Detection of a coronary arterial thrombus by indium-111-oxine-labeled platelet scintigraphy

2001 ◽  
Vol 15 (1) ◽  
pp. 49-51 ◽  
Author(s):  
Keike Takahashi ◽  
Mitsumasa Ohyanagi ◽  
Jur Tateishi ◽  
Mihe Masai ◽  
Kiyomltsu Ikboka ◽  
...  
Keyword(s):  
Platelet Scintigraphy ◽  
Arterial Thrombus ◽  
Indium 111

Locating And Monitoring The Activity Of Intracardiac Thrombi With Indium-111 Platelet Scintigraphy

1981 ◽  
Author(s):  
M D Ezekowitz ◽  
E O Smith ◽  
A C Cox ◽  
S W Herren ◽  
F B Taylor
Keyword(s):  
Artery Bypass ◽  
Inhibitory Response ◽  
Left Ventricular ◽  
Platelet Recovery ◽  
Platelet Scintigraphy ◽  
Indium 111 ◽  
Induced Aggregation ◽  
Intracardiac Thrombi

Indium-III is 2.8 day half-life gamma emitting radionuclide which is suitable for scintigraphic study and has been used to label platelets without causing significant attenuation of function. The purpose of this study was to utilize this technique for localization of left ventricular mural thrombi in patients with regional LV dysfunction. The patient population consisted of 55 patients between the ages of 24 and 77 (53.4 ± 11.3, mean ± 1SD). Twenty-four required coronary artery bypass surgery with aneurysmectomy for intractable angina and/or heart failure. This provided an opportunity to validate the preoperative findings at surgery. Platelets were separated from 43 ml blood in ACD solution by centrifugation and were labelled in ACD:saline (1:7) solution at a pH of 6.5-7.0. A total of 3.8 ± 2.9 × 109 (mean ± 1SD) platelets labelled with 451.9 ± 111.6 μCi with a final labelling efficiency of 72.1±14.1% were injected IV. Platelet recovery at 15 minutes was 51.1 ± 17.7% (mean ± 1SD). EM studies before and after labelling showed no morphological change due to the labelling procedure. Aggregation of platelets in response to ADP and collagen was not altered significantly during the labelling process. Patients on aspirin showed the expected inhibitory effect of aspirin on collagen and ADP induced aggregation. Patients were imaged in multiple views on at least alternate days for a maximum of 8 days. Seventeen had positive studies. In those patients in which surgical confirmation of the scintigraphic studies was possible, a sensitivity of 72% and specificity of 100% was found. We conclude that: 1) Indium-111 platelet scintigraphy promises to be a reliable method of identifying intracardiac thrombi. 2) It may also be useful in monitoring thrombus activity in vivo. 3) Patients on aspirin incorporated platelets onto the thrombus surface in spite of showing the expected inhibitory response to ADP and collagen induced aggregation in vitro.

Indium-111 platelet scintigraphy in cerebrovascular disease

Neurology ◽  
1982 ◽  
Vol 32 (9) ◽  
pp. 938-938 ◽  
Author(s):  
W. J. Powers ◽  
B. A. Siegel ◽  
H. H. Davis ◽  
C. J. Mathias ◽  
H. B. Clark ◽  
...  
Keyword(s):  
Cerebrovascular Disease ◽  
Platelet Scintigraphy ◽  
Indium 111

Indium-111 labelled platelet scintigraphy can predict the immunological origin of fever in patients on dialysis carrying a non-functioning renal allograft

2000 ◽  
Vol 27 (3) ◽  
pp. 314-318 ◽  
Author(s):  
David Fuster ◽  
Francisco Lomeña ◽  
José V. Torregrosa ◽  
Federico Oppenheimer ◽  
Carlos Piera ◽  
...  
Keyword(s):  
Renal Allograft ◽  
Platelet Scintigraphy ◽  
Indium 111

Role of indium-111 labelled platelet scintigraphy in the management of thrombocytopenic patients with malignant neoplasms

1998 ◽  
Vol 25 (3) ◽  
pp. 247-252 ◽  
Author(s):  
Noboru Oriuchi ◽  
Meliha Korkmaz ◽  
E. Edmund Kim ◽  
Ebrahim S. Delpassand ◽  
Franklin Wong ◽  
...  
Keyword(s):  
Malignant Neoplasms ◽  
Platelet Scintigraphy ◽  
Indium 111

Evaluation of Thrombogenicity by Indium-111 Platelet Scintigraphy in Endografting for Abdominal Aortic Aneurysms

2006 ◽  
Vol 40 (5) ◽  
pp. 374-382 ◽  
Author(s):  
Taro Shimazaki ◽  
Satoshi Kawaguchi ◽  
Yoshihiko Yokoi ◽  
Susumu Makimura ◽  
Naozumi Saiki ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Platelet Scintigraphy ◽  
Abdominal Aortic ◽  
Indium 111

Diagnosis of a persistent pulmonary embolus by Indium-111 platelet scintigraphy with angiographic and tissue confirmation

1982 ◽  
Vol 72 (5) ◽  
pp. 839-842 ◽  
Author(s):  
Michael D. Ezekowitz ◽  
E.Randolph Eichner ◽  
Rick Scatterday ◽  
Ronald C. Elkins
Keyword(s):  
Pulmonary Embolus ◽  
Platelet Scintigraphy ◽  
Indium 111
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