scholarly journals 3.4 Fat Distribution and Cardiovascular Risk in Obese Women

2008 ◽  
Vol 15 (3) ◽  
pp. 194-194
Author(s):  
G. Salvetti ◽  
F. Santini ◽  
A. Pucci ◽  
D. Versari ◽  
A. Virdis ◽  
...  
2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Fernando Cordido ◽  
Jesús Garcia-Buela ◽  
Susana Sangiao-Alvarellos ◽  
Teresa Martinez ◽  
Ovidio Vidal

The aim of the present study was to evaluate the relationship between GHRH-induced GH secretion in obese premenopausal women and cardiovascular risk markers or insulin resistance. Premenopausal obese women, aged 35–52 years, were studied. GH secretion, IGF-I, serum cardiovascular risk markers, insulin, leptin, mid-waist and hip circumference, total body fat, and truncal fat were measured. Subjects were classified as meeting the criteria for GH deficiency (GHD) when peak GH after stimulation with GHRH was≤3 μg/L. Mean total and LDL cholesterol, fasting insulin, and HOMA-IR were all higher, in subjects who would have been classified as GH-deficient compared with GH-sufficient. Peak GH secretion after stimulation was inversely associated with fasting insulin (R=−0.650,P=.012), HOMA-IR (R=−0.846,P=.001), total cholesterol (R=−0.532,P=.034), and LDL cholesterol (R=−0.692,P=.006) and positively associated with HDL cholesterol (R=0.561,P=.037). These data strongly suggest a role for insulin resistance in the decreased GH secretion of obesity and that the blunted GH secretion of central obesity could be the pituitary expression of the metabolic syndrome.


2007 ◽  
Vol 27 (6) ◽  
pp. 313-320 ◽  
Author(s):  
Elena Rodríguez-Rodríguez ◽  
Rosa M. Ortega ◽  
Ana M. López-Sobaler ◽  
Pedro Andrés ◽  
Aránzazu Aparicio ◽  
...  

2010 ◽  
Vol 63 (1-2) ◽  
pp. 33-39 ◽  
Author(s):  
Aleksandra Simoncig-Netjasov ◽  
Svetlana Vujovic ◽  
Miomira Ivovic ◽  
Milina Tancic-Gajic ◽  
Milka Drezgic

Introduction. Hypoestrogenic status in the menopausal women shows a shift to a central android fat distribution and metabolic syndrome (MS). Related metabolic changes and hypertension increase the risk for cardiovascular (CV) diseases. The aim of this study was to investigate the influence of duration of menopause, anthropometric and hormonal parameters on metabolic syndrome. Material and methods. 50 obese women were examined with BMI=31.92?5.83 kg/m2, age 54.40?3.64, time since menopause 5.90?5.46 years. Control group consisted of 37 normal weight women with BMI=23.50?2.13 kg/m2, age 53.92?3.95, time since menopause 5.96?4.92 years. Anthropometric characteristics and blood pressure were measured. Blood was taken at 8 am for: fasting glucose, triglycerides, cholesterol, HDL, LDL, apolipoprotein A (ApoA), apolipoprotein B (ApoB), lipoprotein(a) (Lp(a)), C-reactive protein (CRP), fibrinogen, FSH, LH, prolactin, estradiol, progesterone, testosterone and sex hormone binding globulin (SHBG). Results. In obese women significant negative correlations were found for: BMI and HDL (p<0,05), waist and HDL (p<0,05), FSH and systolic blood pressure (p<0.01), FSH and fasting glucose (p<0,05), LH and waist (p<0.05), SHBG and fasting glucose (p<0.05). A positive correlation was found for lime since meno?pause and waist/hip ratio (p<0.05). In controls positive correlations were found for: waist/hip ratio and systolic and diastolic blood pressure (p<0,05), LH and HDL (p<0.05), estradiol and diastolic blood pressure (p<0,05). Negative correlations were detected for estradiol and waist (p<0,05), time since menopause and HDL (p<0,05). Conclusion. Gaining weight together with menopausal endocrine changes cause metabolic and hemodynamic imbalances, which contribute to risk for cardiovascular diseases.


1998 ◽  
Vol 7 (1) ◽  
pp. 1-12
Author(s):  
Roger L. Hammer ◽  
Daryl McCombs ◽  
A. Garth Fisher

It has been suggested that weight loss and regain, known as weight cycling, may result in greater body fatness and increased upper body fat distribution which may lead to adverse health consequences. These are concerns that may discourage some obese women from undergoing weight loss efforts. We retested 44 obese women, who took part in one of two weight control studies conducted in our laboratory, at either 6 or 12 months posttreatment. The followup study was performed to determine whether percent body fat and waist/hip ratio (WHR) had increased in those subjects who failed to maintain their weight loss. Subjects lost (mean + SD) 8.6 + 1.2 kg body weight, of which 7.0 + 1.0 kg was fat, and reduced their WHR by 0.03 + 0.006 (all p’s < .01) after either 12 or 16 weeks of treatment comprised of eating a low-fat diet, and in most cases performing endurance exercise training. At followup subjects were divided into groups based on the amount of weight regained. Those who regained (n=19) their lost weight were not fatter nor was their WHR higher than before the study began. These results do not support claims that weight cycling, in this case a single cycle, increases overall percentage of body fat or causes a redistribution of fat to the abdominal region of women.


2015 ◽  
Vol 77 (5) ◽  
pp. 710-718 ◽  
Author(s):  
Olta Gishti ◽  
Romy Gaillard ◽  
Busra Durmus ◽  
Marieke Abrahamse ◽  
Eline M. van der Beek ◽  
...  

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