Oral administration of probiotic bacteria (E. coli nissle,E. coli O83,Lactobacillus casei) influences the severity of dextran sodium sulfate-induced colitis in BALB/c mice

2006 ◽  
Vol 51 (5) ◽  
pp. 478-484 ◽  
Author(s):  
A. Kokešová ◽  
L. Frolová ◽  
M. Kverka ◽  
D. Sokol ◽  
P. Rossmann ◽  
...  
Keyword(s):  
Oral Administration ◽  
Sodium Sulfate ◽  
Lactobacillus Casei ◽  
Dextran Sodium Sulfate ◽  
Probiotic Bacteria ◽  
E Coli

scholarly journals Slight Disruption in Intestinal Environment by Dextran Sodium Sulfate Reduces Egg Yolk Size Through Disfunction of Ovarian Follicle Growth

2021 ◽  
Vol 11 ◽  
Author(s):  
Takahiro Nii ◽  
Takashi Bungo ◽  
Naoki Isobe ◽  
Yukinori Yoshimura
Keyword(s):  
Gene Expression ◽  
Oral Administration ◽  
Blood Plasma ◽  
Sodium Sulfate ◽  
Egg Production ◽  
Laying Hens ◽  
Ovarian Follicle ◽  
Egg Yolk ◽  
Dextran Sodium Sulfate ◽  
Intestinal Environment

Intestinal environments such as microbiota, mucosal barrier function, and cytokine production affect egg production in laying hens. Dextran sodium sulfate (DSS) is an agent that disrupts the intestinal environment. Previously, we reported that the oral administration of dextran sodium sulfate (DSS: 0.9 g/kg BW) for 5 days caused severe intestinal inflammation in laying hens. However, the DSS concentration in the previous study was much higher to induce a milder disruption of the intestinal environment without heavy symptoms. Thus, the goal of this study was to determine the effects of a lower dose of DSS on the intestinal environment and egg production in laying hens. White Leghorn laying hens (330-day old) were oral administered with or without 0.225 g DSS/kg BW for 28 days (DSS and control group: n = 7 and 8, respectively). Weekly we collected all laid eggs and blood plasma samples. Intestinal tissues, liver, ovarian follicles, and the anterior pituitary gland were collected 1 day after the final treatment. Lower concentrations of orally administered DSS caused (1) a decrease in the ratio of villus height/crypt depth, occludin gene expressions in large intestine and cecal microbiota diversity, (2) a decrease in egg yolk weight, (3) an increase in VLDLy in blood plasma, (4), and enhanced the egg yolk precursor accumulation in the gene expression pattern in the follicular granulosa layer, (5) an increase in FSH and IL-1β gene expression in the pituitary gland, and (6) an increase in concentration of plasma lipopolysaccharide binding protein. These results suggested that the administration of the lower concentration of DSS caused a slight disruption in the intestinal environment. This disruption included poor intestinal morphology and decreased cecal microbiome diversity. The change in the intestinal environment decreases egg yolk size without decreasing the VLDLy supply from the liver. The decrease in egg yolk size is likely to be caused by the dysfunction of egg-yolk precursor uptake in ovarian follicles. In conclusion, the oral administration of a lower dose of DSS is an useful method to cause slight disruptions of intestinal environment, and the intestinal condition decreases egg yolk size through disfunction of ovarian follicle.

Lactobacillus casei protects dextran sodium sulfate- or rapamycin-induced colonic inflammation in the mouse

2019 ◽  
Vol 59 (4) ◽  
pp. 1443-1451 ◽  
Author(s):  
Yong Zhang ◽  
Qiangchuan Hou ◽  
Chen Ma ◽  
Jie Zhao ◽  
Haiyan Xu ◽  
...  
Keyword(s):  
Sodium Sulfate ◽  
Lactobacillus Casei ◽  
Dextran Sodium Sulfate ◽  
Colonic Inflammation

scholarly journals Dietary cranberry suppressed colonic inflammation and alleviated gut microbiota dysbiosis in dextran sodium sulfate-treated mice

2019 ◽  
Vol 10 (10) ◽  
pp. 6331-6341 ◽  
Author(s):  
Xiaokun Cai ◽  
Yanhui Han ◽  
Min Gu ◽  
Mingyue Song ◽  
Xian Wu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Oral Administration ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Colonic Inflammation ◽  
Freeze Dried ◽  
Gut Microbiota Dysbiosis

Oral administration of freeze-dried whole cranberry powder via diet inhibited colitis in dextran sodium sulfate-treated mice, which was associated with modification of gut microbiota.

Oral Administration of Hen Egg White Ovotransferrin Attenuates the Development of Colitis Induced by Dextran Sodium Sulfate in Mice

2015 ◽  
Vol 63 (5) ◽  
pp. 1532-1539 ◽  
Author(s):  
Yutaro Kobayashi ◽  
Prithy Rupa ◽  
Jennifer Kovacs-Nolan ◽  
Patricia V. Turner ◽  
Toshiro Matsui ◽  
...  
Keyword(s):  
Oral Administration ◽  
Sodium Sulfate ◽  
Egg White ◽  
Dextran Sodium Sulfate ◽  
Hen Egg White ◽  
Hen Egg

scholarly journals Dextran Sodium Sulfate-Induced Inflammation Alters the Expression of Proteins by Intestinal Escherichia coli Strains in a Gnotobiotic Mouse Model

2011 ◽  
Vol 78 (5) ◽  
pp. 1513-1522 ◽  
Author(s):  
Sara Schumann ◽  
Carl Alpert ◽  
Wolfram Engst ◽  
Gunnar Loh ◽  
Michael Blaut
Keyword(s):  
Escherichia Coli ◽  
Sodium Sulfate ◽  
Intestinal Inflammation ◽  
Dextran Sodium Sulfate ◽  
Differentially Expressed ◽  
Differentially Expressed Proteins ◽  
Uncharacterized Protein ◽  
Fermentation Products ◽  
Content Type ◽  
E Coli

ABSTRACTTo identifyEscherichia coliproteins involved in adaptation to intestinal inflammation, mice were monoassociated with the colitogenicE. colistrain UNC or with the probioticE. colistrain Nissle. Intestinal inflammation was induced by treating the mice with 3.5% dextran sodium sulfate (DSS). Differentially expressed proteins inE. colistrains collected from cecal contents were identified by 2-dimensional difference gel electrophoresis. In both strains, acute inflammation led to the downregulation of pathways involved in carbohydrate breakdown and energy generation. Accordingly, DSS-treated mice had lower concentrations of bacterial fermentation products in their cecal contents than control mice. Differentially expressed proteins also included the Fe-S cluster repair protein NfuA, the tryptophanase TnaA, and the uncharacterized protein YggE. NfuA expression was 3-fold higher inE. colistrains from DSS-treated than from control mice. Reporter experiments confirmed the induction ofnfuAin response to iron deprivation, mimicking Fe-S cluster destruction by inflammation. YggE expression, which has been reported to reduce the intracellular level of reactive oxygen species, was 4- to 8-fold higher inE. coliNissle than inE. coliUNC. This was confirmed byin vitroreporter gene assays indicating that Nissle is better equipped to cope with oxidative stress than UNC. Nissle isolated from DSS-treated and control mice had TnaA levels 4- to 7-fold-higher than those of UNC. Levels of indole resulting from the TnaA reaction were higher in control animals associated withE. coliNissle. Because of its anti-inflammatory effect, indole is hypothesized to be involved in the extension of the remission phase in ulcerative colitis described forE. coliNissle.

scholarly journals Oral Administration of Lactobacillus casei and Bifidobacterium bifidum Improves Glucagon like Peptide-1(GLP-1) and Glucose-Dependent Insulinotropic Polypeptide (GIP) Level in Streptozotocin Induced Diabetic Rats

2021 ◽  
Vol 9 (2) ◽  
pp. 431-440
Author(s):  
Sumiran Srivastava ◽  
Prof. Rambir Singh
Keyword(s):  
Body Weight ◽  
Single Dose ◽  
Oral Administration ◽  
Lactobacillus Casei ◽  
Tolerance Test ◽  
Diabetic Rats ◽  
Bifidobacterium Bifidum ◽  
Probiotic Bacteria ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

The gut microbiome plays significant role in the function and integrity of the gastrointestinal tract. They also maintain immune homeostasis and host energy metabolism. The metabolic products of these intestinal microbes can alter carbohydrate metabolism, nutrient absorption and reduce appetite to promote healthy lifestyle. Intestinal disbiosis observed in metabolic disorders like obesity and diabetes. Restoration of dysbiosed gut microbiome through oral administration of probiotics that may have profound health effect in diabetes. In case of diabetes, reports postulated impaired level of incretin, therefore we explored the effect of oral administration of probiotic bacteria Lactobacillus casei NCDC 017 (LC017) and Bifidobacterium bifidum NCDC 231 (BB231) alone and in combination on secretion of incretin hormones such as glucagon like peptide-1 and glucose dependent insulinotropic polypeptide. Thirty six male Wistar rats were randomly divided into six groups and diabetes was induced by single dose of streptozotocin (50 mg/kg body weight) in experimental rats intraperitonially except a group of healthy rats. The diabetic rats were daily administered orally with single dose (~107cfu/ml) of LC017 and BB231 alone and in combination for 28 days. Also, one group of diabetic rats was treated with an anti-diabetic drug, acarbose (10mg/kg body weight) and used a standard control. The change in body weight, sucrose tolerance test, GLP-1, GIP level in serum and GLP-1 level in different part of intestine were observed. The results have shown reduction in body weight in diabetic rats as compared to non-diabetic rats but improved after treatment of probiotic bacteria. Administration of LC017 and BB231 significantly improved GLP-1 and GIP level which were initially impaired in diabetic rats and their combination significantly decreased glucose level in sucrose tolerance test. This study indicated that LC017 and BB231 have significant hypoglycaemic potential in diabetic rats by increasing GLP-1 and GIP level. These findings offered a base for the use of LC017 and BB231 for improvement and treatment of diabetes.

Preventive efficacy of butyrate enemas and oral administration of Clostridium butyricum M588 in dextran sodium sulfate-induced colitis in rats

2000 ◽  
Vol 35 (5) ◽  
pp. 341-346 ◽  
Author(s):  
Toshihiko Okamoto ◽  
Masaya Sasaki ◽  
Tomoyuki Tsujikawa ◽  
Yoshihide Fujiyama ◽  
Tadao Bamba ◽  
...  
Keyword(s):  
Oral Administration ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Clostridium Butyricum ◽  
Preventive Efficacy

Effect of Oral Administration of 3,3′-Diindolylmethane on Dextran Sodium Sulfate-Induced Acute Colitis in Mice

2016 ◽  
Vol 64 (41) ◽  
pp. 7702-7709 ◽  
Author(s):  
Eun-Joo Jeon ◽  
Munkhtugs Davaatseren ◽  
Jin-Taek Hwang ◽  
Jae Ho Park ◽  
Haeng Jeon Hur ◽  
...  
Keyword(s):  
Oral Administration ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Acute Colitis
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