scholarly journals A comparative study of reactive oxygen species (ROS) related parameters in rat tissues

2006 ◽  
Vol 21 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Samir P. Patel ◽  
Surendra S. Katyare
Keyword(s):  
Reactive Oxygen Species ◽  
Comparative Study ◽  
Reactive Oxygen ◽  
Rat Tissues ◽  
Oxygen Species

Reactive Oxygen Species and DNA Oxidation in Fetal Rat Tissues

1998 ◽  
Vol 25 (1) ◽  
pp. 95-103 ◽  
Author(s):  
Alan G Fantel ◽  
Bruce Mackler ◽  
Louis D Stamps ◽  
Tung T Tran ◽  
Richard E Person
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Dna Oxidation ◽  
Rat Tissues ◽  
Oxygen Species ◽  
Fetal Rat

scholarly journals The Relationship between Mitochondrial Reactive Oxygen Species Production and Mitochondrial Energetics in Rat Tissues with Different Contents of Reduced Coenzyme Q

Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 533
Author(s):  
Karolina Dominiak ◽  
Wieslawa Jarmuszkiewicz
Keyword(s):  
Reactive Oxygen Species ◽  
Coenzyme Q ◽  
Reactive Oxygen ◽  
Tissue Level ◽  
Rat Tissues ◽  
Ros Production ◽  
Oxygen Species ◽  
Mitochondrial Ros ◽  
Species Production ◽  
The Relationship

We investigated the relationship between mitochondrial production of reactive oxygen species (ROS) and mitochondrial energetics in various rat tissues with different contents of the reduced coenzyme Q (Q) pool (Q9 + Q10). Our results indicate that similar to the tissue level, mitochondrial H2O2 release under nonphosphorylating conditions was strongly dependent on the amount of the reduced Q pool. Namely, in brain and lung mitochondria, less H2O2 release corresponded to a less reduced Q pool, while in liver and heart mitochondria, higher H2O2 release corresponded to a more reduced Q pool. We can conclude that the differences observed in rat tissues in the size of the reduced Q pool reflect different levels of ROS production and hence may reflect different demands for reduced Q as an antioxidant. Moreover, differences in mitochondrial H2O2 release were observed in different types of rat mitochondria during the oxidation of succinate (complex II substrate), malate plus glutamate (complex I substrate), and their mixture under phosphorylating and nonphosphorylating conditions. Our results indicate the existence of a tissue-specific maximum respiratory chain capacity in ROS production, possibly related to the membrane potential-mediated control of oxidative phosphorylation. We propose the use of a new parameter for the study of isolated mitochondria, RCRROS, the ratio between the formation of mitochondrial ROS under nonphosphorylating and phosphorylating conditions, which represents the maximum factorial increase in mitochondrial ROS formation that can be achieved after all ADP is phosphorylated.

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