scholarly journals Transcriptional characterization of the notch signaling pathway in rodent multipotent adult progenitor cells

2007 ◽  
Vol 13 (4) ◽  
pp. 302-310 ◽  
Author(s):  
Melinda Hajdu ◽  
Aernout Luttun ◽  
Beatriz Pelacho ◽  
Terry C Burns ◽  
Lucas Chase ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Progenitor Cells ◽  
Signaling Pathway ◽  
Notch Signaling Pathway ◽  
Multipotent Adult Progenitor Cells

Structural and Functional Characterization of the NHR1 Domain of the Drosophila Neuralized E3 Ligase in the Notch Signaling Pathway

2009 ◽  
Vol 393 (2) ◽  
pp. 478-495 ◽  
Author(s):  
Fahu He ◽  
Kohei Saito ◽  
Naohiro Kobayashi ◽  
Takushi Harada ◽  
Satoru Watanabe ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Signaling Pathway ◽  
Functional Characterization ◽  
E3 Ligase ◽  
Notch Signaling Pathway

scholarly journals Characterization of a new B-ALL cell line with constitutional defect of the Notch signaling pathway

Oncotarget ◽  
2018 ◽  
Vol 9 (26) ◽  
pp. 18341-18350 ◽  
Author(s):  
Paul Takam Kamga ◽  
Giada Dal Collo ◽  
Giulio Bassi ◽  
Martina Midolo ◽  
Massimo Delledonne ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Cell Line ◽  
Signaling Pathway ◽  
Notch Signaling Pathway

scholarly journals Characterization of the Stem Cell Fraction in Pancreatobiliary Carcinomas: The Notch Signaling Pathway as a Potential Therapeutic Target

2018 ◽  
Vol 09 (06) ◽  
pp. 480-502
Author(s):  
Elisabeth Seidel ◽  
Cynthia de Carvalho Fischer ◽  
Christopher Neumann ◽  
Anja Reutzel-Selke ◽  
Andreas Andreou ◽  
...  
Keyword(s):  
Stem Cell ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Therapeutic Target ◽  
Notch Signaling Pathway ◽  
Cell Fraction ◽  
Potential Therapeutic Target

scholarly journals Inhibition of Notch Signaling Promotes the Differentiation of Epicardial Progenitor Cells into Adipocytes

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Bin Liu ◽  
Dinghui Wang ◽  
Tianhua Xiong ◽  
Yajie Liu ◽  
Xiaodong Jing ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Progenitor Cells ◽  
Signaling Pathway ◽  
Adipogenic Differentiation ◽  
Notch Signaling Pathway ◽  
Lineage Tracing ◽  
Induction Medium ◽  
Genetic Lineage ◽  
Ppar Γ

Background. The role of Notch signaling pathway in the differentiation of epicardial progenitor cells (EPCs) into adipocytes is unclear. The objective is to investigate the effects of Notch signaling on the differentiation of EPCs into adipocytes. Methods. Frozen sections of C57BL/6J mouse hearts were used to observe epicardial adipose tissue (EAT), and genetic lineage methods were used to trace EPCs. EPCs were cultured in adipogenic induction medium with Notch ligand jagged-1 or γ-secretase inhibitor DAPT. The adipocyte markers, Notch signaling, and adipogenesis transcription factors were determined. Results. There was EAT located at the atrial–ventricular groove in mouse. By using genetic lineage tracing methods, we found that EPCs were a source of epicardial adipocytes. EPCs had lipid droplet accumulation, and the expression of adipocyte markers FABP-4 and perilipin-1 was upregulated under adipogenic induction. Activating the Notch signaling with jagged-1 attenuated the adipogenic differentiation of EPCs and downregulated the key adipogenesis transcription factor peroxisome proliferator activated receptor-γ (PPAR-γ), while inhibiting the signaling promoted adipogenic differentiation and upregulated PPAR-γ. When blocking PPAR-γ, the role of Notch signaling in promoting adipogenic differentiation was inhibited. Conclusions. EPCs are a source of epicardial adipocytes. Downregulation of the Notch signaling pathway promotes the differentiation of EPCs into adipocytes via PPAR-γ.

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