Three-week integrated body weight reduction programme markedly improves performance and work capacity in severely obese patients

2003 ◽  
Vol 8 (2) ◽  
pp. 107-113 ◽  
Author(s):  
A. Sartorio ◽  
S. Ottolini ◽  
F. Agosti ◽  
M. Massarini ◽  
C. L. Lafortuna
Keyword(s):  
Body Weight ◽  
Weight Reduction ◽  
Work Capacity ◽  
Obese Patients ◽  
Body Weight Reduction ◽  
Severely Obese

scholarly journals Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie-Restricted Diet

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Karolina Szewczyk-Golec ◽  
Paweł Rajewski ◽  
Marcin Gackowski ◽  
Celestyna Mila-Kierzenkowska ◽  
Roland Wesołowski ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Weight Reduction ◽  
Serum Levels ◽  
Significant Rise ◽  
Obese Patients ◽  
Restricted Diet ◽  
Body Weight Reduction ◽  
Show Evidence ◽  
Group A

Obesity is one of the major global health problems. Melatonin deficiency has been demonstrated to correlate with obesity. The aim of the study was to estimate the effect of melatonin on oxidative stress and adipokine levels in obese patients on a calorie-restricted diet. Thirty obese patients were supplemented with a daily dose of 10 mg of melatonin (n=15) or placebo (n=15) for 30 days with a calorie-restricted diet. Serum levels of melatonin, 4-hydroxynonenal (HNE), adiponectin, omentin-1, leptin, and resistin, as well as erythrocytic malondialdehyde (MDA) concentration and Zn/Cu-superoxide dismutase, catalase, and glutathione peroxidase (GPx) activities, were measured at baseline and after supplementation. Significant body weight reduction was observed only in the melatonin group. After melatonin supplementation, the adiponectin and omentin-1 levels and GPx activities statistically increased, whereas the MDA concentrations were reduced. In the placebo group, a significant rise in the HNE and a drop in the melatonin concentrations were found. The results show evidence of increased oxidative stress accompanying calorie restriction. Melatonin supplementation facilitated body weight reduction, improved the antioxidant defense, and regulated adipokine secretion. The findings strongly suggest that melatonin should be considered in obesity management. This trial is registered with CTRI/2017/07/009093.

scholarly journals Effects of a 3-Week In-Hospital Multidisciplinary Body Weight Reduction Program in Obese Females: Is Measured Resting Energy Expenditure Essential for Tailoring Adequately the Amount of Energy Intake?

2021 ◽  
Vol 8 ◽  
Author(s):  
Sofia Tamini ◽  
Sabrina Cicolini ◽  
Diana Caroli ◽  
Alessandro Sartorio
Keyword(s):  
Body Weight ◽  
Energy Expenditure ◽  
Energy Intake ◽  
Weight Reduction ◽  
Resting Energy Expenditure ◽  
Weight Reduction Program ◽  
Body Weight Reduction ◽  
Diet Plan ◽  
Reduction Program ◽  
Severely Obese

In the obese population, the prescription of a proper diet plan is essential to ensure an appropriate and gradual weight loss, reduce the risk of weight cycling and favor an overall improvement of health conditions. Energy needs are commonly estimated using predictive equations, even if their accuracy is still debated, especially in severely obese subjects. In the present study, 850 severely obese females admitted to our hospital for a multidisciplinary body weight reduction program (BWRP) were divided into three subgroups, “hypo-,” “normo-,” and “hyper-metabolic,” based on the comparison between estimated resting energy expenditure (eREE, using the Mifflin equation) and measured REE (mREE, using indirect calorimetry). The majority of this study population was considered normo-metabolic (59.4%, mREE between 90 and 110% of eREE), 32.6% was hyper-metabolic (mREE > 110% of eREE) and only 8% was hypo-metabolic (mREE < 90% of eREE). The three subgroups were evaluated before and after a 3-week BWRP, entailing energy restricted diet, adapted physical activity, psychological counseling and nutritional education. Since the diet plan during the BWRP consisted of a 30% reduction of total energy expenditure (obtained by multiplying mREE by the physical activity level), each subgroup responded positively to the BWRP independently from the difference between mREE and eREE, the extent of BMI reduction and clinical, metabolic and physical amelioration being comparable among the three subgroups. By contrast, the restriction of the energy intake based on eREE during the BWRP would have determined a slighter caloric restriction in the hypo-metabolic subgroup, thus determining a smaller body weight reduction, and, by contrast, a more marked caloric restriction in the hyper-metabolic subgroup, probably difficult to be tolerated and maintained for prolonged period. In conclusion, the percentage of subjects with “slow metabolism” in a Caucasian female obese population seeking hospitalization for a BWRP is actually lower than expected, finding controverting the common notion that obesity is mostly due to reduced REE. The high percentage (40%) of inadequate eREE in these female obese populations further underlines the absolute need to include the measurement of REE in the clinical practice for the correct prescription of energy intake in severely obese populations.

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