Linezolid lower-cost option for cellulitis in the UK

2001 ◽  
Vol 329 (1) ◽  
pp. 3-4
Keyword(s):  
The Uk ◽  
Author(s):  
Aldona Zawojska

The article is a contribution to the discussion on the anticipated consequences of the United Kingdom’s withdrawal from the European Union for Poland’s trade relations with this country, with particular emphasis on the likely impacts of a hard or no-deal Brexit on Polish exporters. Its aim is to provide readers with an understanding of how agri-food flows between Poland and the UK (especially Poland’s exports) could be affected once the UK departs the EU. The question is important considering that, in recent years, the UK has been the second biggest importer and a net importer of agricultural and food products from Poland. The study is based on trade data from the UN Comtrade Database and Poland’s Central Statistical Office, and on tariff data from the UK’s Department for International Trade. Taking into account the possible imposition of customs duties announced thus far by the British government on the import of agri-food products from third countries in the event of a no-trade agreement with the EU, the introduction of additional non-tariff barriers, as well as increased transactional (friction) costs and complexity of doing business with foreign partners, a hard Brexit would have serious implications for Poland’s fast growing agri-food exports to the UK. It would even lead to a collapse of some Polish supplies, particularly of meat and dairy commodities, to Great Britain. The loss of two-way preferences in trade now arising from participation in the EU single market will undermine the competitiveness of Polish producers on UK’s market both against British producers and lower cost exporters from outside the EU.


2021 ◽  
Author(s):  
José Afonso Guerra-Assunção ◽  
Paul A. Randell ◽  
Florencia A. T. Boshier ◽  
Michael A. Crone ◽  
Juanita Pang ◽  
...  

AbstractThe appearance of the SARS-CoV-2 lineage B.1.1.7 in the UK in late 2020, associated with faster transmission, sparked the need to find effective ways to monitor its spread. The set of mutations that characterise this lineage include a deletion in position 69 and 70 of the spike protein, which is known to be associated with Spike Gene Target Failure (SGTF) in a commonly used three gene diagnostic qPCR assay. The lower cost and faster turnaround times compared to whole genome sequencing make the use of qPCR for monitoring of the variant spread an attractive proposition. However, there are several potential issues with this approach. Here we use 826 SARS-CoV-2 samples collected in a hospital setting as part of the Hospital Onset COVID Infection (HOCI) study where qPCR was used for viral detection, followed by whole genome sequencing (WGS), to identify the factors to consider when using SGTF to infer lineage B.1.1.7 prevalence in a hospital setting, with potential implications for locations where this variant has recently been introduced.


2018 ◽  
Vol 133 (3) ◽  
pp. 338-346 ◽  
Author(s):  
Eric W. Hall ◽  
Eli S. Rosenberg ◽  
Monica Trigg ◽  
Noele Nelson ◽  
Sarah Schillie

Objectives: Infants born to mothers who are hepatitis B surface antigen (HBsAg) positive are at risk for perinatal hepatitis B infection. As prevention, these infants receive a series of 3 or 4 doses of hepatitis B vaccine starting at birth and postvaccination serologic testing. Infants with antibody levels <10 mIU/mL are considered vaccine nonresponders and should be revaccinated. The objective of this cost analysis was to assess a single-dose revaccination strategy among infant nonresponders. Methods: We used a decision analytic tree to compare the costs of a single-dose revaccination strategy with the costs of a 3-dose revaccination strategy. The analysis consisted of 3 epidemiologic scenarios that varied levels of previous protection among infants indicated for revaccination. We assumed health outcomes in each strategy were the same, and we evaluated costs from the societal perspective using 2016 US dollars. We conducted sensitivity analyses on key variables, including the minimum required efficacy of a single revaccination dose. Results: In all analyses, the single-dose revaccination strategy was a lower-cost option than the 3-dose revaccination strategy. Under the assumption that all revaccination visits were previously unscheduled, single-dose revaccination reduced the cost per infant by $119.81 to $155.72 (depending on the scenario). Across all scenarios, the most conservative estimate for the threshold efficacy (the minimum efficacy required to result in a lower-cost option) value of single-dose revaccination was 67%. Conclusions: For infants who were born to HBsAg-positive mothers and who were not responding to the initial vaccine series, a single-dose revaccination strategy, compared with a 3-dose revaccination strategy, reduced costs across several scenarios. These results helped inform the Advisory Committee on Immunization Practices’ vote in February 2017 to recommend single-dose revaccination.


Author(s):  
J K Raine ◽  
R J Henderson

Ambulance suspensions often give a poor ride, which may result in deterioration in the condition of ill or injured patients. Suspension of the ambulance stretcher itself is a lower cost option than a purpose- built ambulance suspension and may offer superior isolation of the patient from road-induced disturbances. This paper describes the development of a pneumatic stretcher suspension offering both pitch and heave isolation. Design and theoretical considerations are outlined, and preliminary performance figures reported. Subsequent parts of this paper will explore the dynamics of the system with pneumatic damping and report on the performance of the prototype suspension for a range of patient masses, damping levels and floor vibration inputs.


2013 ◽  
Vol 37 (3) ◽  
pp. 218-225 ◽  
Author(s):  
Malcolm Miles

In the global North, housing tends to be seen as a sub-sector of the construction industry. In the global South, in contrast, it might be considered more as a verb – housing as the activity of meeting basic needs for shelter. As such, this process is frequently undertaken by users themselves, in the informal settlements which surround most cities. While these settlements were once regarded as a threat to the urban order (or urbanization), today there is increasing recognition that self-build and self-managed housing meets the needs of urban development in ways which are usually more sustainable as well as lower-cost than standard housing schemes (whether in the public or the private sector). This paper begins from the question as to how far the lessons of informal settlements in the South can be applied in the North. It looks at the status of informal settlements in the new South Africa, and at two schemes in the UK: the Coin Street development in London, managed by tenants; and Ashley Vale self-build housing in Bristol, in southwest England. These are not seen as exemplary but simply two cases which can be compared and contrasted in the terrain of new approaches to building cities for the future.


2009 ◽  
Vol 2009 ◽  
pp. 69-69
Author(s):  
R W Annett ◽  
A F Carson

Rations for pregnant ewes in the UK are often based on grass silage. However, due to a number of factors, the cost of producing high quality grass silage has increased significantly in recent years so lower cost alternatives need to be investigated. Production of forage maize has the potential to reduce forage costs on mixed beef/sheep farms, with high dry-matter yields (comparable to that of a 3-cut silage system) of high quality maize silage possible from a single harvesting operation (Easson and Fearnehough, 2000). However there is limited information on the effects of feeding maize silage to pregnant ewes. Alternatively, grass silage could be eliminated from rations by feeding high grain diets. The aims of this study were to evaluate the effects of replacing grass silage with either maize silage or concentrates on the performance of housed pregnant ewes and their lambs.


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