Effect of scarlet fever toxin on the phagocytic activity of the reticuloendothelial system

1979 ◽  
Vol 24 (5) ◽  
pp. 415-427 ◽  
Author(s):  
V. Hříbalová ◽  
Z. Both ◽  
F. Zahradník
Keyword(s):  
Phagocytic Activity ◽  
Scarlet Fever ◽  
Reticuloendothelial System ◽  
Scarlet Fever Toxin

Reticuloendothelial depression with superior mesenteric artery occlusion

1963 ◽  
Vol 204 (5) ◽  
pp. 899-902 ◽  
Author(s):  
Benjamin Blattberg ◽  
Matthew N. Levy
Keyword(s):  
Superior Mesenteric Artery ◽  
Phagocytic Activity ◽  
Mesenteric Artery ◽  
Intestinal Ischemia ◽  
Reticuloendothelial System ◽  
Venous Flow ◽  
Hepatic Ischemia ◽  
Flow Measurements ◽  
Gram Negative ◽  
Arterial Blood

Normotensive, splenectomized dogs were subjected to intestinal ischemia by occlusion of the superior mesenteric artery (SMA) for periods of 15–90 min. Autoperfusion of the liver with arterial blood at normal flow rates was maintained in order to prevent hepatic ischemia during the period of SMA occlusion. The phagocytic activity of the hepatic reticuloendothelial system was assessed by measuring the clearance of carbon particles. Intestinal ischemia for 30 min led to a significant ( P < 0.01) depression of carbon clearance. However, increasing the duration of ischemia to as long as 90 min did not produce a significantly greater depression of the clearance rate. Portal venous flow measurements, made just prior to the time of carbon injections, demonstrated that reduced phagocytic activity could not be attributed to reduced hepatic blood flow. Since ischemia of the hepatic RES was prevented during the period of SMA occlusion, it is probable that a humoral reticuloendothelial substance was produced by the ischemic intestine, as previously demonstrated in dogs subjected to hemorrhagic hypotension. In dogs treated with antibiotics to eliminate the gram-negative fecal flora, occlusion of the SMA for 1 hr caused depression of granulopectic activity. This suggests that gram-negative bacterial products are not required for the formation of the reticuloendothelial depressing substance.

The pyrogenic effect of scarlet fever toxin

1966 ◽  
Vol 11 (2) ◽  
pp. 112-122 ◽  
Author(s):  
V. Schuh ◽  
Věra Hříbalová
Keyword(s):  
Scarlet Fever ◽  
Scarlet Fever Toxin

scholarly journals The Titration of Scarlet Fever Toxin

1930 ◽  
Vol 29 (4) ◽  
pp. 357-361 ◽  
Keyword(s):  
Scarlet Fever ◽  
Early Stage ◽  
Final Choice ◽  
Careful Choice ◽  
Clinical Observations ◽  
Scarlet Fever Toxin

The final choice of a suitable dilution of a given toxin will be made, partly from the difficult comparison with other known toxins, but mainly from the results of clinical observations in patients in the early stage of scarlet fever and in convalescents.It is difficult to titrate scarlet fever toxin with accuracy. It will probably be found that by careful choice of subject and by several readings of the reactions at different intervals after the injection, one can differentiate between toxins of values x and 2x.

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