Therapeutic efficacy of DNA-Loaded PLGA microspheres in tumor-bearing mice

2007 ◽  
Vol 30 (8) ◽  
pp. 1047-1050 ◽  
Author(s):  
Hye-Jung Son ◽  
Jin-Seok Kim
Keyword(s):  
Therapeutic Efficacy ◽  
Plga Microspheres ◽  
Tumor Bearing

scholarly journals A Novel Paclitaxel Microemulsion Containing a Reduced Amount of Cremophor EL: Pharmacokinetics, Biodistribution, andIn VivoAntitumor Efficacy and Safety

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Ying Wang ◽  
Ke-Chun Wu ◽  
Bing-Xiang Zhao ◽  
Xin Zhao ◽  
Xin Wang ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Therapeutic Efficacy ◽  
Antitumor Efficacy ◽  
Allergic Reactions ◽  
Cremophor El ◽  
Efficacy And Safety ◽  
Tumor Bearing ◽  
Allergic Effect ◽  
Injection Product

The purpose of this study was to prepare a novel paclitaxel (PTX) microemulsion containing a reduced amount of Cremophor EL (CrEL) which had similar pharmacokinetics and antitumor efficacy as the commercially available PTX injection, but a significantly reduced allergic effect due to the CrEL. The pharmacokinetics, biodistribution,in vivoantitumor activity and safety of PTX microemulsion was evaluated. The results of pharmacokinetic and distribution properties of PTX in the microemulsion were similar to those of the PTX injection. The antitumor efficacy of the PTX microemulsion in OVCRA-3 and A 549 tumor-bearing animals was similar to that of PTX injection. The PTX microemulsion did not cause haemolysis, erythrocyte agglutination or simulative reaction. The incidence and degree of allergic reactions exhibited by the PTX microemulsion group, with or without premedication, were significantly lower than those in the PTX injection group (P<.01). In conclusion, the PTX microemulsion had similar pharmacokinetics and anti-tumor efficacy to the PTX injection, but a significantly reduced allergic effect due to CrEL, indicating that the PTX microemulsion overcomes the disadvantages of the conventional PTX injection and is one way of avoiding the limitations of current injection product while providing suitable therapeutic efficacy.

scholarly journals 177Lu-Labeled Phosphoramidate-Based PSMA Inhibitors: The Effect of an Albumin Binder on Biodistribution and Therapeutic Efficacy in Prostate Tumor-Bearing Mice

Theranostics ◽  
2017 ◽  
Vol 7 (7) ◽  
pp. 1928-1939 ◽  
Author(s):  
Cindy J. Choy ◽  
Xiaoxi Ling ◽  
Jonathan J. Geruntho ◽  
Sophia K. Beyer ◽  
Joseph D. Latoche ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Prostate Tumor ◽  
Tumor Bearing

Self-targeted, bacillus-shaped, and controlled-release methotrexate prodrug polymeric nanoparticles for intratumoral administration with improved therapeutic efficacy in tumor-bearing mice

2015 ◽  
Vol 3 (39) ◽  
pp. 7707-7717 ◽  
Author(s):  
Jinyan Lin ◽  
Yanxiu Li ◽  
Yang Li ◽  
Fei Cui ◽  
Fei Yu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Cancer Chemotherapy ◽  
Therapeutic Efficacy ◽  
Polymeric Nanoparticles ◽  
Intratumoral Administration ◽  
Tumor Bearing ◽  
Highly Efficient

Self-targeted, bacillus-shaped, and controlled-release methotrexate prodrug polymeric nanoparticles for highly efficient cancer chemotherapy: more elongated is better.

scholarly journals Molecular imaging and therapeutic efficacy of 188Re-(DXR)-liposome-BBN in AR42J pancreatic tumor-bearing mice

2012 ◽  
Vol 28 (5) ◽  
pp. 1736-1742 ◽  
Author(s):  
YA-JEN CHANG ◽  
CHIA-YU YU ◽  
CHIN-WEI HSU ◽  
WAN-CHI LEE ◽  
SU-JUNG CHEN ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Therapeutic Efficacy ◽  
Pancreatic Tumor ◽  
Tumor Bearing

Approaches to Improve Therapeutic Efficacy of Biodegradable PLA/PLGA Microspheres: A Review

2018 ◽  
Vol 58 (3) ◽  
pp. 495-536 ◽  
Author(s):  
Soo-Ling Bee ◽  
Z. A. Abdul Hamid ◽  
M. Mariatti ◽  
B. H. Yahaya ◽  
Keemi Lim ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Plga Microspheres

Tumor specificity and therapeutic efficacy of photosensitizer-encapsulated glycol chitosan-based nanoparticles in tumor-bearing mice

Biomaterials ◽  
2009 ◽  
Vol 30 (15) ◽  
pp. 2929-2939 ◽  
Author(s):  
So Jin Lee ◽  
Kyeongsoon Park ◽  
Yu-Kyoung Oh ◽  
Seung-Hae Kwon ◽  
Songwook Her ◽  
...  
Keyword(s):  
Therapeutic Efficacy ◽  
Glycol Chitosan ◽  
Tumor Bearing ◽  
Tumor Specificity

Therapeutic Efficacy and Radiobiological Effects of Boric Acid-mediated BNCT in a VX2 Multifocal Liver Tumor-bearing Rabbit Model

2019 ◽  
Vol 39 (10) ◽  
pp. 5495-5504
Author(s):  
YI-HSUAN HUNG ◽  
YU-CHUAN LIN ◽  
YU-TING LIN ◽  
GUAN-WEN SHIH ◽  
JIUNN-WANG LIAO ◽  
...  
Keyword(s):  
Boric Acid ◽  
Liver Tumor ◽  
Therapeutic Efficacy ◽  
Rabbit Model ◽  
Tumor Bearing ◽  
Radiobiological Effects

scholarly journals Co-Encapsulation of Chlorin e6 and Chemotherapeutic Drugs in a PEGylated Liposome Enhance the Efficacy of Tumor Treatment: Pharmacokinetics and Therapeutic Efficacy

Pharmaceutics ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 617 ◽  
Author(s):  
Po-Chun Peng ◽  
Ruey-Long Hong ◽  
Tsuimin Tsai ◽  
Chin-Tin Chen
Keyword(s):  
Therapeutic Efficacy ◽  
Light Irradiation ◽  
Chlorin E6 ◽  
Tumor Treatment ◽  
Drug Bioavailability ◽  
Dual Effect ◽  
Tumor Bearing ◽  
Therapeutic Outcomes ◽  
Significant Survival ◽  
Pharmacokinetic Properties

Long-circulating PEG-modified liposome has been shown to improve pharmacokinetic properties and reduce systemic toxicity in cancer treatment. However, drug bioavailability from liposome remains a major challenge to the improvement of its therapeutic efficacy. Previously, we designed a PEGylated dual-effect liposome (named as PL-Dox-Ce6) with chlorin e6 incorporated in the lipid bilayer and Doxorubicin encapsulated in the interior. In this study, another dual-effect liposome with cisplatin encapsulated in the interior was further developed. The pharmacokinetics of these two dual-effect liposomes were studied in tumor-bearing mice. Based on the kinetic data of tumor and plasma, light irradiation was applied onto the tumors at different time points after drug administration to compare the therapeutic efficacy. We demonstrated that a single dose of the dual-effect liposomes combined with two doses of light irradiation can completely eradicate over 90% of the tumor in mice alone with significant survival rate and no toxicity. Thus, this study established a platform that utilizes the dual-effect liposome which combines photodynamic therapy and chemotherapy to improve the therapeutic outcomes of tumors.

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