 on acute carrageenan (CG)-induced peripheral inflammation and paw antioxidant status were studied. CG was injected intraplantarly in the right hind paw of rats and the volume of the inflamed paw was measured each 30 min for a period of 4h. When administered simultaneously with CG, N/OFQ(1–13)NH2 decreased the paw volume, whereas if injected 15 min before CG it had no effect. [Orn9]N/OFQ(1–13)NH2 produced the opposite effects at the same time-intervals of its administration. We also investigated whether these neuropeptides influence CG-induced changes in cell antioxidant system, especially at the 4th hour of CG administration. CG alone decreased the glutathione level and superoxide dismutase activity, as measured in post-nuclear homogenate of the inflamed paw. However, CG injection increased glutathione peroxidase and glucose-6-phospate dehydrogenase activities, while the activity of glutathione reductase was unchanged. The peptides themselves did not change all measured parameters. Moreover, neither N/OFQ(1–13)NH2 nor [Orn9]N/OFQ(1–13)NH2 modified CG-induced changes in the antioxidant status, regardless of the time of their injection (simultaneously or 15 min before CG). The present results suggest that N/OFQ(1–13)NH2 and [Orn9]N/OFQ(1–13)NH2 most likely affect the neuronal inflammation, rather than act as pro- or antioxidants.

In vivo effects of thyroid hormones on bone metabolism in adult mice

Bone ◽  
1992 ◽  
Vol 13 (5) ◽  
pp. A39-A39
Author(s):  
M. Yamamoto ◽  
R. Balena ◽  
A. Markatos ◽  
G.A. Rodan
Keyword(s):  
Thyroid Hormones ◽  
Bone Metabolism ◽  
Adult Mice ◽  
In Vivo Effects

In vitro and in vivo effects of selenium and selenium with vitamin E on platelet functions in diabetic rats relationship to platelet sorbitol and fatty acid distribution

1996 ◽  
Vol 55 (3) ◽  
pp. 263-277 ◽  
Author(s):  
Christelle Douillet ◽  
Muriel Bost ◽  
Michèle Accominotti ◽  
Françoise Borson-Chazot ◽  
Maryvonne Ciavatti
Keyword(s):  
Fatty Acid ◽  
Vitamin E ◽  
Fatty Acid Distribution ◽  
Diabetic Rats ◽  
In Vivo Effects ◽  
Platelet Functions

The Effect of Korean Red Ginseng on Bisphenol A-Induced Fatty Acid Composition and Lipid Metabolism-Related Gene Expression Changes

2020 ◽  
Vol 48 (08) ◽  
pp. 1841-1858
Author(s):  
Joonwoo Park ◽  
KeunOh Choi ◽  
Jeonggeun Lee ◽  
Jong-Min Jung ◽  
YoungJoo Lee
Keyword(s):  
Fatty Acid ◽  
Lipid Metabolism ◽  
Bisphenol A ◽  
Cholesterol Biosynthesis ◽  
Red Ginseng ◽  
Lipid Profiling ◽  
Korean Red Ginseng ◽  
Endocrine Disrupting Chemical ◽  
Induced Changes

Bisphenol A (BPA), which is known to be an endocrine-disrupting chemical (EDC), is associated not only with estrogen activity and reproductive toxicity but also with a variety of metabolic disorders. BPA affects glucose tolerance, cholesterol biosynthesis, and fatty acid synthesis. Ginseng is a traditional medicinal plant that has been widely used in East Asia for more than 2000 years, and a number of health effects have been reported. Korean Red Ginseng (KRG) has also been shown to have effects on lipid metabolism and body weight reduction in vivo in obese mice. In this study, we administered BPA and KRG to ovariectomized (OVX) ICR mice. BPA (800 mg/kg/day) and KRG (1.2 g/kg/day) were orally administered to OVX mice for 3 days. KRG inhibited the increase in total fatty acid level by BPA as determined by lipid profiling in the liver of OVX mice. In addition, transcriptome analysis showed that KRG inhibited BPA-induced changes in lipid metabolic process-related genes. Our findings suggest that KRG can regulate BPA-induced changes in lipid metabolism.

Cadmium-induced changes of antioxidant and metabolic status in red blood cells of rats: in vivo effects

2009 ◽  
Vol 51 (2) ◽  
pp. 86-92 ◽  
Author(s):  
M. M. Kostić ◽  
B. Ognjanović ◽  
S. Dimitrijević ◽  
R. V. Zikić ◽  
A. ZSCtajn ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Metabolic Status ◽  
Induced Changes ◽  
In Vivo Effects

scholarly journals Tissue-specific regulation of medium-chain acyl-CoA dehydrogenase gene by thyroid hormones in the developing rat

1997 ◽  
Vol 324 (1) ◽  
pp. 289-294 ◽  
Author(s):  
Fatima DJOUADI ◽  
Béatrice RIVEAU ◽  
Claudie MERLET-BENICHOU ◽  
Jean BASTIN
Keyword(s):  
Gene Expression ◽  
Enzyme Activity ◽  
Fatty Acid ◽  
Thyroid Hormones ◽  
Mrna Abundance ◽  
Tissue Specific ◽  
Medium Chain ◽  
Chain Acyl ◽  
Specific Regulation

During development, gene expression of medium-chain acyl-CoA dehydrogenase (MCAD), a nuclear-encoded mitochondrial enzyme that catalyses the first step of medium-chain fatty acid β-oxidation, is highly regulated in tissues in accordance with fatty acid utilization, but the factors involved in this regulation are largely unknown. To investigate a possible role of thyroid hormones, rat pups were made hypothyroid by the administration of propylthiouracyl to the mother from day 12 of gestation, and their kidneys, heart and liver were removed on postnatal day 16 to determine MCAD mRNA abundance, protein level and enzyme activity. Similar experiments were run in 3,3′,5-tri-iodothyronine (T3)-replaced hypothyroid (1 μg of T3/100 g body weight from postnatal day 5 to 15) and euthyroid pups. Hypothyroidism led to an increase in MCAD mRNA abundance in kidney and a decrease in abundance in heart, but had no effect in liver. The protein levels and enzyme activity were lowered in hypothyroid heart and kidney, suggesting that hypothyroidism affects post-transcriptional steps of gene expression in the kidney. All the effects of hypothyroidism were completely reversed in both heart and kidney by T3 replacement. Injection of a single T3 dose into 16-day-old euthyroid rats also led to tissue-specific changes in mRNA abundance. Nuclear run-on assays performed from hypothyroid and hypothyroid plus T3 rats showed that T3 stimulates MCAD gene transcription in heart and represses it in the kidney. These results indicate that the postnatal rise in circulating T3 is essential to the developmental regulation of the MCAD gene in vivo.

scholarly journals TSH receptor activation and body composition

2009 ◽  
Vol 204 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Anna de Lloyd ◽  
James Bursell ◽  
John W Gregory ◽  
D Aled Rees ◽  
Marian Ludgate
Keyword(s):  
Body Composition ◽  
Adipose Tissue ◽  
Thyroid Hormones ◽  
Receptor Activation ◽  
Biologically Active ◽  
Free Thyroid Hormones ◽  
Experimental Approaches

The impacts of hyper and hypothyroidism on body composition, i.e. the relative quantity and quality of bone, adipose tissue and muscle, have traditionally been attributed uniquely to abnormal levels of free thyroid hormones. The presence of biologically active TSH receptors in bone, fat and muscle, raises the possibility that both thyroid hormones and TSH contribute to the changes in body composition associated with thyroid disease. This review evaluates the evidence for this in terms of the in vitro experimental approaches applied, data from in vivo sources (i.e. mouse models) and patient-based studies.

In Vivo Effects of Amiodarone on Cardiac β-Adrenoceptor Density and Heart Rate Require Thyroid Hormones

1992 ◽  
Vol 19 (4) ◽  
pp. 541-545 ◽  
Author(s):  
Ya-Lin Yin ◽  
Gérard Yves Perret ◽  
Patrick Nicolas ◽  
Roger Vassy ◽  
Bernard Uzzan ◽  
...  
Keyword(s):  
Heart Rate ◽  
Thyroid Hormones ◽  
In Vivo Effects

Isopropyldiiodothyronine and α-methylthyroxine: Comparison of their in vitro and in vivo effects with those of thyroid hormones

1976 ◽  
Vol 25 (15) ◽  
pp. 1757-1762
Author(s):  
Nicolas Zenker ◽  
Roger Truchot ◽  
Hervé Goudonnet ◽  
Bernard Chaillot ◽  
Raymond Michel
Keyword(s):  
Thyroid Hormones ◽  
In Vivo Effects
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