Quantitative assessment of cerebral blood flow using Technetium-99m-hexamethyl-propyleneamine oxime: Part I, design of a mathematical model

1988 ◽  
Vol 2 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Hiroshi Matsuda ◽  
Hiroshi Oba ◽  
Hitoshi Terada ◽  
Shiro Tsuji ◽  
Hisashi Sumiya ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Quantitative Assessment ◽  
Technetium 99M

Interaction among autoregulation, CO2 reactivity, and intracranial pressure: a mathematical model

1998 ◽  
Vol 274 (5) ◽  
pp. H1715-H1728 ◽  
Author(s):  
Mauro Ursino ◽  
Carlo Alberto Lodi
Keyword(s):  
Mathematical Model ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Intracranial Pressure ◽  
Nonlinear Interaction ◽  
Cerebral Blood Volume ◽  
Cerebral Hemodynamics ◽  
Pial Arteries ◽  
Arterial Circulation ◽  
Neurosurgical Patients

The relationships among cerebral blood flow, cerebral blood volume, intracranial pressure (ICP), and the action of cerebrovascular regulatory mechanisms (autoregulation and CO2 reactivity) were investigated by means of a mathematical model. The model incorporates the cerebrospinal fluid (CSF) circulation, the intracranial pressure-volume relationship, and cerebral hemodynamics. The latter is based on the following main assumptions: the middle cerebral arteries behave passively following transmural pressure changes; the pial arterial circulation includes two segments (large and small pial arteries) subject to different autoregulation mechanisms; and the venous cerebrovascular bed behaves as a Starling resistor. A new aspect of the model exists in the description of CO2 reactivity in the pial arterial circulation and in the analysis of its nonlinear interaction with autoregulation. Simulation results, obtained at constant ICP using various combinations of mean arterial pressure and CO2 pressure, substantially support data on cerebral blood flow and velocity reported in the physiological literature concerning both the separate effects of CO2 and autoregulation and their nonlinear interaction. Simulations performed in dynamic conditions with varying ICP underline the existence of a significant correlation between ICP dynamics and cerebral hemodynamics in response to CO2 changes. This correlation may significantly increase in pathological subjects with poor intracranial compliance and reduced CSF outflow. In perspective, the model can be used to study ICP and blood velocity time patterns in neurosurgical patients in order to gain a deeper insight into the pathophysiological mechanisms leading to intracranial hypertension and secondary brain damage.

QUANTITATIVE ASSESSMENT OF REGIONAL CEREBRAL BLOOD FLOW WITH SPECT USING Tc99m-HMPAO: A COMPARISON TO CT AND MRI.

1987 ◽  
Vol 12 (Supplement) ◽  
pp. P10
Author(s):  
Karen Garret ◽  
John Kuperus ◽  
Aaron Peretz ◽  
Bruce Miller ◽  
Ismael G. Mena
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Quantitative Assessment ◽  
Regional Cerebral Blood ◽  
Ct And Mri

Interobserver variability of cerebral blood flow measurements obtained using spectral analysis and technetium-99m labeled compounds

2003 ◽  
Vol 17 (3) ◽  
pp. 255-259 ◽  
Author(s):  
Masashi Takasawa ◽  
Kenya Murase ◽  
Naohiko Oku ◽  
Minoru Kawamata ◽  
Makoto Nagayoshi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Spectral Analysis ◽  
Cerebral Blood Flow ◽  
Interobserver Variability ◽  
Labeled Compounds ◽  
Flow Measurements ◽  
Technetium 99M ◽  
Blood Flow Measurements
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