E-science technologies in synchrotron radiation beamline — remote access and automation (A case study for high throughput protein crystallography)

2006 ◽  
Vol 14 (2) ◽  
pp. 140-145 ◽  
Author(s):  
Xiao Dong Wang ◽  
Michael Gleaves ◽  
David Meredith ◽  
Rob Allan ◽  
Colin Nave
Keyword(s):  
Synchrotron Radiation ◽  
High Throughput ◽  
Protein Crystallography ◽  
Remote Access

scholarly journals Principled Decision-Making Workflow with Hierarchical Bayesian Models of High-Throughput Dose-Response Measurements

Entropy ◽  
2021 ◽  
Vol 23 (6) ◽  
pp. 727
Author(s):  
Eric J. Ma ◽  
Arkadij Kummer
Keyword(s):  
Decision Making ◽  
High Throughput ◽  
Noisy Data ◽  
Hierarchical Bayesian ◽  
Hierarchical Bayesian Models ◽  
Melting Temperatures ◽  
Hierarchical Bayesian Estimation ◽  
The Face ◽  
Point Data

We present a case study applying hierarchical Bayesian estimation on high-throughput protein melting-point data measured across the tree of life. We show that the model is able to impute reasonable melting temperatures even in the face of unreasonably noisy data. Additionally, we demonstrate how to use the variance in melting-temperature posterior-distribution estimates to enable principled decision-making in common high-throughput measurement tasks, and contrast the decision-making workflow against simple maximum-likelihood curve-fitting. We conclude with a discussion of the relative merits of each workflow.

scholarly journals Action plan for hit identification (APHID): KAT6A as a case study

2020 ◽  
Vol 12 (5) ◽  
pp. 423-437 ◽  
Author(s):  
Xiangyan Yi ◽  
Lian Xue ◽  
Tim Thomas ◽  
Jonathan B Baell
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Action Plan ◽  
Hit Identification

Here, we describe our action plan for hit identification (APHID) that guides the process of hit triage, with elimination of less tractable hits and retention of more tractable hits. We exemplify the process with reference to our high-throughput screening (HTS) campaign against the enzyme, KAT6A, that resulted in successful identification of a tractable hit. We hope that APHID could serve as a useful, concise and digestible guide for those involved in HTS and hit triage, especially those that are relatively new to this exciting and continually evolving technology.

scholarly journals Modelling the Evolutionary Dynamics of Viruses within Their Hosts: A Case Study Using High-Throughput Sequencing

2012 ◽  
Vol 8 (4) ◽  
pp. e1002654 ◽  
Author(s):  
Frédéric Fabre ◽  
Josselin Montarry ◽  
Jérôme Coville ◽  
Rachid Senoussi ◽  
Vincent Simon ◽  
...  
Keyword(s):  
High Throughput ◽  
High Throughput Sequencing ◽  
Evolutionary Dynamics

The High-Throughput Synthesis and Phase Characterisation of Amphiphiles: A Sweet Case Study

2014 ◽  
Vol 20 (10) ◽  
pp. 2783-2792 ◽  
Author(s):  
George C. Feast ◽  
Oliver E. Hutt ◽  
Xavier Mulet ◽  
Charlotte E. Conn ◽  
Calum J. Drummond ◽  
...  
Keyword(s):  
High Throughput
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