Aldose Reductase Inhibitor Fidarestat Attenuates Leukocyte-Endothelial Interactions in Experimental Diabetic Rat RetinaIn Vivo

2010 ◽  
Vol 35 (2) ◽  
pp. 146-154 ◽  
Author(s):  
Tomoaki Hattori ◽  
Akihisa Matsubara ◽  
Kaori Taniguchi ◽  
Yuichiro Ogura
Keyword(s):  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Diabetic Rat

Permeability changes at blood-retinal barrier in diabetes and effect of aldose reductase inhibition

1990 ◽  
Vol 259 (3) ◽  
pp. R601-R605
Author(s):  
S. Lightman ◽  
G. Pinter ◽  
L. Yuen ◽  
M. Bradbury
Keyword(s):  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Concomitant Administration ◽  
Aldose Reductase Inhibitor ◽  
Normal Diet ◽  
Diabetic Rat ◽  
Blood Retinal Barrier ◽  
Time Points ◽  
Permeability Changes

Sensitive quantitative in vivo techniques were used to assess the permeability at the blood-retinal barrier (BRB) to [14C]sucrose in the anesthetized streptozocin-diabetic rat at various time points (3 wk, 6 mo, 13 mo) after induction of diabetes. The effects of concomitant administration of an aldose reductase inhibitor (ARI) on sorbitol levels in the retina and on BRB permeability were also measured. No increase in BRB permeability was found in rats diabetic for 3 wk or 6 mo, but after 13 mo of hyperglycemia there was an increase in permeability of 240%. No effect on permeability was seen in diabetic animals given the ARI despite the retinal sorbitol levels being decreased in the treated compared with the untreated diabetic group fed a normal diet. This study suggests that the accumulation of sorbitol within the cells of the BRB is not responsible for the breakdown of BRB permeability seen after 7-13 mo of hyperglycemia and that the enzyme aldose reductase is not involved in its pathogenesis.

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