Phagocytic activity of the blood leukocytes and cells of the reticuloendothelial system and antibody production in mice kept at a lowered atmospheric pressure

1966 ◽  
Vol 62 (5) ◽  
pp. 1282-1284
Author(s):  
G. N. Durnova ◽  
A. S. Kaplanskii ◽  
N. A. Roshchina
1963 ◽  
Vol 204 (5) ◽  
pp. 899-902 ◽  
Author(s):  
Benjamin Blattberg ◽  
Matthew N. Levy

Normotensive, splenectomized dogs were subjected to intestinal ischemia by occlusion of the superior mesenteric artery (SMA) for periods of 15–90 min. Autoperfusion of the liver with arterial blood at normal flow rates was maintained in order to prevent hepatic ischemia during the period of SMA occlusion. The phagocytic activity of the hepatic reticuloendothelial system was assessed by measuring the clearance of carbon particles. Intestinal ischemia for 30 min led to a significant ( P < 0.01) depression of carbon clearance. However, increasing the duration of ischemia to as long as 90 min did not produce a significantly greater depression of the clearance rate. Portal venous flow measurements, made just prior to the time of carbon injections, demonstrated that reduced phagocytic activity could not be attributed to reduced hepatic blood flow. Since ischemia of the hepatic RES was prevented during the period of SMA occlusion, it is probable that a humoral reticuloendothelial substance was produced by the ischemic intestine, as previously demonstrated in dogs subjected to hemorrhagic hypotension. In dogs treated with antibiotics to eliminate the gram-negative fecal flora, occlusion of the SMA for 1 hr caused depression of granulopectic activity. This suggests that gram-negative bacterial products are not required for the formation of the reticuloendothelial depressing substance.


1991 ◽  
Vol 12 (2) ◽  
pp. 97-100 ◽  
Author(s):  
M. Trop ◽  
E. J. Schiffrin ◽  
W. Jung ◽  
H. P. Ehrlich ◽  
E. A. Carter

2011 ◽  
Vol 3 (3) ◽  
pp. 619-630 ◽  
Author(s):  
S. P. Pattanayak ◽  
P. M. Mazumder

In the present study, an attempt was made to screen immunomodulatory activity of the hydroalcoholic extract (HEDF) of Dendrophthoe falcata (L.f.) Ettingsh (Loranthaceae), an Indian Ayurvedic plant, on different arms of the immune system. HEDF was evaluated for immunological function by studying delayed type hypersensitivity (DTH) to sheep RBCs, nitric oxide (NO) release from murine peritoneal macrophages, phagocytic activity of polymorphonuclear (PMN) cells in vitro and reticuloendothelial system in vivo, plaque forming cell response of splenic lymphocytes to sheep erythrocytes, haemagglutination antibody titer and neutrophil adhesion test. Significant increase in NO production by mouse peritoneal macrophages was detected in culture supernatants indicated increased phagocytic activity of macrophages. After post oral administration of HEDF in three doses of 250, 475 and 950 mg/kg body weight, a significant increase in phagocytic activity of PMN cells/reticuloendothelial system, stimulation of neutrophil function and splenic antibody secreting cells, were also noticed. Stimulation of humoral immune response was further observed with elevation in haemagglutination antibody titer. Heightened DTH reaction suggested convincing evidence for activation of cellular immune system. Present study thus confirms the immunomodulatory activity of the hydroalcoholic extract of D. falcata and the immunomodulatory responses were found to be dose dependent manner.Keywords: Dendrophthoe falcata; Antibody titer; Neutrophil adhesion; Phagocytic activity.© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi:10.3329/jsr.v3i3.7655               J. Sci. Res. 3 (3), 629-640 (2011)


1984 ◽  
Vol 35 (6) ◽  
pp. 605-615 ◽  
Author(s):  
M. Holub ◽  
L. Fornůsek ◽  
V. Větvička ◽  
J. Chalupná

Hepatology ◽  
1984 ◽  
Vol 4 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Antoni Rimola ◽  
Ramón Soto ◽  
Felipe Bory ◽  
Vicente Arroyo ◽  
Carlos Piera ◽  
...  

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