Biological effects of Tween-80 in combination with hyperthermia on human stomach cancer cell line BGC-823

1994 ◽  
Vol 6 (4) ◽  
pp. 252-258 ◽  
Author(s):  
Huchuan Yang ◽  
Yaoqin Yang ◽  
Huihong Tao ◽  
Junyi Zhou ◽  
Yongde Wang
Keyword(s):  
Cell Line ◽  
Stomach Cancer ◽  
Cancer Cell ◽  
Biological Effects ◽  
Cancer Cell Line ◽  
Tween 80 ◽  
Human Stomach ◽  
Human Stomach Cancer

scholarly journals A flavonoid compound fromChrysosplenium nudicauleinhibits growth and induces apoptosis of the human stomach cancer cell line SGC-7901

2015 ◽  
Vol 54 (7) ◽  
pp. 1133-1139 ◽  
Author(s):  
Yanping Luo ◽  
Hongjuan Yu ◽  
Yunshang Yang ◽  
Weihua Tian ◽  
Kaizhong Dong ◽  
...  
Keyword(s):  
Cell Line ◽  
Stomach Cancer ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Human Stomach ◽  
Flavonoid Compound ◽  
Human Stomach Cancer

scholarly journals The Anti-tumor Activity of Vitamin C via the Increase of Fas (CD95) and MHC I Expression on Human Stomach Cancer Cell Line, SNU1

2011 ◽  
Vol 11 (4) ◽  
pp. 210 ◽  
Author(s):  
Yeonsil Yu ◽  
Seyeon Bae ◽  
Hyemin Kim ◽  
Yejin Kim ◽  
Nag Bum Chu ◽  
...  
Keyword(s):  
Vitamin C ◽  
Cell Line ◽  
Stomach Cancer ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Human Stomach ◽  
Mhc I ◽  
Human Stomach Cancer ◽  
Anti Tumor Activity

New cancer cachexia rat model generated by implantation of a peritoneal dissemination-derived human stomach cancer cell line

2014 ◽  
Vol 306 (4) ◽  
pp. E373-E387 ◽  
Author(s):  
Kiyoshi Terawaki ◽  
Yumi Sawada ◽  
Yohei Kashiwase ◽  
Hirofumi Hashimoto ◽  
Mitsuhiro Yoshimura ◽  
...  
Keyword(s):  
Weight Loss ◽  
Cell Line ◽  
Stomach Cancer ◽  
Rat Model ◽  
Cancer Cachexia ◽  
Peritoneal Dissemination ◽  
Cancer Cell Line ◽  
Human Stomach ◽  
Mrna Levels ◽  
Human Stomach Cancer

Cancer cachexia (CC), a syndrome characterized by anorexia and body weight loss due to low fat-free mass levels, including reduced musculature, markedly worsens patient quality of life. Although stomach cancer patients have the highest incidence of cachexia, few experimental models for the study of stomach CC have been established. Herein, we developed stomach CC animal models using nude rats subcutaneously implanted with two novel cell lines, i.e., MKN45c185, established from the human stomach cancer cell line MKN-45, and 85As2, derived from peritoneal dissemination of orthotopically implanted MKN45c185 cells in mice. Both CC models showed marked weight loss, anorexia, reduced musculature and muscle strength, increased inflammatory markers, and low plasma albumin levels; however, CC developed earlier and was more severe in rats implanted with 85As2 than in those implanted with MKN45cl85. Moreover, human leukemia inhibitory factor (LIF), a known cachectic factor, and hypothalamic orexigenic peptide mRNA levels increased in the models, whereas hypothalamic anorexigenic peptide mRNA levels decreased. Surgical removal of the tumor not only abolished cachexia symptoms but also reduced plasma LIF levels to below detectable limits. Importantly, oral administration of rikkunshito, a traditional Japanese medicine, substantially ameliorated CC-related anorexia and body composition changes. In summary, our novel peritoneal dissemination-derived 85As2 rat model developed severe cachexia, possibly caused by LIF from cancer cells, that was ameliorated by rikkunshito. This model should provide a useful tool for further study into the mechanisms and treatment of stomach CC.

Effects of Sex Steroid Hormones on Corticosteroid-Binding Globulin Gene Expression in Human Endometrial Cancer Cell Line Ishikawa

1998 ◽  
Vol 35 (5) ◽  
pp. 637-642 ◽  
Author(s):  
Ryou Misao ◽  
Yoshihito Nakanishi ◽  
Jiro Fujimoto ◽  
Teruhiko Tamaya
Keyword(s):  
Endometrial Cancer ◽  
Mrna Expression ◽  
Cell Line ◽  
Cancer Cell ◽  
Biological Effects ◽  
Cancer Cell Line ◽  
High Dose ◽  
Dependent Manner ◽  
Endometrial Cancer Cell ◽  
Corticosteroid Binding Globulin

The effect of progestins on intracellular corticosteroid-binding globulin (CBG) mRNA expression in an endometrial cancer cell line (Ishikawa) was examined in an attempt to understand the biological effects of high-dose progestins in the treatment of well-differentiated uterine endometrial cancers. Oestradiol-17β (E2) significantly increased CBG mRNA expression in a dose-dependent manner, while a high dose of progesterone with or without E2 suppressed it significantly. Furthermore, a high dose of progesterone or medroxyprogesterone acetate (MPA) suppressed CBG mRNA expression to a greater degree than did chlormadinone acetate or 17 α-hydroxyprogesterone caproate with or without E2. These findings suggest that the effects of high-dose progestins on cancer cells may be mediated via suppression of intracellular CBG.

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