Role of indium-111 labelled platelet scintigraphy in the management of thrombocytopenic patients with malignant neoplasms

1998 ◽  
Vol 25 (3) ◽  
pp. 247-252 ◽  
Author(s):  
Noboru Oriuchi ◽  
Meliha Korkmaz ◽  
E. Edmund Kim ◽  
Ebrahim S. Delpassand ◽  
Franklin Wong ◽  
...  
Keyword(s):  
Malignant Neoplasms ◽  
Platelet Scintigraphy ◽  
Indium 111

scholarly journals Integrative and Comprehensive Pancancer Analysis of Regulator of Chromatin Condensation 1 (RCC1)

2021 ◽  
Vol 22 (14) ◽  
pp. 7374
Author(s):  
Changwu Wu ◽  
Yingjuan Duan ◽  
Siming Gong ◽  
Sonja Kallendrusch ◽  
Nikolas Schopow ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Chromatin Condensation ◽  
Treatment Strategies ◽  
Enrichment Analysis ◽  
Tissue Expression ◽  
The Cancer Genome Atlas ◽  
Malignant Neoplasms ◽  
Nucleotide Exchange ◽  
Genome Database

Regulator of Chromatin Condensation 1 (RCC1) is the only known guanine nucleotide exchange factor that acts on the Ras-like G protein Ran and plays a key role in cell cycle regulation. Although there is growing evidence to support the relationship between RCC1 and cancer, detailed pancancer analyses have not yet been performed. In this genome database study, based on The Cancer Genome Atlas, Genotype-Tissue Expression and Gene Expression Omnibus databases, the potential role of RCC1 in 33 tumors’ entities was explored. The results show that RCC1 is highly expressed in most human malignant neoplasms in contrast to healthy tissues. RCC1 expression is closely related to the prognosis of a broad variety of tumor patients. Enrichment analysis showed that some tumor-related pathways such as “cell cycle” and “RNA transport” were involved in the functional mechanism of RCC1. In particular, the conducted analysis reveals the relation of RCC1 to multiple immune checkpoint genes and suggests that the regulation of RCC1 is closely related to tumor infiltration of cancer-associated fibroblasts and CD8+ T cells. Coherent data demonstrate the association of RCC1 with the tumor mutation burden and microsatellite instability in various tumors. These findings provide new insights into the role of RCC1 in oncogenesis and tumor immunology in various tumors and indicate its potential as marker for therapy prognosis and targeted treatment strategies.

scholarly journals Prognostic role of miR-9 expression in various human malignant neoplasms: a meta-analysis

2016 ◽  
pp. 3039 ◽  
Author(s):  
Ling Xu ◽  
Xiaodan Liu ◽  
Ziyan Luo ◽  
Hongxia Peng ◽  
Hua Jiang
Keyword(s):  
Meta Analysis ◽  
Malignant Neoplasms ◽  
Prognostic Role

scholarly journals Implementation of Mental adjustment to cancer scale in psycho-oncology practice in Bulgaria

2021 ◽  
Vol 31 (Supplement_3) ◽  
Author(s):  
S Tzvetkova ◽  
N Tschilingirova
Keyword(s):  
Disease Type ◽  
Malignant Neoplasms ◽  
Positive Relation ◽  
Cognitive Mechanisms ◽  
Mental Adjustment ◽  
Psychological Assistance ◽  
Oncology Practice ◽  
And Behavior ◽  
Personal Understanding

Abstract Background Theoretically there are several insufficiently confirmed statements based on evidences that underline the important role of psychological assistance to patients with malignant neoplasms. Since April, 2021, Mental Adjustment to Cancer Scale (MAC) is translated into Bulgarian and it was introduced to psycho-oncologic practice in Bulgaria. Methods The concise variant of MAC - Mini Mental Adjustment to Cancer Scale (Mini-MAC) has been implemented evaluating the degree when the patients perceive their adaptation to the diagnosis and cancer treatment. It comprises 29 items and measures four inner scales: determination, helplessness, anxiety, cognitive negligence and fatalism. It has been applied in compliance with strict confidentiality, voluntary principle and objectivity to 30 patients - 14 male and 16 female. Results MAC scales have good consistency - alpha coefficient from 0.56 to 0.74. The age correlates moderately with disease type (r=.35, p = 0.05). Helplessness is in positive relation to anxiety (r=.63, p = 0.000) and fatalism (r=.30, p = 0.05), and in negative one to determination (r=-.35, p = 0.05). The determination is in statistic positive relation to cognitive negligence (r=.44, p = 0.02). Conclusions The malignant disease type does not influence the scale results. They are influenced by inner factors as morbid experience, sensitivity to the disease, psychological protections that are frequently demonstrated by cognitive negligence and determination. MAC has been successfully implemented in the clinical psychological counseling in Bulgaria. Key messages Mental Adjustment to Cancer Scale identifies patients' adaptation to cancer and is introduced in Bulgaria. The methodology shows the established cognitive mechanisms for personal understanding and behavior in the course of treatment.

scholarly journals Ursodeoxycholic acid and cancer prevention

2019 ◽  
pp. 39-43 ◽  
Author(s):  
A. R. Reyzis
Keyword(s):  
Cancer Prevention ◽  
Ursodeoxycholic Acid ◽  
Acid Metabolism ◽  
Surgical Care ◽  
Bile Acid Metabolism ◽  
Malignant Neoplasms ◽  
Rational Treatment ◽  
Great Progress ◽  
Prevention Of Cancer

 Along with the great progress in the fight against malignant neoplasms through the improvement of surgical care and the development of chemotherapy, the search for strategies and opportunities to prevent cancer is becoming increasingly important and promising. Early detection and rational treatment of chronic precancerous diseases must be a priority. In this regard, the possible role of ursodeoxycholic acid (UDCA, ursosan, etc.) has been closely studied in recent years. An overview of the role of ursodeoxycholic acid (UDCA) in the prevention of cancer is presented. The pathogenetic basis of this action is the proven normalizing effect of UDCA on bile acid metabolism, microbiome condition and apoptosis. The paper summarizes the latest data on the ability of UDCA to withstand malignization in the liver, throughout the gastrointestinal tract and beyond. These numerous experimental and clinical studies allow us to assert that UDCA drugs, except for the well-known and versatile hepatoprotective effect, can be considered as effective and promising means of cancer prevention throughout the digestive tract and associated organs. Further research into the broad spectrum of UDCA’s ability to prevent gastrointestinal malignization and beyond is reasonable and promising.

scholarly journals Role of biomarkers in predicting the occurrence of thyroid neoplasms in radiation-exposed children

2018 ◽  
Vol 25 (4) ◽  
pp. 481-491
Author(s):  
Joseph M Shulan ◽  
Leonid Vydro ◽  
Arthur B Schneider ◽  
Dan V Mihailescu
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Nodules ◽  
Subsequent Development ◽  
Thyroid Neoplasms ◽  
Childhood Cancer Survivors ◽  
Malignant Neoplasms ◽  
Increased Risk ◽  
Need To Evaluate

With increasing numbers of childhood cancer survivors who were treated with radiation, there is a need to evaluate potential biomarkers that could signal an increased risk of developing thyroid cancer. We aimed to examine the relationships between thyrotropin and thyroglobulin levels and the risk of developing thyroid nodules and cancer in a cohort of radiation-exposed children. 764 subjects who were irradiated in the neck area as children were examined and followed for up to 25 years. All subjects underwent a clinical examination, measurements of thyrotropin, thyroglobulin levels and thyroid imaging. At baseline, 216 subjects had thyroid nodules and 548 did not. Of those with nodules, 176 underwent surgery with 55 confirmed thyroid cancers. During the follow-up, 147 subjects developed thyroid nodules including 22 with thyroid cancer. Thyroglobulin levels were higher in subjects with prevalent thyroid nodules (26.1 ng/mL vs 9.37 ng/mL; P < 0.001) and in those who had an initial normal examination but later developed thyroid nodules (11.2 ng/mL vs 8.87 ng/mL; P = 0.017). There was no relationship between baseline thyrotropin levels and the prevalent presence or absence of thyroid nodules, whether a prevalent neoplasm was benign or malignant, subsequent development of thyroid nodules during follow-up or whether an incident nodule was benign or malignant. In conclusion, in radiation-exposed children, higher thyroglobulin levels indicated an increased risk of developing thyroid nodules but did not differentiate between benign and malignant neoplasms. There was no association between the baseline TSH level and the risk of developing thyroid nodules or cancer.

Locating And Monitoring The Activity Of Intracardiac Thrombi With Indium-111 Platelet Scintigraphy

1981 ◽  
Author(s):  
M D Ezekowitz ◽  
E O Smith ◽  
A C Cox ◽  
S W Herren ◽  
F B Taylor
Keyword(s):  
Artery Bypass ◽  
Inhibitory Response ◽  
Left Ventricular ◽  
Platelet Recovery ◽  
Platelet Scintigraphy ◽  
Indium 111 ◽  
Induced Aggregation ◽  
Intracardiac Thrombi

Indium-III is 2.8 day half-life gamma emitting radionuclide which is suitable for scintigraphic study and has been used to label platelets without causing significant attenuation of function. The purpose of this study was to utilize this technique for localization of left ventricular mural thrombi in patients with regional LV dysfunction. The patient population consisted of 55 patients between the ages of 24 and 77 (53.4 ± 11.3, mean ± 1SD). Twenty-four required coronary artery bypass surgery with aneurysmectomy for intractable angina and/or heart failure. This provided an opportunity to validate the preoperative findings at surgery. Platelets were separated from 43 ml blood in ACD solution by centrifugation and were labelled in ACD:saline (1:7) solution at a pH of 6.5-7.0. A total of 3.8 ± 2.9 × 109 (mean ± 1SD) platelets labelled with 451.9 ± 111.6 μCi with a final labelling efficiency of 72.1±14.1% were injected IV. Platelet recovery at 15 minutes was 51.1 ± 17.7% (mean ± 1SD). EM studies before and after labelling showed no morphological change due to the labelling procedure. Aggregation of platelets in response to ADP and collagen was not altered significantly during the labelling process. Patients on aspirin showed the expected inhibitory effect of aspirin on collagen and ADP induced aggregation. Patients were imaged in multiple views on at least alternate days for a maximum of 8 days. Seventeen had positive studies. In those patients in which surgical confirmation of the scintigraphic studies was possible, a sensitivity of 72% and specificity of 100% was found. We conclude that: 1) Indium-111 platelet scintigraphy promises to be a reliable method of identifying intracardiac thrombi. 2) It may also be useful in monitoring thrombus activity in vivo. 3) Patients on aspirin incorporated platelets onto the thrombus surface in spite of showing the expected inhibitory response to ADP and collagen induced aggregation in vitro.

scholarly journals About the role of environmental factors in carcinogenesis

2020 ◽  
Vol 169 ◽  
pp. 04003
Author(s):  
Sergey K. Pinaev ◽  
Olga G. Pinaeva ◽  
Alexey Ya. Chizhov
Keyword(s):  
Oxidative Stress ◽  
Environmental Factors ◽  
Young Children ◽  
Forest Fires ◽  
Malignant Neoplasms ◽  
The Sun ◽  
Child Population

There were found out the connections of the activity of the Sun and smoke of forest fires with the incidence of various forms of benign and malignant neoplasms in the population of young children 0-4 years old, in Khabarovsk Region, Russia. Thus, it was determined that so-called “sporadic” fluctuations in the incidence of neoplasms in the child population are not random. They are caused by long multi-year cycles of changes in the complex of environmental factors. The authors identified this phenomenon as “Alternative oncogenesis”, meaning by it the predominant occurrence of various forms of neoplasms in a certain period of time due to a change in the parameters of the complex of environmental factors. A proposed hypothesis is: ecologically linked oxidative stress as a cause of the epigenomic modulation leading to an imbalance between semaphorins and integrins that brings to oncogenesis.

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