A synthetic study on cyclic phosphate derivatives of seconucleosides as potential antiviral agents (II): Synthesis of 3′, 5′-cyclic phosphates of 6-aza-2′-azido-secouridine

1992 ◽  
Vol 15 (4) ◽  
pp. 343-346
Author(s):  
Dae Hong Shin ◽  
Jae-Wook Yang ◽  
Joong Hyup Kim ◽  
Chong-Kyo Lee ◽  
Won-Keun Chung ◽  
...  
Keyword(s):  
Antiviral Agents ◽  
Cyclic Phosphate ◽  
Cyclic Phosphates ◽  
Derivatives Of

scholarly journals The nonenzymatic template-directed ligation of oligonucleotides

2006 ◽  
Vol 3 (3) ◽  
pp. 243-249 ◽  
Author(s):  
A. V. Lutay ◽  
E. L. Chernolovskaya ◽  
M. A. Zenkova ◽  
V. V. Vlassov
Keyword(s):  
Metal Ion ◽  
Divalent Cations ◽  
Bound Water ◽  
Transesterification Reaction ◽  
Water Molecules ◽  
Pka Values ◽  
Rna Molecules ◽  
High Reaction ◽  
Cyclic Phosphate ◽  
Cyclic Phosphates

Abstract. The nonenzymatic template-directed ligation of oligonucleotides containing 2', 3'-cyclic phosphate was investigated in the presence of divalent cations. Ligation of the oligonucleotides readily occurred in the presence of Mg2+, Mn2+, Co2+, Zn2+, Pb2+. Efficacy of the metal ion catalysts inversely correlated with pKa values of the metal-bound water molecules. The intermolecular transesterification reaction yielded at least 95metal ion. Relatively high reaction yields (up to 15fragmentation to oligonucleotides with 2',3'-cyclic phosphates, followed by reactions of those oligonucleotides could provide a source of new RNA molecules under prebiotic conditions.

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