Superimposed dual-isotope SPECT using99mTc-hydroxymethylene diphosphonate and201Tl-chloride to assess cartilage invasion in laryngohypopharyngeal cancer

2004 ◽  
Vol 18 (6) ◽  
pp. 527-532 ◽  
Author(s):  
Yoshihiro Nishiyama ◽  
Yuka Yamamoto ◽  
Koiku Yokoe ◽  
Kazunori Miyabe ◽  
Takanobu Iwasaki ◽  
...  
Keyword(s):  
Dual Isotope ◽  
Cartilage Invasion ◽  
Laryngohypopharyngeal Cancer

Dual-isotope single-photon emission computerized tomography scanning in patients with glioblastoma multiforme: association with patient survival and histopathological characteristics of tumor after high-dose radiotherapy

1998 ◽  
Vol 89 (1) ◽  
pp. 60-68 ◽  
Author(s):  
Richard B. Schwartz ◽  
B. Leonard Holman ◽  
Joseph F. Polak ◽  
Basem M. Garada ◽  
Marc S. Schwartz ◽  
...  
Keyword(s):  
Survival Rate ◽  
Glioblastoma Multiforme ◽  
Single Photon ◽  
Photon Emission ◽  
High Dose ◽  
Term Survival ◽  
Content Type ◽  
Dual Isotope ◽  
Fine Print

Object. The study was conducted to determine the association between dual-isotope single-photon emission computerized tomography (SPECT) scanning and histopathological findings of tumor recurrence and survival in patients treated with high-dose radiotherapy for glioblastoma multiforme. Methods. Studies in which SPECT with 201Tl and 99mTc-hexamethypropyleneamine oxime (HMPAO) were used were performed 1 day before reoperation in 47 patients with glioblastoma multiforme who had previously been treated by surgery and high-dose radiotherapy. Maximum uptake of 201Tl in the lesion was expressed as a ratio to that in the contralateral scalp, and uptake of 99mTc-HMPAO was expressed as a ratio to that in the cerebellar cortex. Patients were stratified into groups based on the maximum radioisotope uptake values in their tumor beds. The significance of differences in patient gender, histological characteristics of tissue at reoperation, and SPECT uptake group with respect to 1-year survival was elucidated by using the chi-square statistic. Comparisons of patient ages and time to tumor recurrence as functions of 1-year survival were made using the t-test. Survival data at 1 year were presented according to the Kaplan—Meier method, and the significance of potential differences was evaluated using the log-rank method. The effects of different variables (tumor type, time to recurrence, and SPECT grouping) on long-term survival were evaluated using Cox proportional models that controlled for age and gender. All patients in Group I (201Tl ratio < 2 and 99mTc-HMPAO ratio < 0.5) showed radiation changes in their biopsy specimens: they had an 83.3% 1-year survival rate. Group II patients (201T1 ratio < 2 and 99mTc-HMPAO ratio of ≥ 0.5 or 201Tl ratio between 2 and 3.5 regardless of 99mTc-HMPAO ratio) had predominantly infiltrating tumor (66.6%); they had a 29.2% 1-year survival rate. Almost all of the patients in Group III (201Tl ratio > 3.5 and 99mTc-HMPAO ratio ≥ 0.5) had solid tumor (88.2%) and they had a 6.7% 1-year survival rate. Histological data were associated with 1-year survival (p < 0.01); however, SPECT grouping was more closely associated with 1-year survival (p < 0.001) and was the only variable significantly associated with long-term survival (p < 0.005). Conclusions. Dual-isotope SPECT data correlate with histopathological findings made at reoperation and with survival in patients with malignant gliomas after surgical and high-dose radiation therapy.

scholarly journals A dual-isotope-labeling method of studying the bioavailability of hexaglutamyl folic acid relative to that of monoglutamyl folic acid in humans by using multiple orally administered low doses

2006 ◽  
Vol 84 (5) ◽  
pp. 1128-1133 ◽  
Author(s):  
Alida Melse-Boonstra ◽  
Petra Verhoef ◽  
Clive E West ◽  
Johannes A van Rhijn ◽  
Richard B van Breemen ◽  
...  
Keyword(s):  
Folic Acid ◽  
Isotope Labeling ◽  
Low Doses ◽  
Dual Isotope ◽  
Labeling Method

scholarly journals Simultaneous Visualization of 161Tb- and 177Lu-Labeled Somatostatin Analogues Using Dual-Isotope SPECT Imaging

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 536
Author(s):  
Francesca Borgna ◽  
Patrick Barritt ◽  
Pascal V. Grundler ◽  
Zeynep Talip ◽  
Susan Cohrs ◽  
...  
Keyword(s):  
Pharmacokinetic Profile ◽  
Somatostatin Analogues ◽  
Distribution Coefficients ◽  
Spect Imaging ◽  
Cell Uptake ◽  
Organ Distribution ◽  
Dual Isotope ◽  
Biodistribution Studies ◽  
Simultaneous Visualization

The decay of terbium-161 results in the emission of β¯-particles as well as conversion and Auger electrons, which makes terbium-161 interesting for therapeutic purposes. The aim of this study was to use dual-isotope SPECT imaging in order to demonstrate visually that terbium-161 and lutetium-177 are interchangeable without compromising the pharmacokinetic profile of the radiopharmaceutical. The 161Tb- and 177Lu-labeled somatostatin (SST) analogues DOTATOC (agonist) and DOTA-LM3 (antagonist) were tested in vitro to demonstrate equal properties regarding distribution coefficients and cell uptake into SST receptor-positive AR42J tumor cells. The radiopeptides were further investigated in AR42J tumor-bearing nude mice using the method of dual-isotope (terbium-161/lutetium-177) SPECT/CT imaging to enable the visualization of their distribution profiles in the same animal. Equal pharmacokinetic profiles were demonstrated for either of the two peptides, irrespective of whether it was labeled with terbium-161 or lutetium-177. Moreover, the visualization of the sub-organ distribution confirmed similar behavior of 161Tb- and 177Lu-labeled SST analogues. The data were verified in quantitative biodistribution studies using either type of peptide labeled with terbium-161 or lutetium-177. While the radionuclide did not have an impact on the organ distribution, this study confirmed previous data of a considerably higher tumor uptake of radiolabeled DOTA-LM3 as compared to the radiolabeled DOTATOC.

scholarly journals New Perspectives on Migration into the Tlajinga District of Teotihuacan: A Dual-Isotope Approach

2021 ◽  
pp. 1-21
Author(s):  
Gina M. Buckley ◽  
Rebecca Storey ◽  
Fred J. Longstaffe ◽  
David M. Carballo ◽  
Kenneth G. Hirth ◽  
...  
Keyword(s):  
Oxygen Isotopes ◽  
Human Remains ◽  
Past Research ◽  
Urban Center ◽  
Radiocarbon Dates ◽  
Future Studies ◽  
Dual Isotope ◽  
West Mexico ◽  
New Finding ◽  
The City

The city of Teotihuacan (AD 1–550) was a major multiethnic urban center that attracted migrants from as far away as west Mexico and the Maya region. Past research in the Tlajinga district at Teotihuacan using oxygen isotopes from human remains estimated that nearly 30% of the population of Tlajinga 33, a single apartment compound, were migrants. This study takes a dual-isotope approach (87Sr/86Sr and δ18O p ) to reevaluate the proportion of in-migration at Tlajinga and includes data from two additional apartment compounds, Tlajinga 17 and 18 (n = 23). New results indicate that migrants comprised ~45% of the Tlajinga population. Previously acquired radiocarbon dates combined with mortuary and isotope data suggest that immigration to Tlajinga was highest during the first centuries of compound occupation. Nevertheless, migration was a continual process throughout its history. Additionally, a new finding suggests that residents of Tlajinga 33 ingested foods with higher 87Sr/86Sr ratios than did those of Tlajinga 17 and 18. We hypothesize that the incorporation of imported lime for the nixtamalization process skewed the 87Sr/86Sr ratios of human remains, a potentially important finding for future studies at Teotihuacan.

Individual-Specific Transgenerational Marking of Fish Populations Based on a Barium Dual-Isotope Procedure

2011 ◽  
Vol 84 (1) ◽  
pp. 127-133 ◽  
Author(s):  
Gonzalo Huelga-Suarez ◽  
Mariella Moldovan ◽  
America Garcia-Valiente ◽  
Eva Garcia-Vazquez ◽  
J. Ignacio Garcia Alonso
Keyword(s):  
Fish Populations ◽  
Dual Isotope

Invasiveness of synovial fibroblasts is regulated by p53 in the SCID mouse in vivo model of cartilage invasion

2001 ◽  
Vol 44 (3) ◽  
pp. 676-681 ◽  
Author(s):  
Thomas Pap ◽  
Karlfried R. Aupperle ◽  
Steffen Gay ◽  
Gary S. Firestein ◽  
Renate E. Gay
Keyword(s):  
Scid Mouse ◽  
Synovial Fibroblasts ◽  
In Vivo Model ◽  
Cartilage Invasion
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