Immunoreactive trypsin on dried-blood spots as a possible neonatal test for cystic fibrosis

1980 ◽  
Vol 10 (3) ◽  
pp. 511-519 ◽  
Author(s):  
Roberto Dominici ◽  
Fabrizio Monaco ◽  
Silvana Morano ◽  
Italo Antonozzi
Keyword(s):  
Cystic Fibrosis ◽  
Dried Blood Spots ◽  
Immunoreactive Trypsin ◽  
Blood Spots

Neonatal screening for cystic fibrosis, using immunoreactive trypsin assay in dried blood spots

1981 ◽  
Vol 113 (2) ◽  
pp. 111-121 ◽  
Author(s):  
Jeanette R. Crossley ◽  
Patricia A. Smith ◽  
Brian W. Edgar ◽  
Peter D. Gluckman ◽  
Robert B. Elliott
Keyword(s):  
Cystic Fibrosis ◽  
Neonatal Screening ◽  
Dried Blood Spots ◽  
Immunoreactive Trypsin ◽  
Blood Spots

scholarly journals History of Newborn Screening for Cystic Fibrosis—The Early Years

2020 ◽  
Vol 6 (1) ◽  
pp. 8 ◽  
Author(s):  
Georges Travert ◽  
Mary Heeley ◽  
Anthony Heeley
Keyword(s):  
Cystic Fibrosis ◽  
Newborn Screening ◽  
21St Century ◽  
Neonatal Screening ◽  
Dried Blood Spots ◽  
Early Years ◽  
Immunoreactive Trypsin ◽  
Blood Spots ◽  
Screening Strategies ◽  
History Of

This review summarises the trajectory of neonatal screening strategies for the detection of cystic fibrosis (CF) using the measurement of Immunoreactive Trypsin (IRT) in dried blood spots (DBS) from 1979 until the beginning of the 21st century when newborn screening (NBS) programmes started to spread throughout many countries, using IRT measurement combined with a CF genotype analysis of DBS.

An evaluation of an enzyme immunoassay method for immunoreactive trypsin in dried blood spots

1990 ◽  
Vol 23 (3) ◽  
pp. 213-219 ◽  
Author(s):  
Giulio Cabrini ◽  
Fabio Pederzini ◽  
Laura Perobelli ◽  
Gianni Mastella
Keyword(s):  
Enzyme Immunoassay ◽  
Dried Blood Spots ◽  
Immunoreactive Trypsin ◽  
Blood Spots

Use of a dried blood spot in immunoreactive-trypsin assay for detection of cystic fibrosis in infants.

1981 ◽  
Vol 27 (5) ◽  
pp. 678-680 ◽  
Author(s):  
L T Kirby ◽  
D A Applegarth ◽  
A G Davidson ◽  
L T Wong ◽  
D F Hardwick
Keyword(s):  
Cystic Fibrosis ◽  
Premature Infants ◽  
Filter Paper ◽  
Serum Samples ◽  
Immunoreactive Trypsin ◽  
Blood Spots ◽  
Serum Assay ◽  
One Year ◽  
Blood Spot ◽  
Spot Analysis

Abstract We assayed more than 5000 blood spots dried on filter paper and approximately 1000 serum samples for immunoreactive trypsin, with commercial reagents (Behring and Sorin). The assay procedures were modified so that newborn screening is technically feasible. Both kits are satisfactory for serum assay, but the Sorin materials are better adapted for blood spot analysis. Immunoreactive trypsin in blood spots rapidly decreases with specimen age, but is stable in frozen serum. Values for premature infants do not differ significantly from those for full-term babies. Children with cystic fibrosis were readily distinguished from those without, up to at least one year of age.

C-reactive protein measured in dried blood spots from patients with cystic fibrosis

1991 ◽  
Vol 143 (1) ◽  
pp. 69-72 ◽  
Author(s):  
S.M. Cordon ◽  
J.S. Elborn ◽  
E.J. Hiller ◽  
D.J. Shale
Keyword(s):  
Cystic Fibrosis ◽  
Dried Blood Spots ◽  
C Reactive Protein ◽  
Blood Spots ◽  
Reactive Protein
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