scholarly journals No Clinical Impact of CYP3A5 Gene Polymorphisms on the Pharmacokinetics and/or Efficacy of Maraviroc in Healthy Volunteers and HIV‐1–Infected Subjects

2018 ◽  
Vol 59 (1) ◽  
pp. 139-152
Author(s):  
Manoli Vourvahis ◽  
Lynn McFadyen ◽  
Sunil Nepal ◽  
Srinivas Rao Valluri ◽  
Annie Fang ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Gene Polymorphisms ◽  
Clinical Impact ◽  
Cyp3a5 Gene ◽  
Hiv 1

Modulation of Plasma Fibrinogen Levels by Ticlopidine in Healthy Volunteers and Patients with Stable Angina Pectoris

1996 ◽  
Vol 76 (02) ◽  
pp. 166-170 ◽  
Author(s):  
Moniek P M de Maat ◽  
Alf E R Arnold ◽  
Stef van Buuren ◽  
J H Paul Wilson ◽  
Cornells Kluft
Keyword(s):  
Angina Pectoris ◽  
Healthy Volunteers ◽  
Acute Phase ◽  
Stable Angina ◽  
Gene Polymorphisms ◽  
Acute Phase Reaction ◽  
Plasma Fibrinogen ◽  
Phase Reaction ◽  
Stable Angina Pectoris ◽  
Lowering Effect

SummaryElevated plasma fibrinogen levels are associated with an increased risk for cardiac events. Ticlopidine is a drug that inhibits the ADP-induced aggregation of blood platelets and it also has been described that ticlopidine can decrease the plasma fibrinogen level in patients with vascular diseases. The mechanism of this decrease has not yet been elucidated and therefore mechanisms that are known to affect fibrinogen levels were studied, viz. the acute phase reaction, total fibrin plus fibrinogen degradation (TDP) levels and the polymorphisms of the fibrinogen β-gene.The fibrinogen lowering effect of ticlopidine was studied in 26 healthy volunteers, selected on genotype of the BclI polymorphism of the fibrinogen β-gene, and in 26 patients with stable angina pectoris in a double blind, randomized cross-over study. Functional plasma fibrinogen levels were measured with the Clauss assay. Fibrinogen antigen, C-reactive protein (CRP) and TDP levels were measured using an enzyme immuno assay (EIA).In the healthy volunteers the functional fibrinogen levels had decreased by 0.20 g/l (9%, p = 0.005 using the paired Student t-test) after 4 weeks of 250 mg bid ticlopidine administration, whereas fibrinogen antigen, CRP and TDP levels were not significantly changed. In the stable angina pectoris patients the pre-treatment fibrinogen, CRP and TDP levels were significantly higher than in the volunteer group. After four weeks 250 mg bid ticlopidine administration the functional fibrinogen levels had decreased by 0.38 g/l (11%, p < 0.005), whereas the fibrinogen antigen, CRP and TDP levels were not significantly changed. The levels of functional and antigen fibrinogen, CRP and TDP did not change significantly during the placebo period in the volunteers or the patients. Neither in the volunteers nor in the patients was the effect of ticlopidine on the fibrinogen levels associated with the fibrinogen β-gene polymorphisms.Therefore, the fibrinogen lowering effect of ticlopidine is likely to be a modulation of the functionality of the molecule and unlikely to be modulated by the acute phase reaction, TDP-levels or the fibrinogen β-gene polymorphisms.

scholarly journals Hyperbaric hyperoxia exposure in suppressing human immunodeficiencyvirus replication: An experimental in vitro in peripheral mononuclear blood cells culture

2020 ◽  
Author(s):  
Retno Budiarti ◽  
Siti Qamariyah Khairunisa ◽  
Nasronudin ◽  
Kuntaman ◽  
Guritno
Keyword(s):  
Hiv Infection ◽  
Healthy Volunteers ◽  
Hyperbaric Oxygen ◽  
Experimental Unit ◽  
Control Group ◽  
P24 Antigen ◽  
Hyperbaric Exposure ◽  
Interferon Α2 ◽  
Hiv 1

Cellular immune has an important role in response HIV infection, which is attack the infected cells to activate signaling molecule. Hyperbaric Oxygen (HBO) worked as complementary treatment for HIV infection. The production of ROS and RNS molecules during hyperbaric exposure can affect gene expression which contributes to cellular adaptative response. This study was conducted to explore the mechanisms of cellular adaptive response to HIV infection during hyperbaric exposure. This study was carried on in vitro using healthy volunteers’ PBMCs (Peripheral Blood Mononuclear Cells) cultures infected with HIV-1. The study was conducted as a post- test only group design. The experimental unit was PBMC from venous blood of healthy volunteers which were cultured in vitro and infected by co-culturing with HIV-1 in MT4 cell line. The experimental unit consist of treatment and control group. Each group examined the expression of transcription factor NFκB, Interferon α, reverse transcriptase inhibitors (p21), and the amount of HIV-1 p24 antigen. There were increasingly significant differences in the expression of the trancription factor of NFκB, p21, and HIV-1 p24 antigen,as well as mRNA transcription of interferon α2 between treatment and controlgroup. By decreasing p24 antigen showed that HBO exposure was able to suppress HIV-1 replication. The exposure to hyperbaric oxygen at the pressure of 2.4 ATAand 98% oxygen wasable to produce ROS and RNS molecules, which play a role in cellular adaptive responses through increasing the expression of nfĸb, p21 and mRNA of interferon α2 plays a role in inhibition mechanism of HIV-1 replication in cells.

scholarly journals Correction: Safety and vaccine-induced HIV-1 immune responses in healthy volunteers following a late MVA-B boost 4 years after the last immunization

PLoS ONE ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. e0195915 ◽  
Author(s):  
Alberto C. Guardo ◽  
Carmen Elena Gómez ◽  
Vicens Díaz-Brito ◽  
Judit Pich ◽  
Joan Albert Arnaiz ◽  
...  
Keyword(s):  
Immune Responses ◽  
Healthy Volunteers ◽  
Hiv 1

scholarly journals CYP4F2 and CYP3A5 gene polymorphisms and lung cancer in Chinese Han population

2020 ◽  
Vol 20 (3) ◽  
pp. 461-468
Author(s):  
Ruiqing He ◽  
Meng Li ◽  
Anqi Li ◽  
Wenhui Dang ◽  
Tian Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Gene Polymorphisms ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Cyp3a5 Gene

DEFB1 gene polymorphisms and increased risk of HIV-1 infection in Brazilian children

AIDS ◽  
2006 ◽  
Vol 20 (12) ◽  
pp. 1673-1675 ◽  
Author(s):  
Michele Milanese ◽  
Ludovica Segat ◽  
Alessandra Pontillo ◽  
Luiz Claudio Arraes ◽  
José Luiz de Lima Filho ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Increased Risk ◽  
Hiv 1 ◽  
Brazilian Children
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