Short Term and Long Term Studies in Arthritics

InPharma ◽  
1984 ◽  
Vol 446 (1) ◽  
pp. 7-8
Keyword(s):  
2017 ◽  
Vol 10 (1) ◽  
pp. 31-34 ◽  
Author(s):  
Jessica Butts ◽  
Bret Jacobs ◽  
Matthew Silvis

Context: The use of creatine as a dietary supplement has become increasingly popular over the past several decades. Despite the popularity of creatine, questions remain with regard to dosing, effects on sports performance, and safety. Evidence Acquisition: PubMed was searched for articles published between 1980 and January 2017 using the terms creatine, creatine supplementation, sports performance, and dietary supplements. An additional Google search was performed to capture National Collegiate Athletic Association–specific creatine usage data and US dietary supplement and creatine sales. Study Design: Clinical review. Level of Evidence: Level 4. Results: Short-term use of creatine is considered safe and without significant adverse effects, although caution should be advised as the number of long-term studies is limited. Suggested dosing is variable, with many different regimens showing benefits. The safety of creatine supplementation has not been studied in children and adolescents. Currently, the scientific literature best supports creatine supplementation for increased performance in short-duration, maximal-intensity resistance training. Conclusion: While creatine appears to be safe and effective for particular settings, whether creatine supplementation leads to improved performance on the field of play remains unknown.


1994 ◽  
Vol 45 (1) ◽  
pp. 203 ◽  
Author(s):  
RD Davis ◽  
S Chakraborty ◽  
DF Cameron ◽  
JAG Irwin ◽  
RM Boland

The effectiveness of using accession mixtures of Stylosanthes spp. to manage anthracnose (Colletotrichum gloeosporioides) in pastures in northern Australia was examined during three consecutive years. Two mixtures containing six accessions were compared with the components grown as pure stands. No significant differences in anthracnose incidence (proportion of infected plants/plot) were indicated between the two mixtures and the mean incidence of their respective components grown in pure swards. Areas under the disease progress curves for the accessions were not significantly different between pure and mixed stands of the cultivars other than Seca and Verano. Resistant cultivar Seca developed more disease in a mixture than in a pure stand, and moderately resistant Verano had less disease in a mixture than in a pure stand. In the short term, no apparent anthracnose control advantage is achieved in highly susceptible accessions of Stylosanthes spp. when they are included in mixtures with less susceptible accessions. Long term studies involving grazing animals are necessary to adequately evaluate control of this disease through the use of mixtures.


2017 ◽  
Vol 68 (3) ◽  
pp. 563
Author(s):  
Ruber Rodríguez-Barreras ◽  
Julián López-Morell ◽  
Alberto M. Sabat

A reliable and harmless mark–recapture method provides valuable information for the management of commercial sea cucumber species. Nevertheless, marking and tracking sea cucumbers is notoriously difficult and represents a serious challenge. In this study, we tested one external and one internal tag in the sea cucumber Holothuria grisea. A passive integrated transponder (PIT) tag was inserted into the coelomic cavity in one treatment, whereas a T-bar (external tag) was attached in the upper surface of the body wall in the other treatment; sea cucumbers were then followed for 17 weeks. The tagging procedure caused no evisceration in the experimental groups, nor was a significant difference in growth rate found between treatments. The retention of the PIT tag was low, with 100% lost by Week 9. Retention of T-bars was higher, with 90% still attached by the end of the Week 8, but retention decreased thereafter as T-bar absorption increased. No relationship was found between initial weight and the number of weeks PIT tags (r=–0.173, P=0.781) or T-bars (r=–0.220, P=0.652) were retained. Neither the T-bar nor the PIT tags fulfilled the requirements of high retention required for long-term studies. However, we do recommend the use of T-bars for short-term studies for H. grisea under laboratory conditions or in a habitat with low substrate complexity.


1989 ◽  
Vol 113 (3) ◽  
pp. 401-406 ◽  
Author(s):  
G. B. Robbins ◽  
J. J. Bushell ◽  
G. M. McKeon

SUMMARYThe extent and rate of N release from nylon bags containing green panic (Panicum maximumvar.trichoglume)litter was measured for up to 319 days (long-term studies) in 1978/79 and 1979/80 in Gayndah, Australia. Dry matter (DM) decomposition rates were measured in 41 periods of 39 days and related to environmental variables and initial litter N concentrations (short-term study).About half of litter DM decomposed during the long-term studies, while N concentration in the remaining litter increased from an initial average of 0–57 % N, to 0–95 % N. Net release of N from bags began when its concentration in the residue increased to c.0–65% N (or when the C:N ratio decreased to 75:1). Only a net 20–30 % of the initial N was released for potential plant uptake by the end of the study. The short-term study showed that DM decomposition was rapid and independent of pasture age. Decomposition rate increased with soil moisture and average daily temperature but was unaffected by initial litter N concentration. Release of N from decomposing litter was slow, despite rapid DM decomposition. It was concluded that a major cause of declining productivity in sown grass pastures is the immobilization of N in decomposing grass litter.


Author(s):  
Anushka Bhaskar ◽  
Jay Chandra ◽  
Danielle Braun ◽  
Jacqueline Cellini ◽  
Francesca Dominici

Background: As the coronavirus pandemic rages on, 692,000 (August 7, 2020) human lives and counting have been lost worldwide to COVID-19. Understanding the relationship between short- and long-term exposure to air pollution and adverse COVID-19 health outcomes is crucial for developing solutions to this global crisis. Objectives: To conduct a scoping review of epidemiologic research on the link between short- and long-term exposure to air pollution and COVID-19 health outcomes. Method: We searched PubMed, Web of Science, Embase, Cochrane, MedRxiv, and BioRxiv for preliminary epidemiological studies of the association between air pollution and COVID-19 health outcomes. 28 papers were finally selected after applying our inclusion/exclusion criteria; we categorized these studies as long-term studies, short-term time-series studies, or short-term cross-sectional studies. One study included both short-term time-series and a cross-sectional study design. Results: 27 studies of the 28 reported evidence of statistically significant positive associations between air pollutant exposure and adverse COVID-19 health outcomes; 11 of 12 long-term studies and all 16 short-term studies reported statistically significant positive associations. The 28 identified studies included various confounders, spatial and temporal resolutions of pollution concentrations, and COVID-19 health outcomes. Discussion: We discuss methodological challenges and highlight additional research areas based on our findings. Challenges include data quality issues, ecological study design limitations, improved adjustment for confounders, exposure errors related to spatial resolution, geographic variability in testing, mitigation measures and pandemic stage, clustering of health outcomes, and a lack of publicly available data and code.


1982 ◽  
Vol 76 (3) ◽  
pp. 91-100 ◽  
Author(s):  
Stuart Aitken ◽  
T. G. R. Bower

This study investigates the use of an ultrasonic sonar device—the Sonicguide™—by blind infants. Both short-term studies, lasting up to three days, and long-term studies, lasting up to two years, are reported. The importance of the selection of strict criteria for evaluating “use” of the device is emphasized. Using such criteria, age differences in ability to make effective use of the information provided by the device were found. These findings have important implications for any future intervention programs with blind infants.


2010 ◽  
Vol 06 (01) ◽  
pp. 63
Author(s):  
Michelle L Klein ◽  
Robert Rapaport ◽  
◽  

Short-term studies of children born small for gestational age (SGA) who do not adequately catch up have shown that growth hormone (GH) treatment over a range of doses is both safe and effective at increasing growth velocity and height standard deviation (SD). Long-term studies have shown an improvement in adult height compared with untreated controls. Predictors of growth response include height and weight at start of GH treatment, pre-treatment growth velocity, target height, and pre-pubertal years treated with GH. Height prediction models are being developed to help maximize GH treatment response. While some short-term studies of GH treatment in SGA children have shown abnormalities in carbohydrate metabolism, long-term studies have demonstrated that these changes were transient. GH treatment has been shown to be safe and effective in increasing adult height of children born SGA. Follow-up is needed for assessment of the long-term effects of GH treatment.


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