Tryptophan hydroxylase and catechol-O-methyltransferase gene polymorphisms: relationships to monoamine metabolite concentrations in CSF of healthy volunteers

1997 ◽  
Vol 247 (6) ◽  
pp. 297-302 ◽  
Author(s):  
Erik G. Jönsson ◽  
David Goldman ◽  
Gillian Spurlock ◽  
J. Petter Gustavsson ◽  
David A. Nielsen ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Gene Polymorphisms ◽  
Tryptophan Hydroxylase ◽  
Metabolite Concentrations ◽  
Methyltransferase Gene ◽  
Monoamine Metabolite

scholarly journals Monoamine related functional gene variants and relationships to monoamine metabolite concentrations in CSF of healthy volunteers

2004 ◽  
Vol 4 (1) ◽  
Author(s):  
Erik G Jönsson ◽  
Jessica Bah ◽  
Jonas Melke ◽  
Rami Abou Jamra ◽  
Johannes Schumacher ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Functional Gene ◽  
Gene Variants ◽  
Metabolite Concentrations ◽  
Monoamine Metabolite

Modulation of Plasma Fibrinogen Levels by Ticlopidine in Healthy Volunteers and Patients with Stable Angina Pectoris

1996 ◽  
Vol 76 (02) ◽  
pp. 166-170 ◽  
Author(s):  
Moniek P M de Maat ◽  
Alf E R Arnold ◽  
Stef van Buuren ◽  
J H Paul Wilson ◽  
Cornells Kluft
Keyword(s):  
Angina Pectoris ◽  
Healthy Volunteers ◽  
Acute Phase ◽  
Stable Angina ◽  
Gene Polymorphisms ◽  
Acute Phase Reaction ◽  
Plasma Fibrinogen ◽  
Phase Reaction ◽  
Stable Angina Pectoris ◽  
Lowering Effect

SummaryElevated plasma fibrinogen levels are associated with an increased risk for cardiac events. Ticlopidine is a drug that inhibits the ADP-induced aggregation of blood platelets and it also has been described that ticlopidine can decrease the plasma fibrinogen level in patients with vascular diseases. The mechanism of this decrease has not yet been elucidated and therefore mechanisms that are known to affect fibrinogen levels were studied, viz. the acute phase reaction, total fibrin plus fibrinogen degradation (TDP) levels and the polymorphisms of the fibrinogen β-gene.The fibrinogen lowering effect of ticlopidine was studied in 26 healthy volunteers, selected on genotype of the BclI polymorphism of the fibrinogen β-gene, and in 26 patients with stable angina pectoris in a double blind, randomized cross-over study. Functional plasma fibrinogen levels were measured with the Clauss assay. Fibrinogen antigen, C-reactive protein (CRP) and TDP levels were measured using an enzyme immuno assay (EIA).In the healthy volunteers the functional fibrinogen levels had decreased by 0.20 g/l (9%, p = 0.005 using the paired Student t-test) after 4 weeks of 250 mg bid ticlopidine administration, whereas fibrinogen antigen, CRP and TDP levels were not significantly changed. In the stable angina pectoris patients the pre-treatment fibrinogen, CRP and TDP levels were significantly higher than in the volunteer group. After four weeks 250 mg bid ticlopidine administration the functional fibrinogen levels had decreased by 0.38 g/l (11%, p < 0.005), whereas the fibrinogen antigen, CRP and TDP levels were not significantly changed. The levels of functional and antigen fibrinogen, CRP and TDP did not change significantly during the placebo period in the volunteers or the patients. Neither in the volunteers nor in the patients was the effect of ticlopidine on the fibrinogen levels associated with the fibrinogen β-gene polymorphisms.Therefore, the fibrinogen lowering effect of ticlopidine is likely to be a modulation of the functionality of the molecule and unlikely to be modulated by the acute phase reaction, TDP-levels or the fibrinogen β-gene polymorphisms.

Effect of Chronic Nicotine Administration on Monoamine and Monoamine Metabolite Concentrations in Rat Brain

1987 ◽  
Vol 10 (4) ◽  
pp. 376-383 ◽  
Author(s):  
Darrell G. Kirch ◽  
Greg A. Gerhardt ◽  
Richard C. Shelton ◽  
Robert Freedman ◽  
Richard J. Wyatt
Keyword(s):  
Rat Brain ◽  
Chronic Nicotine ◽  
Nicotine Administration ◽  
Metabolite Concentrations ◽  
Monoamine Metabolite

scholarly journals Involvement of Human Histamine N-Methyltransferase Gene Polymorphisms in Susceptibility to Atopic Dermatitis in Korean Children

2012 ◽  
Vol 4 (1) ◽  
pp. 31 ◽  
Author(s):  
Hee Seon Lee ◽  
Seung-Hyun Kim ◽  
Kyung Won Kim ◽  
Ji Young Baek ◽  
Hae-Sim Park ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Gene Polymorphisms ◽  
Korean Children ◽  
Methyltransferase Gene ◽  
Human Histamine

scholarly journals No Clinical Impact of CYP3A5 Gene Polymorphisms on the Pharmacokinetics and/or Efficacy of Maraviroc in Healthy Volunteers and HIV‐1–Infected Subjects

2018 ◽  
Vol 59 (1) ◽  
pp. 139-152
Author(s):  
Manoli Vourvahis ◽  
Lynn McFadyen ◽  
Sunil Nepal ◽  
Srinivas Rao Valluri ◽  
Annie Fang ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Gene Polymorphisms ◽  
Clinical Impact ◽  
Cyp3a5 Gene ◽  
Hiv 1
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