Isoflavonoids from the rhizomes ofBelamcanda chinensis and their effects on aldose reductase and sorbitol accumulation in streptozotocin induced diabetic rat tissues

2002 ◽  
Vol 25 (3) ◽  
pp. 306-312 ◽  
Author(s):  
Sang Hoon Jung ◽  
Yeon Sil Lee ◽  
Sanghyun Lee ◽  
Soon Sung Lim ◽  
Yeong Shik Kim ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Diabetic Rat ◽  
Rat Tissues

Inhibitory effects ofGanoderma applanatum on rat lens aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues

2005 ◽  
Vol 19 (6) ◽  
pp. 477-480 ◽  
Author(s):  
Sang Hoon Jung ◽  
Yeon Sil Lee ◽  
Sang Hee Shim ◽  
Sanghyun Lee ◽  
Kuk Hyun Shin ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Diabetic Rat ◽  
Rat Tissues ◽  
Inhibitory Effects ◽  
Rat Lens Aldose Reductase

Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues

2001 ◽  
Vol 53 (5) ◽  
pp. 653-668 ◽  
Author(s):  
Soon Sung Lim ◽  
Sang Hoon Jung ◽  
Jun Ji ◽  
Kuk Hyun Shin ◽  
Sam Rok Keum
Keyword(s):  
Aldose Reductase ◽  
Diabetic Rat ◽  
Rat Tissues

Aldose Reductase Inhibition and thePhosphorus-31 Profile of the Intact Diabetic Rat Lens

1993 ◽  
Vol 25 (6) ◽  
pp. 393-399 ◽  
Author(s):  
Kazuo Tsubota ◽  
Masaaki Yoshida ◽  
Takashi Toda ◽  
Masafumi Ono ◽  
Kazuto Kajiwara ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Diabetic Rat ◽  
Aldose Reductase Inhibition

Aldose Reductase Inhibitor Fidarestat Attenuates Leukocyte-Endothelial Interactions in Experimental Diabetic Rat RetinaIn Vivo

2010 ◽  
Vol 35 (2) ◽  
pp. 146-154 ◽  
Author(s):  
Tomoaki Hattori ◽  
Akihisa Matsubara ◽  
Kaori Taniguchi ◽  
Yuichiro Ogura
Keyword(s):  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Diabetic Rat

scholarly journals Alterations in Energy Metabolism, Mitochondrial Function and Redox Homeostasis in GK Diabetic Rat Tissues Treated with Aspirin

Life ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 104
Author(s):  
Annie John ◽  
Layla Amiri ◽  
Jasmin Shafarin ◽  
Saeed Tariq ◽  
Ernest Adeghate ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Energy Metabolism ◽  
Mitochondrial Function ◽  
Redox Homeostasis ◽  
Diabetic Rats ◽  
Endocrine Function ◽  
Diabetic Rat ◽  
Rat Tissues ◽  
Gk Rats ◽  
And Oxidative Stress

Our recent studies have demonstrated that aspirin treatment prevents inflammatory and oxidative stress-induced alterations in mitochondrial function, improves glucose tolerance and pancreatic endocrine function and preserves tissue-specific glutathione (GSH)-dependent redox homeostasis in Goto-Kakizaki (GK) diabetic rats. In the current study, we have investigated the mechanism of action of aspirin in maintaining mitochondrial bioenergetics and redox metabolism in the liver and kidneys of GK rats. Aspirin reduced the production of reactive oxygen species (ROS) and oxidative stress-induced changes in GSH metabolism. Aspirin treatment also improved mitochondrial respiratory function and energy metabolism, in addition to regulating the expression of cell signaling proteins that were altered in diabetic animals. Ultrastructural electron microscopy studies revealed decreased accumulation of glycogen in the liver of aspirin-treated diabetic rats. Hypertrophic podocytes with irregular fusion of foot processes in the renal glomerulus and detached microvilli, condensed nuclei and degenerated mitochondria observed in the proximal convoluted tubules of GK rats were partially restored by aspirin. These results provide additional evidence to support our previous observation of moderation of diabetic complications by aspirin treatment in GK rats and may have implications for cautious use of aspirin in the therapeutic management of diabetes.

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