Long-Term conditioned fear modification in the dog as measured by changes in urinary 11-hydroxycorticosteroids. Heart rate and behavior

1974 ◽  
Vol 9 (2) ◽  
pp. 85-96
Author(s):  
Vincent P. Houser ◽  
William P. Pabé
Keyword(s):  
Heart Rate ◽  
Conditioned Fear ◽  
And Behavior

scholarly journals Functions of Gtf2i and Gtf2ird1 in the developing brain: transcription, DNA-binding, and long term behavioral consequences

2019 ◽  
Author(s):  
Nathan D. Kopp ◽  
Kayla R. Nygaard ◽  
Katherine B. McCullough ◽  
Susan E. Maloney ◽  
Harrison W. Gabel ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Sites ◽  
Conditioned Fear ◽  
Developing Brain ◽  
Ctcf Binding ◽  
Microdeletion Syndrome ◽  
Behavioral Phenotypes ◽  
Marble Burying ◽  
And Behavior

AbstractGtf2ird1 and Gtf2i may mediate aspects of the cognitive and behavioral phenotypes of Williams Syndrome (WS) – a microdeletion syndrome encompassing these transcription factors (TFs). Knockout mouse models of each TF show behavioral phenotypes. Here we identify their genomic binding sites in the developing brain, and test for additive effects of their mutation on transcription and behavior. Both TFs target constrained chromatin modifier and synaptic protein genes, including a significant number of ASD genes. They bind promoters, strongly overlap CTCF binding and TAD boundaries, and moderately overlap each other, suggesting epistatic effects. We used single and double mutants to test whether mutating both TFs will modify transcriptional and behavioral phenotypes of single Gtf2ird1 mutants. Despite little difference in DNA-binding and transcriptome-wide expression, Gtf2ird1 mutation caused balance, marble burying, and conditioned fear phenotypes. However, mutating Gtf2i in addition to Gtf2ird1 did not further modify transcriptomic or most behavioral phenotypes, suggesting Gtf2ird1 mutation alone is sufficient.

Effect of heart rate on long-term mortality among men and women

2007 ◽  
Vol 62 (3) ◽  
pp. 271-275 ◽  
Author(s):  
H. THEOBALD ◽  
P.E. WÄNDELL
Keyword(s):  
Heart Rate ◽  
Men And Women ◽  
Long Term Mortality

Long Term Effects of Low Frequency (10 Hz) Vagus Nerve Stimulation on EEG and Heart Rate Variability in Crohn's Disease: A Case Report

2014 ◽  
Vol 7 (6) ◽  
pp. 914-916 ◽  
Author(s):  
Didier Clarençon ◽  
Sonia Pellissier ◽  
Valérie Sinniger ◽  
Astrid Kibleur ◽  
Dominique Hoffman ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Crohn’S Disease ◽  
Case Report ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Low Frequency ◽  
Long Term Effects

scholarly journals Monitoring Training and Recovery during a Period of Increased Intensity or Volume in Recreational Endurance Athletes

2021 ◽  
Vol 18 (5) ◽  
pp. 2401
Author(s):  
Olli-Pekka Nuuttila ◽  
Ari Nummela ◽  
Keijo Häkkinen ◽  
Santtu Seipäjärvi ◽  
Heikki Kyröläinen
Keyword(s):  
Heart Rate ◽  
Control Period ◽  
Endurance Performance ◽  
Training Period ◽  
Training Intensity ◽  
Countermovement Jump ◽  
Maximal Speed ◽  
Individualized Approach ◽  
Monitoring Training

The purpose of the study was to examine the effects of progressively increased training intensity or volume on the nocturnal heart rate (HR) and heart rate variability (HRV), countermovement jump, perceived recovery, and heart rate-running speed index (HR-RS index). Another aim was to analyze how observed patterns during the training period in these monitoring variables were associated with the changes in endurance performance. Thirty recreationally trained participants performed a 10-week control period of regular training and a 10-week training period of either increased training intensity (INT, n = 13) or volume (VOL, n = 17). Changes in endurance performance were assessed by an incremental treadmill test. Both groups improved their maximal speed on the treadmill (INT 3.4 ± 3.2%, p < 0.001; VOL 2.1 ± 1.8%, p = 0.006). In the monitoring variables, only between-group difference (p = 0.013) was found in nocturnal HR, which decreased in INT (p = 0.016). In addition, perceived recovery decreased in VOL (p = 0.021) and tended to decrease in INT (p = 0.056). When all participants were divided into low-responders and responders in maximal running performance, the increase in the HR-RS index at the end of the training period was greater in responders (p = 0.005). In conclusion, current training periods of increased intensity or volume improved endurance performance to a similar extent. Countermovement jump and HRV remained unaffected, despite a slight decrease in perceived recovery. Long-term monitoring of the HR-RS index may help to predict positive adaptations, while interpretation of other recovery-related markers may need a more individualized approach.

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